Incorporation and release of vancomycin from Poly(D, L-lactide-co-glycolide) microspheres
Abstract Spherical monolithic microspheres, with a honeycomb-like internal architecture, composed of PLCG 50:50 and PLCG 75:25 and containing a range of vancomycin loadings, have been fabricated using a W/O emulsification with solvent evaporation technique. Microspheres were generated in high yield...
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| Veröffentlicht in: | Journal of microencapsulation 1998, Vol.15 (1), p.31-44 |
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| creator | Atkins, T. W. Peacock, S. J. Yates, D. J. |
| description | Abstract
Spherical monolithic microspheres, with a honeycomb-like internal architecture, composed of PLCG 50:50 and PLCG 75:25 and containing a range of vancomycin loadings, have been fabricated using a W/O emulsification with solvent evaporation technique. Microspheres were generated in high yield (80wgt%) and vancornycin incorporation, confirmed using the displacement of DSC thermograms, had no significant effect on microsphere size distribution (5-50 μm). The vancomycin encapsulation efficiency was high (>64%) and release profiles were characterized by a substantial initial burst release and a subsequent low-level sustained release extending up to 30 days depending upon the fabrication polymer, % vancornycin loading and incubation medium used. In both Hank's buffer and newborn calf serum the mean total cumulative release of vancomycin from microspheres increased significantly with theoretical percentage loading. |
| doi_str_mv | 10.3109/02652049809006833 |
| format | Article |
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Spherical monolithic microspheres, with a honeycomb-like internal architecture, composed of PLCG 50:50 and PLCG 75:25 and containing a range of vancomycin loadings, have been fabricated using a W/O emulsification with solvent evaporation technique. Microspheres were generated in high yield (80wgt%) and vancornycin incorporation, confirmed using the displacement of DSC thermograms, had no significant effect on microsphere size distribution (5-50 μm). The vancomycin encapsulation efficiency was high (>64%) and release profiles were characterized by a substantial initial burst release and a subsequent low-level sustained release extending up to 30 days depending upon the fabrication polymer, % vancornycin loading and incubation medium used. In both Hank's buffer and newborn calf serum the mean total cumulative release of vancomycin from microspheres increased significantly with theoretical percentage loading.</description><identifier>ISSN: 0265-2048</identifier><identifier>EISSN: 1464-5246</identifier><identifier>DOI: 10.3109/02652049809006833</identifier><identifier>PMID: 9463805</identifier><identifier>CODEN: JOMIEF</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject><![CDATA[Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacokinetics ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biocompatible Materials - administration & dosage ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacokinetics ; Biological and medical sciences ; Buffers ; Cattle ; Chemistry, Pharmaceutical ; General pharmacology ; Hydrogen-Ion Concentration ; Lactic Acid - administration & dosage ; Lactic Acid - chemistry ; Lactic Acid - pharmacokinetics ; Medical sciences ; Microspheres ; newborn calf serum ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; poly(D. L-lactide-co-glycolide) ; Polyglycolic Acid - administration & dosage ; Polyglycolic Acid - chemistry ; Polyglycolic Acid - pharmacokinetics ; Polymers - administration & dosage ; Polymers - chemistry ; Polymers - pharmacokinetics ; Vancomycin - administration & dosage ; Vancomycin - chemistry ; Vancomycin - pharmacokinetics ; vancomycin incorporation and release ; W/O emulsification]]></subject><ispartof>Journal of microencapsulation, 1998, Vol.15 (1), p.31-44</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-39a47176c192e950e013e830c86579e8702387438435b4ee44ebb0792ba31a1b3</citedby><cites>FETCH-LOGICAL-c430t-39a47176c192e950e013e830c86579e8702387438435b4ee44ebb0792ba31a1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02652049809006833$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02652049809006833$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2169499$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9463805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atkins, T. W.</creatorcontrib><creatorcontrib>Peacock, S. J.</creatorcontrib><creatorcontrib>Yates, D. J.</creatorcontrib><title>Incorporation and release of vancomycin from Poly(D, L-lactide-co-glycolide) microspheres</title><title>Journal of microencapsulation</title><addtitle>J Microencapsul</addtitle><description>Abstract
Spherical monolithic microspheres, with a honeycomb-like internal architecture, composed of PLCG 50:50 and PLCG 75:25 and containing a range of vancomycin loadings, have been fabricated using a W/O emulsification with solvent evaporation technique. Microspheres were generated in high yield (80wgt%) and vancornycin incorporation, confirmed using the displacement of DSC thermograms, had no significant effect on microsphere size distribution (5-50 μm). The vancomycin encapsulation efficiency was high (>64%) and release profiles were characterized by a substantial initial burst release and a subsequent low-level sustained release extending up to 30 days depending upon the fabrication polymer, % vancornycin loading and incubation medium used. In both Hank's buffer and newborn calf serum the mean total cumulative release of vancomycin from microspheres increased significantly with theoretical percentage loading.