Distortion Product Oto-acoustic Emissions in Andean Children and Adults with Chronic Lead Intoxication
Neuroauditory disorders and sensory-neural hearing loss have been suggested as possible etiologic factors in the neurodevelopmental learning disabilities attributed to lead (Pb) intoxication. However, studies relating hearing loss to Pb poisoning have presented disparate results, suggesting that aud...
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| Veröffentlicht in: | Acta oto-laryngologica 1999, Vol.119 (6), p.652-658 |
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| description | Neuroauditory disorders and sensory-neural hearing loss have been suggested as possible etiologic factors in the neurodevelopmental learning disabilities attributed to lead (Pb) intoxication. However, studies relating hearing loss to Pb poisoning have presented disparate results, suggesting that auditory sensitivity may not be a reliable marker of Pb intoxication. Oto-acoustic emissions, sounds that can be recorded non-invasively from the ear canal and are preneural responses of the outer hair cells of the inner ear, have been found to be diminished in ears exposed to some toxic agents. In the current study, distortion product oto-acoustic emissions (DPOAEs) were obtained from 28 ears of 14 children and 10 ears of 5 adults living in a highly Pb-contaminated environment in remote villages in the Andes Mountains of Ecuador. Blood lead (PbB) levels for the children (ages: 5-14 years) ranged from 33.4 to 118.2 |
| doi_str_mv | 10.1080/00016489950180586 |
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However, studies relating hearing loss to Pb poisoning have presented disparate results, suggesting that auditory sensitivity may not be a reliable marker of Pb intoxication. Oto-acoustic emissions, sounds that can be recorded non-invasively from the ear canal and are preneural responses of the outer hair cells of the inner ear, have been found to be diminished in ears exposed to some toxic agents. In the current study, distortion product oto-acoustic emissions (DPOAEs) were obtained from 28 ears of 14 children and 10 ears of 5 adults living in a highly Pb-contaminated environment in remote villages in the Andes Mountains of Ecuador. 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Toxic occupational diseases ; Child ; Chronic Disease ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Ecuador ; Evoked Potentials, Auditory, Brain Stem - drug effects ; Evoked Potentials, Auditory, Brain Stem - physiology ; Female ; Humans ; Lead - blood ; Lead Poisoning, Nervous System, Adult - diagnosis ; Lead Poisoning, Nervous System, Adult - physiopathology ; Lead Poisoning, Nervous System, Childhood - diagnosis ; Lead Poisoning, Nervous System, Childhood - physiopathology ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Metals and various inorganic compounds ; Middle Aged ; Non tumoral diseases ; Otoacoustic Emissions, Spontaneous - drug effects ; Otoacoustic Emissions, Spontaneous - physiology ; Otorhinolaryngology. Stomatology ; Rural Population ; Statistics, Nonparametric ; Toxicology</subject><ispartof>Acta oto-laryngologica, 1999, Vol.119 (6), p.652-658</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-5b5e9b70452499ea339ee0ff982e08a4ab634831c0af485e45903a5de41ae7003</citedby><cites>FETCH-LOGICAL-c517t-5b5e9b70452499ea339ee0ff982e08a4ab634831c0af485e45903a5de41ae7003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00016489950180586$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00016489950180586$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1982948$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10586997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1929357$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Buchanan, Leo H.</creatorcontrib><title>Distortion Product Oto-acoustic Emissions in Andean Children and Adults with Chronic Lead Intoxication</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>Neuroauditory disorders and sensory-neural hearing loss have been suggested as possible etiologic factors in the neurodevelopmental learning disabilities attributed to lead (Pb) intoxication. However, studies relating hearing loss to Pb poisoning have presented disparate results, suggesting that auditory sensitivity may not be a reliable marker of Pb intoxication. Oto-acoustic emissions, sounds that can be recorded non-invasively from the ear canal and are preneural responses of the outer hair cells of the inner ear, have been found to be diminished in ears exposed to some toxic agents. In the current study, distortion product oto-acoustic emissions (DPOAEs) were obtained from 28 ears of 14 children and 10 ears of 5 adults living in a highly Pb-contaminated environment in remote villages in the Andes Mountains of Ecuador. Blood lead (PbB) levels for the children (ages: 5-14 years) ranged from 33.4 to 118.2</description><subject>Adolescent</subject><subject>Adult</subject><subject>Audiometry - methods</subject><subject>Audiometry - statistics & numerical data</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Ecuador</subject><subject>Evoked Potentials, Auditory, Brain Stem - drug effects</subject><subject>Evoked Potentials, Auditory, Brain Stem - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Lead - blood</subject><subject>Lead Poisoning, Nervous System, Adult - diagnosis</subject><subject>Lead Poisoning, Nervous System, Adult - physiopathology</subject><subject>Lead Poisoning, Nervous System, Childhood - diagnosis</subject><subject>Lead Poisoning, Nervous System, Childhood - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Metals and various inorganic compounds</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Otoacoustic Emissions, Spontaneous - drug effects</subject><subject>Otoacoustic Emissions, Spontaneous - physiology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Rural Population</subject><subject>Statistics, Nonparametric</subject><subject>Toxicology</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vFCEYh4nR2HX1A3gxHLyOwgAzEL1s1qpNNmkP9Tx5F5gsdRY2wGTbby-T2Vqbxp748z7PG15-CL2n5BMlknwmhNCGS6UEoZII2bxAC9oIWtW1oC_RYqpXE3CG3qR0Mx2VFK_RGZ1gpdoF6r-5lEPMLnh8FYMZdcaXOVSgw5iy0_h871Iq1YSdxytvLHi83rnBROsxeINXZhxywkeXd6UQgy_SxoLBFz6HW6dh6v0WvephSPbdaV2iX9_Pr9c_q83lj4v1alNpQdtcia2watsSLmqulAXGlLWk75WsLZHAYdswLhnVBHouheVCEQbCWE7BtoSwJarmvuloD-O2O0S3h3jXBXDd6ep32dmuIYy3qvDtf_lD-Y4H6V6kqlZMtMWks6ljSCna_q9LSTel0z1JpzgfZqe03FvzjzHHUYCPJwCShqGP4LVLD1z5B1XmX6KvM-Z8H-IejiEOpstwN4R477DnnvHlkb6zMOSdhmi7mzBGXwJ6Zog_Pp6-ag</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Buchanan, Leo H.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>1999</creationdate><title>Distortion Product Oto-acoustic Emissions in Andean Children and Adults with Chronic Lead Intoxication</title><author>Buchanan, Leo H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-5b5e9b70452499ea339ee0ff982e08a4ab634831c0af485e45903a5de41ae7003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Audiometry - methods</topic><topic>Audiometry - statistics & numerical data</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Ecuador</topic><topic>Evoked Potentials, Auditory, Brain Stem - drug effects</topic><topic>Evoked Potentials, Auditory, Brain Stem - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Lead - blood</topic><topic>Lead Poisoning, Nervous System, Adult - diagnosis</topic><topic>Lead Poisoning, Nervous System, Adult - physiopathology</topic><topic>Lead Poisoning, Nervous System, Childhood - diagnosis</topic><topic>Lead Poisoning, Nervous System, Childhood - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Metals and various inorganic compounds</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Otoacoustic Emissions, Spontaneous - drug effects</topic><topic>Otoacoustic Emissions, Spontaneous - physiology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Rural Population</topic><topic>Statistics, Nonparametric</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buchanan, Leo H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buchanan, Leo H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distortion Product Oto-acoustic Emissions in Andean Children and Adults with Chronic Lead Intoxication</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>1999</date><risdate>1999</risdate><volume>119</volume><issue>6</issue><spage>652</spage><epage>658</epage><pages>652-658</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>Neuroauditory disorders and sensory-neural hearing loss have been suggested as possible etiologic factors in the neurodevelopmental learning disabilities attributed to lead (Pb) intoxication. However, studies relating hearing loss to Pb poisoning have presented disparate results, suggesting that auditory sensitivity may not be a reliable marker of Pb intoxication. Oto-acoustic emissions, sounds that can be recorded non-invasively from the ear canal and are preneural responses of the outer hair cells of the inner ear, have been found to be diminished in ears exposed to some toxic agents. In the current study, distortion product oto-acoustic emissions (DPOAEs) were obtained from 28 ears of 14 children and 10 ears of 5 adults living in a highly Pb-contaminated environment in remote villages in the Andes Mountains of Ecuador. Blood lead (PbB) levels for the children (ages: 5-14 years) ranged from 33.4 to 118.2</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>10586997</pmid><doi>10.1080/00016489950180586</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Audiometry - methods Audiometry - statistics & numerical data Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Child Chronic Disease Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ecuador Evoked Potentials, Auditory, Brain Stem - drug effects Evoked Potentials, Auditory, Brain Stem - physiology Female Humans Lead - blood Lead Poisoning, Nervous System, Adult - diagnosis Lead Poisoning, Nervous System, Adult - physiopathology Lead Poisoning, Nervous System, Childhood - diagnosis Lead Poisoning, Nervous System, Childhood - physiopathology Male Medical sciences Medicin och hälsovetenskap Metals and various inorganic compounds Middle Aged Non tumoral diseases Otoacoustic Emissions, Spontaneous - drug effects Otoacoustic Emissions, Spontaneous - physiology Otorhinolaryngology. Stomatology Rural Population Statistics, Nonparametric Toxicology |
| title | Distortion Product Oto-acoustic Emissions in Andean Children and Adults with Chronic Lead Intoxication |
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