Cardiovascular adaptations to 10 days of cycle exercise
Constance M. Mier, Michael J. Turner, Ali A. Ehsani, and Robert J. Spina Section of Applied Physiology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110 Received 18 November 1996; accepted in final form 23 July 1997. Mier, Constance M., Michael J. ...
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| creator | Mier, Constance M Turner, Michael J Ehsani, Ali A Spina, Robert J |
| description | Constance M.
Mier,
Michael J.
Turner,
Ali A.
Ehsani, and
Robert J.
Spina
Section of Applied Physiology, Department of Internal
Medicine, Washington University School of Medicine, St. Louis,
Missouri 63110
Received 18 November 1996; accepted in final form 23 July 1997.
Mier, Constance M., Michael J. Turner, Ali A. Ehsani, and
Robert J. Spina. Cardiovascular adaptations to 10 days of cycle
exercise. J. Appl. Physiol. 83(6):
1900-1906, 1997. We hypothesized that 10 days of training would
enhance cardiac output (CO) and stroke volume (SV) during peak exercise
and increase the inotropic response to -adrenergic stimulation. Ten
subjects [age 26 ± 2 (SE) yr] trained on a cycle
ergometer for 10 days. At peak exercise, training increased
O 2 uptake, CO, and SV
( P |
| doi_str_mv | 10.1152/jappl.1997.83.6.1900 |
| format | Article |
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Mier,
Michael J.
Turner,
Ali A.
Ehsani, and
Robert J.
Spina
Section of Applied Physiology, Department of Internal
Medicine, Washington University School of Medicine, St. Louis,
Missouri 63110
Received 18 November 1996; accepted in final form 23 July 1997.
Mier, Constance M., Michael J. Turner, Ali A. Ehsani, and
Robert J. Spina. Cardiovascular adaptations to 10 days of cycle
exercise. J. Appl. Physiol. 83(6):
1900-1906, 1997. We hypothesized that 10 days of training would
enhance cardiac output (CO) and stroke volume (SV) during peak exercise
and increase the inotropic response to -adrenergic stimulation. Ten
subjects [age 26 ± 2 (SE) yr] trained on a cycle
ergometer for 10 days. At peak exercise, training increased
O 2 uptake, CO, and SV
( P < 0.001). Left ventricular (LV)
size and function at rest were assessed with two-dimensional echocardiography before (baseline) and after atropine injection (1.0 mg) and during four graded doses of dobutamine. LV end-diastolic diameter increased with training ( P < 0.02), whereas LV wall thickness was unchanged. LV contractile
performance was assessed by relating fractional shortening (FS) to the
estimated end-systolic wall stress
( ES ). Training increased the
slope of the FS- ES relationship ( P < 0.05), indicating enhanced
systolic function. The increase in slope correlated with increases in
CO ( r = 0.71,
P < 0.05) and SV
( r = 0.70,
P < 0.05). The increase in blood
volume also correlated with increases in CO
( r = 0.80, P < 0.01) and SV ( r = 0.85, P < 0.004). These data
show that 10 days of training enhance the inotropic response to
-adrenergic stimulation, associated with increases in CO and SV
during peak exercise.
short-term training; left ventricular function; cardiac output; stroke volume
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society]]></description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1997.83.6.1900</identifier><identifier>PMID: 9390961</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adrenergic beta-Agonists - pharmacology ; Bicycling ; Biological and medical sciences ; Cardiac Output - drug effects ; Cardiac Output - physiology ; Catecholamines - blood ; Exercise - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; Hemodynamics - physiology ; Humans ; Myocardial Contraction - physiology ; Oxygen Consumption - drug effects ; Oxygen Consumption - physiology ; Physical Fitness - physiology ; Plasma Volume - drug effects ; Plasma Volume - physiology ; Space life sciences ; Stroke Volume - drug effects ; Stroke Volume - physiology ; Ventricular Function, Left - drug effects ; Ventricular Function, Left - physiology ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>Journal of applied physiology (1985), 1997-12, Vol.83 (6), p.1900-1906</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-b5e71fc8c55115449f976a436e35b8e6299d228c917f44191e02172bfcd68dcd3</citedby><cites>FETCH-LOGICAL-c506t-b5e71fc8c55115449f976a436e35b8e6299d228c917f44191e02172bfcd68dcd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2108628$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9390961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mier, Constance M</creatorcontrib><creatorcontrib>Turner, Michael J</creatorcontrib><creatorcontrib>Ehsani, Ali A</creatorcontrib><creatorcontrib>Spina, Robert J</creatorcontrib><title>Cardiovascular adaptations to 10 days of cycle exercise</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description><![CDATA[Constance M.
