DNA Distribution Pattern in Chronic Gastritis: I. DNA Ploidy and Cell Cycle Distribution
DNA distribution patterns were flow cytometrically recorded in gastric biopsy specimens from patients with chronic gastritis (CG) and chronic atrophic gastritis (CAG). DNA aneuploidy was found in 3 of 58 patients with CG and in 7 of 82 patients with CAG. Cell cycle analysis disclosed significantly h...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1989, Vol.24 (6), p.643-648 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | Wetss, H. Gütz, H.-J. Schröter, J. Wildner, G.-P. |
| description | DNA distribution patterns were flow cytometrically recorded in gastric biopsy specimens from patients with chronic gastritis (CG) and chronic atrophic gastritis (CAG). DNA aneuploidy was found in 3 of 58 patients with CG and in 7 of 82 patients with CAG. Cell cycle analysis disclosed significantly higher percentages of cells in S-phase and G2M-phase, respectively, in CAG than in CG. With regard to the proliferative activity the total CAG group could be partially differentiated by the degree of severity. CAG with total atrophy showed significantly higher percentages of cells in S-phase than CAG with mild and moderate atrophy. CAG without dysplasia showed lower percentages of cells in S-phase and G2M-phase than CAG with severe dysplasia (p > 0.05). The occurrence of intestinal metaplasia was correlated to a significantly higher percentage of cells in G2M-phase. |
| doi_str_mv | 10.3109/00365528909093103 |
| format | Article |
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DNA Ploidy and Cell Cycle Distribution</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Access via Taylor & Francis</source><creator>Wetss, H. ; Gütz, H.-J. ; Schröter, J. ; Wildner, G.-P.</creator><creatorcontrib>Wetss, H. ; Gütz, H.-J. ; Schröter, J. ; Wildner, G.-P.</creatorcontrib><description>DNA distribution patterns were flow cytometrically recorded in gastric biopsy specimens from patients with chronic gastritis (CG) and chronic atrophic gastritis (CAG). DNA aneuploidy was found in 3 of 58 patients with CG and in 7 of 82 patients with CAG. Cell cycle analysis disclosed significantly higher percentages of cells in S-phase and G2M-phase, respectively, in CAG than in CG. With regard to the proliferative activity the total CAG group could be partially differentiated by the degree of severity. CAG with total atrophy showed significantly higher percentages of cells in S-phase than CAG with mild and moderate atrophy. CAG without dysplasia showed lower percentages of cells in S-phase and G2M-phase than CAG with severe dysplasia (p > 0.05). The occurrence of intestinal metaplasia was correlated to a significantly higher percentage of cells in G2M-phase.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365528909093103</identifier><identifier>PMID: 2814335</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adult ; Aged ; Atrophy ; Biological and medical sciences ; Cell Cycle ; Chronic atrophic gastritis ; Chronic Disease ; chronic gastritis ; DNA - analysis ; DNA distributions ; DNA ploidy ; Female ; Flow Cytometry ; Gastritis - metabolism ; Gastritis - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Intestines - pathology ; Male ; Medical sciences ; Metaplasia ; Middle Aged ; Other diseases. Semiology ; proliferative activity ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Scandinavian journal of gastroenterology, 1989, Vol.24 (6), p.643-648</ispartof><rights>1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1989</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-a46a207db731c2972d0c33d5364e648db2421148c281ba0655ba81cc005649863</citedby><cites>FETCH-LOGICAL-c441t-a46a207db731c2972d0c33d5364e648db2421148c281ba0655ba81cc005649863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365528909093103$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365528909093103$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19711234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2814335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wetss, H.</creatorcontrib><creatorcontrib>Gütz, H.-J.</creatorcontrib><creatorcontrib>Schröter, J.</creatorcontrib><creatorcontrib>Wildner, G.-P.</creatorcontrib><title>DNA Distribution Pattern in Chronic Gastritis: I. DNA Ploidy and Cell Cycle Distribution</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>DNA distribution patterns were flow cytometrically recorded in gastric biopsy specimens from patients with chronic gastritis (CG) and chronic atrophic gastritis (CAG). DNA aneuploidy was found in 3 of 58 patients with CG and in 7 of 82 patients with CAG. Cell cycle analysis disclosed significantly higher percentages of cells in S-phase and G2M-phase, respectively, in CAG than in CG. With regard to the proliferative activity the total CAG group could be partially differentiated by the degree of severity. CAG with total atrophy showed significantly higher percentages of cells in S-phase than CAG with mild and moderate atrophy. CAG without dysplasia showed lower percentages of cells in S-phase and G2M-phase than CAG with severe dysplasia (p > 0.05). The occurrence of intestinal metaplasia was correlated to a significantly higher percentage of cells in G2M-phase.