NG-Methyl-L-Arginine Inhibits Tumor Necrosis Factor-Induced Hypotension: Implications for the Involvement of Nitric Oxide

Clinical assessment of the activity of tumor necrosis factor (TNF) against human cancer has been limited by a dose-dependent cardiovascular toxicity, most frequently hypotension. TNF is also thought to mediate the vascular collapse resulting from bacterial endotoxin. The present studies address the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-05, Vol.87 (9), p.3629-3632
Hauptverfasser:	Kilbourn, Robert G., Gross, Steven S., Jubran, Amal, Adams, James, Griffith, Owen W., Levi, Roberto, Lodato, Robert F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Blood pressure Blood Pressure - drug effects Dogs Drug toxicity and drugs side effects treatment Endothelial cells Endotoxins Heart rate Heart Rate - drug effects Hypotension Hypotension - chemically induced Laboratory animals Macrophages Medical sciences Nitric Oxide - metabolism omega-N-Methylarginine Oxides Pharmacology. Drug treatments Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - pharmacology Time Factors Toxicity: cardiovascular system Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factors Tumors
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