Mier,
Michael J.
Turner,
Ali A.
Ehsani, and
Robert J.
Spina
Section of Applied Physiology, Department of Internal
Medicine, Washington University School of Medicine, St. Louis,
Missouri 63110
Received 18 November 1996; accepted in final form 23 July 1997.
Mier, Constance M., Michael J. Turner, Ali A. Ehsani, and
Robert J. Spina. Cardiovascular adaptations to 10 days of cycle
exercise. J. Appl. Physiol. 83(6):
1900-1906, 1997. We hypothesized that 10 days of training would
enhance cardiac output (CO) and stroke volume (SV) during peak exercise
and increase the inotropic response to -adrenergic stimulation. Ten
subjects [age 26 ± 2 (SE) yr] trained on a cycle
ergometer for 10 days. At peak exercise, training increased
O 2 uptake, CO, and SV
( P < 0.001). Left ventricular (LV)
size and function at rest were assessed with two-dimensional echocardiography before (baseline) and after atropine injection (1.0 mg) and during four graded doses of dobutamine. LV end-diastolic diameter increased with training ( P < 0.02), whereas LV wall thickness was unchanged. LV contractile
performance was assessed by relating fractional shortening (FS) to the
estimated end-systolic wall stress
( ES ). Training increased the
slope of the FS- ES relationship ( P < 0.05), indicating enhanced
systolic function. The increase in slope correlated with increases in
CO ( r = 0.71,
P < 0.05) and SV
( r = 0.70,
P < 0.05). The increase in blood
volume also correlated with increases in CO
( r = 0.80, P < 0.01) and SV ( r = 0.85, P < 0.004). These data
show that 10 days of training enhance the inotropic response to
-adrenergic stimulation, associated with increases in CO and SV
during peak exercise.
short-term training; left ventricular function; cardiac output; stroke volume
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society]]></description><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Bicycling</subject><subject>Biological and medical sciences</subject><subject>Cardiac Output - drug effects</subject><subject>Cardiac Output - physiology</subject><subject>Catecholamines - blood</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Myocardial Contraction - physiology</subject><subject>Oxygen Consumption - drug effects</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical Fitness - physiology</subject><subject>Plasma Volume - drug effects</subject><subject>Plasma Volume - physiology</subject><subject>Space life sciences</subject><subject>Stroke Volume - drug effects</subject><subject>Stroke Volume - physiology</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Ventricular Function, Left - physiology</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1uEzEUhS0EKqHwBiDNAiE2k_p6_LtEES1Ilbpp15bjn2YqJx7sGdp5G56FJ6tDo8AGdXWvdM659-hD6D3gJQAjZ3dmGOISlBJL2S153TB-gRZVIi1wDC_RQgqGW8GkeI3elHKHMVDK4ASdqE5hxWGB5Mpk16efptgpmtwYZ4bRjH3alWZMDeDfv5yZS5NCY2cbfeMffLZ98W_Rq2Bi8e8O8xTdnH-9Xn1rL68uvq--XLaWYT62a-YFBCstY7U0pSoowQ3tuO_YWnpOlHKESKtABEpBgccEBFkH67h01nWn6NPT3SGnH5Mvo972xfoYzc6nqWihKGcY5LNGkJJR4LQa6ZPR5lRK9kEPud-aPGvAek9W_yGr92S17DTXe7I19uFwf1pvvTuGDiir_vGgV5Ymhmx2ldPRRgBLTuTf75v-dnPfZ6-HzVz6FNPtrM-nGK_9w7hvcPysBxdq7PP_Y9X9T9FHf2aiww</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Mier, Constance M</creator><creator>Turner, Michael J</creator><creator>Ehsani, Ali A</creator><creator>Spina, Robert J</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>Cardiovascular adaptations to 10 days of cycle exercise</title><author>Mier, Constance M ; Turner, Michael J ; Ehsani, Ali A ; Spina, Robert J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-b5e71fc8c55115449f976a436e35b8e6299d228c917f44191e02172bfcd68dcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>Bicycling</topic><topic>Biological and medical sciences</topic><topic>Cardiac Output - drug effects</topic><topic>Cardiac Output - physiology</topic><topic>Catecholamines - blood</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Myocardial Contraction - physiology</topic><topic>Oxygen Consumption - drug