</description><subject>Adult</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle</subject><subject>Chronic atrophic gastritis</subject><subject>Chronic Disease</subject><subject>chronic gastritis</subject><subject>DNA - analysis</subject><subject>DNA distributions</subject><subject>DNA ploidy</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Gastritis - metabolism</subject><subject>Gastritis - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Intestines - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metaplasia</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>proliferative activity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtqGzEUFaEhdR4f0EVBm2Y3qV4zmmmyCeM0NYQkixayG-5oZCwjS4mkIfjvI2M3xRSCFhd0HpxzEPpCyQWnpPlOCK_KktUNyS__8AM0oSVhhZSk_oQmG7zIBPoZHce4JISUUjRH6IjVVHBeTtDT9P4aT01MwfRjMt7hR0hJB4eNw-0ieGcUvoUNnkz8gWcXeKN4tN4MawxuwK22FrdrZfWezyk6nION-mx3T9Cfnze_21_F3cPtrL2-K5QQNBUgKmBEDr3kVLFGsoEozoeSV0JXoh56JhilolY5cQ8kt-2hpkrlJpVo6oqfoPOt73PwL6OOqVuZqHImcNqPsZN5FyEamYl0S1TBxxj0vHsOZgVh3VHSbdbs_lsza77uzMd-pYd3xW6-jH_b4RAV2HkAp0z8Z9xIShkXmXe15Rk392EFrz7YoUuwtj78FfGPYlzuyRcabFooCLpb-jG4vO8HJd4Abbueqw</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Wetss, H.</creator><creator>Gütz, H.-J.</creator><creator>Schröter, J.</creator><creator>Wildner, G.-P.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>DNA Distribution Pattern in Chronic Gastritis: I. DNA Ploidy and Cell Cycle Distribution</title><author>Wetss, H. ; Gütz, H.-J. ; Schröter, J. ; Wildner, G.-P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-a46a207db731c2972d0c33d5364e648db2421148c281ba0655ba81cc005649863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle</topic><topic>Chronic atrophic gastritis</topic><topic>Chronic Disease</topic><topic>chronic gastritis</topic><topic>DNA - analysis</topic><topic>DNA distributions</topic><topic>DNA ploidy</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Gastritis - metabolism</topic><topic>Gastritis - pathology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Intestines - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metaplasia</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>proliferative activity</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wetss, H.</creatorcontrib><creatorcontrib>Gütz, H.-J.</creatorcontrib><creatorcontrib>Schröter, J.</creatorcontrib><creatorcontrib>Wildner, G.-P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wetss, H.</au><au>Gütz, H.-J.</au><au>Schröter, J.</au><au>Wildner, G.-P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA Distribution Pattern in Chronic Gastritis: I. DNA Ploidy and Cell Cycle Distribution</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1989</date><risdate>1989</risdate><volume>24</volume><issue>6</issue><spage>643</spage><epage>648</epage><pages>643-648</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>DNA distribution patterns were flow cytometrically recorded in gastric biopsy specimens from patients with chronic gastritis (CG) and chronic atrophic gastritis (CAG). DNA aneuploidy was found in 3 of 58 patients with CG and in 7 of 82 patients with CAG. Cell cycle analysis disclosed significantly higher percentages of cells in S-phase and G2M-phase, respectively, in CAG than in CG. With regard to the proliferative activity the total CAG group could be partially differentiated by the degree of severity. CAG with total atrophy showed significantly higher percentages of cells in S-phase than CAG with mild and moderate atrophy. CAG without dysplasia showed lower percentages of cells in S-phase and G2M-phase than CAG with severe dysplasia (p > 0.05). The occurrence of intestinal metaplasia was correlated to a significantly higher percentage of cells in G2M-phase.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>2814335</pmid><doi>10.3109/00365528909093103</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0036-5521 |
| ispartof | Scandinavian journal of gastroenterology, 1989, Vol.24 (6), p.643-648 |
| issn | 0036-5521 1502-7708 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_19711234 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Adult Aged Atrophy Biological and medical sciences Cell Cycle Chronic atrophic gastritis Chronic Disease chronic gastritis DNA - analysis DNA distributions DNA ploidy Female Flow Cytometry Gastritis - metabolism Gastritis - pathology Gastroenterology. Liver. Pancreas. Abdomen Humans Intestines - pathology Male Medical sciences Metaplasia Middle Aged Other diseases. Semiology proliferative activity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | DNA Distribution Pattern in Chronic Gastritis: I. DNA Ploidy and Cell Cycle Distribution |
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