Hypotensive Properties of the Protein Kinase Inhibitor, Staurosporine, in Normotensive and Spontaneously Hypertensive Rats

The protein kinase inhibitor, staurosporine, was examined for hemodynamic actions in conscious rats and for its effects on isolated vascular smooth muscle. In conscious normotensive rats, staurosporine, 0.1 to 1.0 mg/kg intravenous, produced a dose-related decrease in blood pressure. Doses of 0.1 an...

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Veröffentlicht in:	Clinical and experimental hypertension (1993) 1991, Vol.A13 (2), p.219-234
Hauptverfasser:	Secrest, Roberta J., Williams, Patricia, Bonjouklian, Rosanne, Modlin, Deah, Firman, Kenneth, Turk, John, Cohen, Marlene L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Aorta Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Blood Pressure - drug effects Cardiology. Vascular system Decerebrate State Experimental diseases Heart Rate Heart Rate - drug effects Hemodynamics - drug effects Hypotension - chemically induced Medical sciences Muscle, Smooth, Vascular - drug effects Protein Kinase Inhibitors Rat Rats Rats, Inbred SHR - physiology Rats, Inbred Strains Reference Values Serotonin - pharmacology Staurosporine Vasoconstriction - drug effects
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