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biocompatible Materials - administration & dosage</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>Cattle</subject><subject>Chemistry, Pharmaceutical</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lactic Acid - administration & dosage</subject><subject>Lactic Acid - chemistry</subject><subject>Lactic Acid - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>newborn calf serum</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>poly(D. L-lactide-co-glycolide)</subject><subject>Polyglycolic Acid - administration & dosage</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Polyglycolic Acid - pharmacokinetics</subject><subject>Polymers - administration & dosage</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacokinetics</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - chemistry</subject><subject>Vancomycin - pharmacokinetics</subject><subject>vancomycin incorporation and release</subject><subject>W/O emulsification</subject><issn>0265-2048</issn><issn>1464-5246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSbZJf0APBR9KaKFORx-WJdJLSb8CC-2hPfRkxtpx1kG2NpK3xf--WnYbCIGchHifd5h5GHvJ4VxysO9B6EqAsgYsgDZSPmELrrQqK6H0U7bY5WUGzDF7ntINAFTWiCN2ZJWWBqoF-301uhA3IeLUh7HAcVVE8oSJitAVfzCnw-z6sehiGIofwc9vPr0rlqVHN_UrKl0or_3sgs-ft8XQuxjSZk2R0il71qFP9OLwnrBfXz7_vPxWLr9_vbr8uCydkjCV0qKqea0dt4JsBQRckpHgjK5qS6YGIU2tpFGyahWRUtS2UFvRouTIW3nCzvZzNzHcbilNzdAnR97jSGGbmtrqrEfwDPI9uNsxReqaTewHjHPDodnpbB7ozJ1Xh-HbdqDVXePgL-evDzkmh76LWVif7jDBtVXWZuzDHuvHLsQB_4boV82Esw_xf0c-tsXFvfqa0E9rh5Gam7CNY9b7yA3_ABLooFo</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Atkins, T. W.</creator><creator>Peacock, S. J.</creator><creator>Yates, D. J.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Informa</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Incorporation and release of vancomycin from Poly(D, L-lactide-co-glycolide) microspheres</title><author>Atkins, T. W. ; Peacock, S. J. ; Yates, D. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-39a47176c192e950e013e830c86579e8702387438435b4ee44ebb0792ba31a1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biocompatible Materials - administration & dosage</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>Cattle</topic><topic>Chemistry, Pharmaceutical</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Lactic Acid - administration & dosage</topic><topic>Lactic Acid - chemistry</topic><topic>Lactic Acid - pharmacokinetics</topic><topic>Medical sciences</topic><topic>Microspheres</topic><topic>newborn calf serum</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>poly(D. L-lactide-co-glycolide)</topic><topic>Polyglycolic Acid - administration & dosage</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Polyglycolic Acid - pharmacokinetics</topic><topic>Polymers - administration & dosage</topic><topic>Polymers - chemistry</topic><topic>Polymers - pharmacokinetics</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - chemistry</topic><topic>Vancomycin - pharmacokinetics</topic><topic>vancomycin incorporation and release</topic><topic>W/O emulsification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atkins, T. W.</creatorcontrib><creatorcontrib>Peacock, S. J.</creatorcontrib><creatorcontrib>Yates, D. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of microencapsulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atkins, T. W.</au><au>Peacock, S. J.</au><au>Yates, D. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incorporation and release of vancomycin from Poly(D, L-lactide-co-glycolide) microspheres</atitle><jtitle>Journal of microencapsulation</jtitle><addtitle>J Microencapsul</addtitle><date>1998</date><risdate>1998</risdate><volume>15</volume><issue>1</issue><spage>31</spage><epage>44</epage><pages>31-44</pages><issn>0265-2048</issn><eissn>1464-5246</eissn><coden>JOMIEF</coden><abstract>Abstract
Spherical monolithic microspheres, with a honeycomb-like internal architecture, composed of PLCG 50:50 and PLCG 75:25 and containing a range of vancomycin loadings, have been fabricated using a W/O emulsification with solvent evaporation technique. Microspheres were generated in high yield (80wgt%) and vancornycin incorporation, confirmed using the displacement of DSC thermograms, had no significant effect on microsphere size distribution (5-50 μm). The vancomycin encapsulation efficiency was high (>64%) and release profiles were characterized by a substantial initial burst release and a subsequent low-level sustained release extending up to 30 days depending upon the fabrication polymer, % vancornycin loading and incubation medium used. In both Hank's buffer and newborn calf serum the mean total cumulative release of vancomycin from microspheres increased significantly with theoretical percentage loading.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>9463805</pmid><doi>10.3109/02652049809006833</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0265-2048 |
| ispartof | Journal of microencapsulation, 1998, Vol.15 (1), p.31-44 |
| issn | 0265-2048 1464-5246 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biocompatible Materials - administration & dosage Biocompatible Materials - chemistry Biocompatible Materials - pharmacokinetics Biological and medical sciences Buffers Cattle Chemistry, Pharmaceutical General pharmacology Hydrogen-Ion Concentration Lactic Acid - administration & dosage Lactic Acid - chemistry Lactic Acid - pharmacokinetics Medical sciences Microspheres newborn calf serum Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly(D. L-lactide-co-glycolide) Polyglycolic Acid - administration & dosage Polyglycolic Acid - chemistry Polyglycolic Acid - pharmacokinetics Polymers - administration & dosage Polymers - chemistry Polymers - pharmacokinetics Vancomycin - administration & dosage Vancomycin - chemistry Vancomycin - pharmacokinetics vancomycin incorporation and release W/O emulsification |
| title | Incorporation and release of vancomycin from Poly(D, L-lactide-co-glycolide) microspheres |
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