The Effect of Faecal Enema on Five Microflora-Associated Characteristics in Patients with Antibiotic-Associated Diarrhoea
Patients with antibiotic-associated diarrhoea (AAD) show significant disturbances in short-chain fatty acid pattern. In the present study five more microflora-associated characteristics (MACs) were investigated before and after administration of an enema containing faecal microflora from a healthy p...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1999, Vol.34 (6), p.580-586 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | GUSTAFSSON, A BERSTAD, A LUND-TØNNESEN, S MIDTVEDT, T NORIN, E |
| description | Patients with antibiotic-associated diarrhoea (AAD) show significant disturbances in short-chain fatty acid pattern. In the present study five more microflora-associated characteristics (MACs) were investigated before and after administration of an enema containing faecal microflora from a healthy person on a Western diet.
The functions of the microflora were determined with gas chromatography, electrophoresis, and spectrophotometry.
The conversion of cholesterol to coprostanol and the concentration of urobilinogen and trypsin were significantly reduced in comparison with healthy persons. The pattern of mucin was altered, but beta-aspartylglycine remained the same as in healthy persons. Enema treatment influenced these functions to different extents.
Most MACs were significantly disturbed in patients with AAD. Administration of a human faecal enema modified these changes and relieved diarrhoea, usually within 4 days. |
| doi_str_mv | 10.1080/003655299750026038 |
| format | Article |
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The functions of the microflora were determined with gas chromatography, electrophoresis, and spectrophotometry.
The conversion of cholesterol to coprostanol and the concentration of urobilinogen and trypsin were significantly reduced in comparison with healthy persons. The pattern of mucin was altered, but beta-aspartylglycine remained the same as in healthy persons. Enema treatment influenced these functions to different extents.
Most MACs were significantly disturbed in patients with AAD. Administration of a human faecal enema modified these changes and relieved diarrhoea, usually within 4 days.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/003655299750026038</identifier><identifier>PMID: 10440607</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - adverse effects ; Bacteria - isolation & purification ; Bacteria - metabolism ; Biological and medical sciences ; Biological Therapy ; Cholestanol - analysis ; Cholestanol - biosynthesis ; Cholesterol - analysis ; Diarrhea - chemically induced ; Diarrhea - metabolism ; Diarrhea - therapy ; Dipeptides - analysis ; Drug toxicity and drugs side effects treatment ; Enema ; Feces - chemistry ; Feces - microbiology ; Female ; Humans ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Mucins - analysis ; Pharmacology. Drug treatments ; Toxicity: digestive system ; Trypsin - analysis ; Urobilinogen - analysis</subject><ispartof>Scandinavian journal of gastroenterology, 1999, Vol.34 (6), p.580-586</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-87c47e92d8a7878763ffc1c98fb9c19c06eb53f61de9a7764c7e12f28093e11b3</citedby><cites>FETCH-LOGICAL-c521t-87c47e92d8a7878763ffc1c98fb9c19c06eb53f61de9a7764c7e12f28093e11b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/003655299750026038$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/003655299750026038$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1937761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10440607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1944112$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>GUSTAFSSON, A</creatorcontrib><creatorcontrib>BERSTAD, A</creatorcontrib><creatorcontrib>LUND-TØNNESEN, S</creatorcontrib><creatorcontrib>MIDTVEDT, T</creatorcontrib><creatorcontrib>NORIN, E</creatorcontrib><title>The Effect of Faecal Enema on Five Microflora-Associated Characteristics in Patients with Antibiotic-Associated Diarrhoea</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Patients with antibiotic-associated diarrhoea (AAD) show significant disturbances in short-chain fatty acid pattern. In the present study five more microflora-associated characteristics (MACs) were investigated before and after administration of an enema containing faecal microflora from a healthy person on a Western diet.
The functions of the microflora were determined with gas chromatography, electrophoresis, and spectrophotometry.
The conversion of cholesterol to coprostanol and the concentration of urobilinogen and trypsin were significantly reduced in comparison with healthy persons. The pattern of mucin was altered, but beta-aspartylglycine remained the same as in healthy persons. Enema treatment influenced these functions to different extents.
