Vinblastine Pharmacokinetics in Patients with Non-Small Cell Lung Cancer Given Cisplatin

Abstract The pharmacokinetics of vinblastine were studied in 16 patients with non-small cell lung cancer after a bolus intravenous dose of 3 mg/m2 given before or after cisplatin (100 mg/m2). Venous blood was collected at 0, 10, and 36 hr for analysis by radio-immunoassay. The mean plasma vinblastin...

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Veröffentlicht in:	Cancer investigation 1999, Vol.17 (7), p.479-485
Hauptverfasser:	Links, Matthew, Watson, Shaun, Lethlean, Keith, Aherne, Wynne, Kirsten, Fred, Clarke, Stephen, Law, Matthew, Friedlander, Michael, Galettis, Peter, McKeage, Mark J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Chemotherapy Cisplatin - administration & dosage Drug Administration Schedule Female Humans Injections, Intravenous Leukocyte Count - drug effects Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Male Medical sciences Middle Aged Neoplasm Staging Neutrophils - drug effects Pharmacology. Drug treatments Radioimmunoassay Vinblastine - administration & dosage Vinblastine - adverse effects Vinblastine - pharmacokinetics Vinblastine - therapeutic use
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