Efficacy and safety of dabigatran etexilate for the prevention of venous thromboembolism following total hip or knee arthroplasty - A meta-analysis

Dabigatran etexilate has been investigated in three phase III trials for the prevention of venous thromboembolism (VTE). Health technology assessment agencies increasingly require meta-analyses of all relevant evidence for an intervention, if appropriate. The objective of this study was to perform a...

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Veröffentlicht in:	Thrombosis and haemostasis 2009-01, Vol.101 (1), p.77-85
Hauptverfasser:	WOLOWACZ, Sorrel E, ROSKELL, Neil S, PLUMB, Jonathan M, CAPRINI, Joseph A, ERIKSSON, Bengt I
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration Administration, Oral anticoagulants Anticoagulants - administration & dosage Anticoagulants - adverse effects Anticoagulants - therapeutic use Anticoagulants/administration & dosage/adverse effects/therapeutic use Arthroplasty Arthroplasty, Replacement, Hip - adverse effects Arthroplasty, Replacement, Knee - adverse effects Benzimidazoles - administration & dosage Benzimidazoles - adverse effects Benzimidazoles - therapeutic use Benzimidazoles/administration & dosage/adverse effects/therapeutic use Biological and medical sciences Blood coagulation. Blood cells Clinical Trials Clinical Trials, Phase III as Topic Dabigatran Drug Administration Schedule Embolism Enoxaparin - administration & dosage Enoxaparin - adverse effects Enoxaparin - therapeutic use Enoxaparin/administration & dosage/adverse effects/therapeutic use Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Hemorrhage - chemically induced Hip/adverse effects Humans Kirurgi Knee/adverse effects Medical sciences Meta-analysis Molecular and cellular biology Oral Phase III as Topic Platelet diseases and coagulopathies prophylaxis Pyridines - administration & dosage Pyridines - adverse effects Pyridines - therapeutic use Pyridines/administration & dosage/adverse effects/therapeutic use Replacement Risk Assessment Surgery thrombosis Treatment Outcome Venous Thromboembolism - etiology Venous Thromboembolism - mortality Venous Thromboembolism - prevention & control Venous Thromboembolism/etiology/mortality/prevention & control
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