ANGIOGENESIS AND TUMOR METASTASIS

Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. These vessels provide the principal route by which tumor cells exit the primary tumor site and enter the circulation. For many tumors, the vascular density can provide a prognostic indicator of m...

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Veröffentlicht in:	Annual review of medicine 1998-01, Vol.49 (1), p.407-424
1. Verfasser:	Zetter, PhD, Bruce R
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis angiogenesis inhibitors Angiostatins Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biological and medical sciences Blood vessels Blood Vessels - pathology Breast cancer Cancer therapies cancer therapy Chemotherapy Clinical Trials as Topic Collagen - adverse effects Collagen - physiology Collagen - therapeutic use Drug Resistance, Neoplasm Endostatins Endothelial Growth Factors - physiology Fibroblast Growth Factors - physiology Fibroblasts Humans Incidence invasion Medical prognosis Medical sciences Metastasis Neoplasm Metastasis - pathology Neoplasm Metastasis - physiopathology Neoplasms - blood supply Neoplastic Cells, Circulating - pathology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Peptide Fragments - adverse effects Peptide Fragments - physiology Peptide Fragments - therapeutic use Pharmacology. Drug treatments Plasminogen - adverse effects Plasminogen - physiology Plasminogen - therapeutic use Prognosis Toxicity tumor dormancy Tumors Vascular endothelial growth factor
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