More than one intracellular processing bottleneck delays the secretion of coagulation factor VII

Summary Coagulation factorVII (FVII) is a vitamin K-dependent glycoprotein that undergoes extensive post-translational modification prior to secretion. Secretion of FVII proteins from producer cells is a slow process. To identify bottlenecks for the transport of FVII through the secretory pathway of...

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Veröffentlicht in:	Thrombosis and haemostasis 2008-08, Vol.100 (2), p.204-210
Hauptverfasser:	Bolt, Gert, Kristensen, Claus, Steenstrup, Thomas D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Coagulation, Fibrinolysis and Cellular Haemostasis Blood coagulation. Blood cells Carboxylic Acids - metabolism CHO Cells Cricetinae Cricetulus Endoplasmic Reticulum - metabolism Factor VII Factor VII - metabolism Factor VII - secretion Fundamental and applied biological sciences. Psychology gammacarboxylation glycosylation Golgi Apparatus - metabolism Heat-Shock Proteins - metabolism Hematologic and hematopoietic diseases Humans Medical sciences Molecular and cellular biology Molecular Chaperones - metabolism Platelet diseases and coagulopathies Polysaccharides - metabolism post-translational protein processing Protein Transport - physiology Time Factors
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