Incorporation and release of vancomycin from Poly(D, L-lactide-co-glycolide) microspheres

Abstract Spherical monolithic microspheres, with a honeycomb-like internal architecture, composed of PLCG 50:50 and PLCG 75:25 and containing a range of vancomycin loadings, have been fabricated using a W/O emulsification with solvent evaporation technique. Microspheres were generated in high yield...

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Veröffentlicht in:	Journal of microencapsulation 1998, Vol.15 (1), p.31-44
Hauptverfasser:	Atkins, T. W., Peacock, S. J., Yates, D. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biocompatible Materials - administration & dosage Biocompatible Materials - chemistry Biocompatible Materials - pharmacokinetics Biological and medical sciences Buffers Cattle Chemistry, Pharmaceutical General pharmacology Hydrogen-Ion Concentration Lactic Acid - administration & dosage Lactic Acid - chemistry Lactic Acid - pharmacokinetics Medical sciences Microspheres newborn calf serum Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly(D. L-lactide-co-glycolide) Polyglycolic Acid - administration & dosage Polyglycolic Acid - chemistry Polyglycolic Acid - pharmacokinetics Polymers - administration & dosage Polymers - chemistry Polymers - pharmacokinetics Vancomycin - administration & dosage Vancomycin - chemistry Vancomycin - pharmacokinetics vancomycin incorporation and release W/O emulsification
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