Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII

Summary Catabolism of coagulation factorVIII (FVIII) is mediated by lowdensity lipoprotein receptor-related protein (LRP). The ligandbinding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. FVIII contains two major LRP-binding sites located...

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Veröffentlicht in:	Thrombosis and haemostasis 2007-12, Vol.98 (6), p.1170-1181
Hauptverfasser:	Sarafanov, Andrey G., Makogonenko, Evgeny M., Andersen, Olav M., Mikhailenko, Irina A., Ananyeva, Natalya M., Khrenov, Alexey V., Shima, Midori, Strickland, Dudley K., Saenko, Evgueni L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baculoviridae - genetics Baculoviridae - metabolism Binding, Competitive Biological and medical sciences Blood Coagulation, Fibrinolysis and Cellular Haemostasis Blood coagulation. Blood cells Cell Line Coagulation factorVIII Endocytosis Factor VIII - chemistry Factor VIII - genetics Factor VIII - metabolism Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Humans Iodine Radioisotopes LDL-Receptor Related Proteins - chemistry LDL-Receptor Related Proteins - genetics LDL-Receptor Related Proteins - metabolism Ligands low-density lipoprotein receptor-related protein Medical sciences Mice Mice, Inbred BALB C Molecular and cellular biology Molecular Chaperones - metabolism Mutagenesis, Site-Directed Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Platelet diseases and coagulopathies Point Mutation Protein Binding Protein Conformation Protein Structure, Tertiary Surface Plasmon Resonance Time Factors
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