Discovery of a Novel Series of Benzoic Acid Derivatives as Potent and Selective Human β3 Adrenergic Receptor Agonists with Good Oral Bioavailability. 3. Phenylethanolaminotetraline (PEAT) Skeleton Containing Biphenyl or Biphenyl Ether Moiety

We designed a series of benzoic acid derivatives containing the biphenyl ether or biphenyl template on the RHS and a phenylethanolaminotetraline (PEAT) skeleton, which was prepared by highly stereoselective synthesis, to generate two structurally different lead compounds (10c, 10m) with a good balan...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-08, Vol.51 (15), p.4804-4822
Hauptverfasser:	Imanishi, Masashi, Nakajima, Yutaka, Tomishima, Yasuyo, Hamashima, Hitoshi, Washizuka, Kenichi, Sakurai, Minoru, Matsui, Shigeo, Imamura, Emiko, Ueshima, Koji, Yamamoto, Takao, Yamamoto, Nobuhiro, Ishikawa, Hirofumi, Nakano, Keiko, Unami, Naoko, Hamada, Kaori, Matsumura, Yasuhiro, Takamura, Fujiko, Hattori, Kouji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catecholaminergic system General and cellular metabolism. Vitamins Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments
Online-Zugang:	Volltext
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