MEKK3 Initiates Transforming Growth Factor β2–Dependent Epithelial-to-Mesenchymal Transition During Endocardial Cushion Morphogenesis

Congenital heart defects occur at a rate of 5% and are the most prevalent birth defects. A better understanding of the complex signaling networks regulating heart development is necessary to improve repair strategies for congenital heart defects. The mitogen-activated protein 3 kinase (MEKK3) is imp...

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Veröffentlicht in:	Circulation research 2008-12, Vol.103 (12), p.1430-1440
Hauptverfasser:	Stevens, Mark V, Broka, Derrick M, Parker, Patti, Rogowitz, Elisa, Vaillancourt, Richard R, Camenisch, Todd D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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