Synthesis of FF8181-A

Synthesis of FF8181-A

Both enantiomers of FF8181-A were synthesized through optical resolution from the known Diels-Alder reaction product in 15 steps. The absolute configuration of the natural product was determined to be 1S,5S,5aS,9aS,9bS.

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Bibliographische Detailangaben
Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-10, Vol.72 (10), p.2708-2715
Hauptverfasser: Kobayshi, N.(Tokyo Univ. (Japan)), Kuniyosi, H, Ishigami, K, Watanabe, H
Format: Artikel
Sprache:eng
Schlagworte:
ANALYTICAL METHODS
Biological and medical sciences
Caprylates - chemical synthesis
Caprylates - chemistry
CARDIOVASCULAR AGENTS
CHEMICAL STRUCTURE
CHEMICAL SYNTHESIS
Diels-Alder reaction
ESTRUCTURA QUIMICA
FF8181-A
Fundamental and applied biological sciences. Psychology
MEDICAMENTOS CARDIOVASCULARES
MODIFICATEUR CARDIOVASCULAIRE
Molecular Structure
OPTICAL PROPERTIES
optical resolution
Organic Chemicals - chemical synthesis
Organic Chemicals - chemistry
PROPIEDADES OPTICAS
PROPRIETE OPTIQUE
Sesquiterpenes - chemical synthesis
Sesquiterpenes - chemistry
SESQUITERPENOIDE
SESQUITERPENOIDS
SESQUITERPENOS
SINTESIS QUIMICA
STRUCTURE CHIMIQUE
SYNTHESE CHIMIQUE
TECHNIQUE ANALYTIQUE
TECNICAS ANALITICAS
β-catenin
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Beschreibung
Zusammenfassung:Both enantiomers of FF8181-A were synthesized through optical resolution from the known Diels-Alder reaction product in 15 steps. The absolute configuration of the natural product was determined to be 1S,5S,5aS,9aS,9bS.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.80351