Patients suffering from acute graft-versus-host disease after bone-marrow transplantation have functional CD4+ CD25hi Foxp3+ regulatory T cells

Abstract Acute Graft-Versus-Host Disease (aGVHD), mediated by CD4+ and CD8+ effector T cells, is a life-threatening complication in hematopoietic stem cell (HSC) transplantation. Naturally-occurring CD4+ CD25hi (Foxp3+ ) regulatory T cells (Treg ) have been shown to modulate tolerance to aGVHD in mu...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2008, Vol.129 (2), p.241-248
Hauptverfasser:	Noël, G, Bruniquel, D, Birebent, B, DeGuibert, S, Grosset, J-M, Bernard, M, Dauriac, C, Chevallier, P, Lamy-de-la-chapelle, T, Semana, G, Brinster, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology
Online-Zugang:	Volltext
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