α 1-Acid glycoprotein column in the high-performance liquid chromatographic analysis of some groups of chiral drugs
The usefulness of the α 1-acid glycoprotein (Chiral—AGP) column in the analysis of chiral drugs and related materials is illustrated in three different fields. Excellent separations of the enantiomers of pharmacologically active α-ethyl benzhydrols such as 3-trifluoromethyl-α-ethyl benzhydrol (flume...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1990, Vol.8 (8), p.837-842 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | GOÊROÊG, S HERENYI, B |
| description | The usefulness of the α
1-acid glycoprotein (Chiral—AGP) column in the analysis of chiral drugs and related materials is illustrated in three different fields. Excellent separations of the enantiomers of pharmacologically active α-ethyl benzhydrols such as 3-trifluoromethyl-α-ethyl benzhydrol (flumecinol) and 11 other derivatives are described. The enantiomers of
N-protected amino-acid esters or amides can also be separated. The effect of the derivatization of the free α-amino group on the resolution of the enantiomers is exemplified by the formylation of alanine benzyl ester. As an example of the use of the method for the estimation of the optical purity of chiral drugs, the determination of the “
cis(−)” impurity in “
cis(+)” diltiazem is presented. |
| doi_str_mv | 10.1016/0731-7085(90)80129-D |
| format | Article |
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1-acid glycoprotein (Chiral—AGP) column in the analysis of chiral drugs and related materials is illustrated in three different fields. Excellent separations of the enantiomers of pharmacologically active α-ethyl benzhydrols such as 3-trifluoromethyl-α-ethyl benzhydrol (flumecinol) and 11 other derivatives are described. The enantiomers of
N-protected amino-acid esters or amides can also be separated. The effect of the derivatization of the free α-amino group on the resolution of the enantiomers is exemplified by the formylation of alanine benzyl ester. As an example of the use of the method for the estimation of the optical purity of chiral drugs, the determination of the “
cis(−)” impurity in “
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1-acid glycoprotein (Chiral—AGP) column in the analysis of chiral drugs and related materials is illustrated in three different fields. Excellent separations of the enantiomers of pharmacologically active α-ethyl benzhydrols such as 3-trifluoromethyl-α-ethyl benzhydrol (flumecinol) and 11 other derivatives are described. The enantiomers of
N-protected amino-acid esters or amides can also be separated. The effect of the derivatization of the free α-amino group on the resolution of the enantiomers is exemplified by the formylation of alanine benzyl ester. As an example of the use of the method for the estimation of the optical purity of chiral drugs, the determination of the “
cis(−)” impurity in “
cis(+)” diltiazem is presented.</description><subject>amino acid derivatives</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>chiral HPLC</subject><subject>diltiazem</subject><subject>enantiomeric separation</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>α 1-Acid glycoprotein</subject><subject>α-ethyl benzhydrols</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNo9kM1KxDAQx4MouK6-gYdcBD1EJ-lH0ouw7PoFC14UvIWYpm2kbWrSCvtYvojPZHZXPM384TfDzA-hcwrXFGh-AzyhhIPILgu4EkBZQVYHaEYFTwjL07dDNPtHjtFJCB8AkNEinaHx5xtTstC2xHW70W7wbjS2x9q1U9fj2I2NwY2tGzIYXznfqV4b3NrPKY7oxrtOja72amisxqpX7SbYgF2Fg-sMrr2bhl3UjfWqxaWf6nCKjirVBnP2V-fo9f7uZflI1s8PT8vFmhjKYSTvTLO0KDhoBabMjMhNziChOos5qXKqVWkYB0bzNIkE8FQLIUotaAVlliVzdLHfO6igVVv5eLsNcvC2U34jacHTVDAeuds9Z-IxX9Z4GbQ18c_SeqNHWTorKcita7kVKbciZQFy51qukl-vGnTG</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>GOÊROÊG, S</creator><creator>HERENYI, B</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope></search><sort><creationdate>1990</creationdate><title>α 1-Acid glycoprotein column in the high-performance liquid chromatographic analysis of some groups of chiral drugs</title><author>GOÊROÊG, S ; HERENYI, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e170t-b2c249970ca0ed5e86e62031c5a0e3f61cade270216430ed074c888dc81f0d553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>amino acid derivatives</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>chiral HPLC</topic><topic>diltiazem</topic><topic>enantiomeric separation</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>α 1-Acid glycoprotein</topic><topic>α-ethyl benzhydrols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOÊROÊG, S</creatorcontrib><creatorcontrib>HERENYI, B</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOÊROÊG, S</au><au>HERENYI, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>α 1-Acid glycoprotein column in the high-performance liquid chromatographic analysis of some groups of chiral drugs</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><date>1990</date><risdate>1990</risdate><volume>8</volume><issue>8</issue><spage>837</spage><epage>842</epage><pages>837-842</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>The usefulness of the α
1-acid glycoprotein (Chiral—AGP) column in the analysis of chiral drugs and related materials is illustrated in three different fields. Excellent separations of the enantiomers of pharmacologically active α-ethyl benzhydrols such as 3-trifluoromethyl-α-ethyl benzhydrol (flumecinol) and 11 other derivatives are described. The enantiomers of
N-protected amino-acid esters or amides can also be separated. The effect of the derivatization of the free α-amino group on the resolution of the enantiomers is exemplified by the formylation of alanine benzyl ester. As an example of the use of the method for the estimation of the optical purity of chiral drugs, the determination of the “
cis(−)” impurity in “
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| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1990, Vol.8 (8), p.837-842 |
| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_pascalfrancis_primary_19744827 |
| source | Elsevier ScienceDirect Journals |
| subjects | amino acid derivatives Analysis Biological and medical sciences chiral HPLC diltiazem enantiomeric separation General pharmacology Medical sciences Pharmacology. Drug treatments α 1-Acid glycoprotein α-ethyl benzhydrols |
| title | α 1-Acid glycoprotein column in the high-performance liquid chromatographic analysis of some groups of chiral drugs |
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