effects</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical Fitness - physiology</topic><topic>Plasma Volume - drug effects</topic><topic>Plasma Volume - physiology</topic><topic>Space life sciences</topic><topic>Stroke Volume - drug effects</topic><topic>Stroke Volume - physiology</topic><topic>Ventricular Function, Left - drug effects</topic><topic>Ventricular Function, Left - physiology</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mier, Constance M</creatorcontrib><creatorcontrib>Turner, Michael J</creatorcontrib><creatorcontrib>Ehsani, Ali A</creatorcontrib><creatorcontrib>Spina, Robert J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mier, Constance M</au><au>Turner, Michael J</au><au>Ehsani, Ali A</au><au>Spina, Robert J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular adaptations to 10 days of cycle exercise</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>83</volume><issue>6</issue><spage>1900</spage><epage>1906</epage><pages>1900-1906</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract><![CDATA[Constance M.
Mier,
Michael J.
Turner,
Ali A.
Ehsani, and
Robert J.
Spina
Section of Applied Physiology, Department of Internal
Medicine, Washington University School of Medicine, St. Louis,
Missouri 63110
Received 18 November 1996; accepted in final form 23 July 1997.
Mier, Constance M., Michael J. Turner, Ali A. Ehsani, and
Robert J. Spina. Cardiovascular adaptations to 10 days of cycle
exercise. J. Appl. Physiol. 83(6):
1900-1906, 1997. We hypothesized that 10 days of training would
enhance cardiac output (CO) and stroke volume (SV) during peak exercise
and increase the inotropic response to -adrenergic stimulation. Ten
subjects [age 26 ± 2 (SE) yr] trained on a cycle
ergometer for 10 days. At peak exercise, training increased
O 2 uptake, CO, and SV
( P < 0.001). Left ventricular (LV)
size and function at rest were assessed with two-dimensional echocardiography before (baseline) and after atropine injection (1.0 mg) and during four graded doses of dobutamine. LV end-diastolic diameter increased with training ( P < 0.02), whereas LV wall thickness was unchanged. LV contractile
performance was assessed by relating fractional shortening (FS) to the
estimated end-systolic wall stress
( ES ). Training increased the
slope of the FS- ES relationship ( P < 0.05), indicating enhanced
systolic function. The increase in slope correlated with increases in
CO ( r = 0.71,
P < 0.05) and SV
( r = 0.70,
P < 0.05). The increase in blood
volume also correlated with increases in CO
( r = 0.80, P < 0.01) and SV ( r = 0.85, P < 0.004). These data
show that 10 days of training enhance the inotropic response to
-adrenergic stimulation, associated with increases in CO and SV
during peak exercise.
short-term training; left ventricular function; cardiac output; stroke volume
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society]]></abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9390961</pmid><doi>10.1152/jappl.1997.83.6.1900</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of applied physiology (1985), 1997-12, Vol.83 (6), p.1900-1906 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_2108628 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adrenergic beta-Agonists - pharmacology Bicycling Biological and medical sciences Cardiac Output - drug effects Cardiac Output - physiology Catecholamines - blood Exercise - physiology Female Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Hemodynamics - physiology Humans Myocardial Contraction - physiology Oxygen Consumption - drug effects Oxygen Consumption - physiology Physical Fitness - physiology Plasma Volume - drug effects Plasma Volume - physiology Space life sciences Stroke Volume - drug effects Stroke Volume - physiology Ventricular Function, Left - drug effects Ventricular Function, Left - physiology Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | Cardiovascular adaptations to 10 days of cycle exercise |
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