Involvement of Tyrosine Residues Located in the Carboxyl Tail of the Human β2-Adrenergic Receptor in Agonist-Induced Down-Regulation of the Receptor

Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell surface β2-adrenergic receptor (β2AR) number. Sequestration of the receptor away from the cell surface as well as a down-regulation of the total number of cellular receptors are believed to contribute to this a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-07, Vol.87 (13), p.5089-5093
Hauptverfasser:	Valiquette, Manon, Bonin, Hélène, Hnatowich, Mark, Caron, Marc G., Lefkowitz, Robert J., Bouvier, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Amino acids Biochemistry Biological and medical sciences Cell lines Cell membranes Cell receptors Cell structures and functions Cell surface receptors Down regulation Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Internalization Lead Molecular and cellular biology Receptors
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