Effect of alanine insertion (P′5) on the reactive centre of α1‐antitrypsin

A recombinant mutant of α1‐antitrypsin with an inserted alanine in position P′1 (362=363) was compared with wild‐type recombinant and plasma α1‐antitrypsins. Initial studies showed that contrary to other reports the wild recombinant inhibitor had the same, or even greater, association constants with...

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Veröffentlicht in:	FEBS letters 1991-03, Vol.280 (1), p.41-43
Hauptverfasser:	Avron, Ann, Reeve, Francesca H., Lickorish, Josephine M., Carrell, Robin W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Serpin α1-Antitrypsin
Online-Zugang:	Volltext
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