$Quantitative Detection of the M204V Hepatitis B Virus Minor Variants by Amplification Refractory Mutation System Real-Time PCR Combined with Molecular Beacon Technology$

Quantitative Detection of the M204V Hepatitis B Virus Minor Variants by Amplification Refractory Mutation System Real-Time PCR Combined with Molecular Beacon Technology

Mutations in the highly conserved tyrosine-methionine-aspartate-aspartate (YMDD) motif are frequently associated with resistance to antivirals and represent a major concern in the treatment of hepatitis B virus (HBV) infection. Conventional methods fail to detect minority populations of drug-resista...

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Veröffentlicht in:	Journal of Clinical Microbiology 2009-08, Vol.47 (8), p.2544-2550
Hauptverfasser:	Ntziora, F, Paraskevis, D, Haida, C, Magiorkinis, E, Manesis, E, Papatheodoridis, G, Manolakopoulos, S, Beloukas, A, Chryssoy, S, Magiorkinis, G, Sypsa, V, Hatzakis, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug Resistance, Viral Fundamental and applied biological sciences. Psychology Genotype Hepatitis B - drug therapy Hepatitis B - virology Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Humans Microbial Sensitivity Tests - methods Microbiology Miscellaneous Mutation, Missense Polymerase Chain Reaction - methods Sensitivity and Specificity Virology
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