Most MACs were significantly disturbed in patients with AAD. Administration of a human faecal enema modified these changes and relieved diarrhoea, usually within 4 days.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Bacteria - isolation & purification</subject><subject>Bacteria - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biological Therapy</subject><subject>Cholestanol - analysis</subject><subject>Cholestanol - biosynthesis</subject><subject>Cholesterol - analysis</subject><subject>Diarrhea - chemically induced</subject><subject>Diarrhea - metabolism</subject><subject>Diarrhea - therapy</subject><subject>Dipeptides - analysis</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Enema</subject><subject>Feces - chemistry</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Mucins - analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: digestive system</subject><subject>Trypsin - analysis</subject><subject>Urobilinogen - analysis</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EokvhD3BAPnANjPPlWILDatkFpKL2UM7RxBkrLtl4Zbtd7b_HVba0qGrlgy37eUYzfhl7L-CTgAY-AxR1VeVKyQogr6FoXrCFqCDPpITmJVvcAlkixAl7E8IVAFSyVK_ZiYCyhBrkgh0uB-JrY0hH7gzfIGkc-XqiLXI38Y29If7Lau_M6DxmyxCcthip56sBPepI3oZodeB24hcYLU0x8L2NA19O0XbWpceH2jeL3g-O8C17ZXAM9O64n7Lfm_Xl6kd2dv7952p5lunUeMwaqUtJKu8blE1adWGMFlo1plNaKA01dVVhatGTQinrUksSuckbUAUJ0RWnLJvrhj3trrt25-0W_aF1aNvj1Z90oraGsq4g8fJJfuddfy_diUKVpRB5MvPZTN8VgifzzxXQ3ibWPk4sSR9mKdXcUv9AmSNKwMcjgCFlYzxO2oZ7ThVpapGwrzNmJ-P8FvfOj30b8ZByu3OKZ_v48p8_EI5x0OipvXLXfkoRPTfGX6dzxdM</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>GUSTAFSSON, A</creator><creator>BERSTAD, A</creator><creator>LUND-TØNNESEN, S</creator><creator>MIDTVEDT, T</creator><creator>NORIN, E</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>1999</creationdate><title>The Effect of Faecal Enema on Five Microflora-Associated Characteristics in Patients with Antibiotic-Associated Diarrhoea</title><author>GUSTAFSSON, A ; BERSTAD, A ; LUND-TØNNESEN, S ; MIDTVEDT, T ; NORIN, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-87c47e92d8a7878763ffc1c98fb9c19c06eb53f61de9a7764c7e12f28093e11b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Bacteria - isolation & purification</topic><topic>Bacteria - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biological Therapy</topic><topic>Cholestanol - analysis</topic><topic>Cholestanol - biosynthesis</topic><topic>Cholesterol - analysis</topic><topic>Diarrhea - chemically induced</topic><topic>Diarrhea - metabolism</topic><topic>Diarrhea - therapy</topic><topic>Dipeptides - analysis</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Enema</topic><topic>Feces - chemistry</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Mucins - analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: digestive system</topic><topic>Trypsin - analysis</topic><topic>Urobilinogen - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GUSTAFSSON, A</creatorcontrib><creatorcontrib>BERSTAD, A</creatorcontrib><creatorcontrib>LUND-TØNNESEN, S</creatorcontrib><creatorcontrib>MIDTVEDT, T</creatorcontrib><creatorcontrib>NORIN, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GUSTAFSSON, A</au><au>BERSTAD, A</au><au>LUND-TØNNESEN, S</au><au>MIDTVEDT, T</au><au>NORIN, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Faecal Enema on Five Microflora-Associated Characteristics in Patients with Antibiotic-Associated Diarrhoea</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1999</date><risdate>1999</risdate><volume>34</volume><issue>6</issue><spage>580</spage><epage>586</epage><pages>580-586</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Patients with antibiotic-associated diarrhoea (AAD) show significant disturbances in short-chain fatty acid pattern. In the present study five more microflora-associated characteristics (MACs) were investigated before and after administration of an enema containing faecal microflora from a healthy person on a Western diet.
The functions of the microflora were determined with gas chromatography, electrophoresis, and spectrophotometry.
The conversion of cholesterol to coprostanol and the concentration of urobilinogen and trypsin were significantly reduced in comparison with healthy persons. The pattern of mucin was altered, but beta-aspartylglycine remained the same as in healthy persons. Enema treatment influenced these functions to different extents.
Most MACs were significantly disturbed in patients with AAD. Administration of a human faecal enema modified these changes and relieved diarrhoea, usually within 4 days.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>10440607</pmid><doi>10.1080/003655299750026038</doi><tpages>7</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1999, Vol.34 (6), p.580-586 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Adult Aged Aged, 80 and over Anti-Bacterial Agents - adverse effects Bacteria - isolation & purification Bacteria - metabolism Biological and medical sciences Biological Therapy Cholestanol - analysis Cholestanol - biosynthesis Cholesterol - analysis Diarrhea - chemically induced Diarrhea - metabolism Diarrhea - therapy Dipeptides - analysis Drug toxicity and drugs side effects treatment Enema Feces - chemistry Feces - microbiology Female Humans Male Medical sciences Medicin och hälsovetenskap Middle Aged Mucins - analysis Pharmacology. Drug treatments Toxicity: digestive system Trypsin - analysis Urobilinogen - analysis |
| title | The Effect of Faecal Enema on Five Microflora-Associated Characteristics in Patients with Antibiotic-Associated Diarrhoea |
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