Biodistribution of A Novel Antiestrogen (Analog II) in the Mouse and Rat
The biostribution of a novel antiestrogen Analog II was determined in the mouse and rat. The tritiated product, [3H]-Analog II was prepared by New England Nuclear and was purified by preparative chromatography using silica gel and petroleum ether/methylene chloride (80:20). The fat tissue had the hi...
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| Veröffentlicht in: | Endocrine research 1990, Vol.16 (2), p.269-282 |
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| container_end_page | 282 |
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| container_issue | 2 |
| container_start_page | 269 |
| container_title | Endocrine research |
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| creator | Griffin, M. T. Pento, J. T. Magarian, R. A. Mousissian, G. K. Basmadjian, G. P. |
| description | The biostribution of a novel antiestrogen Analog II was determined in the mouse and rat. The tritiated product, [3H]-Analog II was prepared by New England Nuclear and was purified by preparative chromatography using silica gel and petroleum ether/methylene chloride (80:20). The fat tissue had the highest uptake due to the hydrophobic nature of Analog II. The second highest uptake was in the mouse uterine tissue which was greater than that observed in the rat. The differences in biodistribution between the mouse and rat may partially explain the differences in biological activity of Analog II previously observed in these two animal species. |
| doi_str_mv | 10.1080/07435809009033005 |
| format | Article |
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T. ; Pento, J. T. ; Magarian, R. A. ; Mousissian, G. K. ; Basmadjian, G. P.</creator><creatorcontrib>Griffin, M. T. ; Pento, J. T. ; Magarian, R. A. ; Mousissian, G. K. ; Basmadjian, G. P.</creatorcontrib><description>The biostribution of a novel antiestrogen Analog II was determined in the mouse and rat. The tritiated product, [3H]-Analog II was prepared by New England Nuclear and was purified by preparative chromatography using silica gel and petroleum ether/methylene chloride (80:20). The fat tissue had the highest uptake due to the hydrophobic nature of Analog II. The second highest uptake was in the mouse uterine tissue which was greater than that observed in the rat. The differences in biodistribution between the mouse and rat may partially explain the differences in biological activity of Analog II previously observed in these two animal species.</description><identifier>ISSN: 0743-5800</identifier><identifier>EISSN: 1532-4206</identifier><identifier>DOI: 10.1080/07435809009033005</identifier><identifier>PMID: 2344839</identifier><identifier>CODEN: ENRSE8</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Adipose Tissue - metabolism ; Animals ; Biological and medical sciences ; Brain - metabolism ; Estrogen Antagonists - pharmacology ; Female ; Genital system. Reproduction ; Half-Life ; Kidney - metabolism ; Kinetics ; Liver - metabolism ; Medical sciences ; Mice ; Muscles - metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Tamoxifen - analogs & derivatives ; Tamoxifen - chemical synthesis ; Tamoxifen - isolation & purification ; Tamoxifen - pharmacology ; Tissue Distribution ; Uterus - metabolism</subject><ispartof>Endocrine research, 1990, Vol.16 (2), p.269-282</ispartof><rights>1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-553e054ddfc614cb279504cc6e7fa08debe91e26a06116fbc2065be4079d14073</citedby><cites>FETCH-LOGICAL-c431t-553e054ddfc614cb279504cc6e7fa08debe91e26a06116fbc2065be4079d14073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/07435809009033005$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/07435809009033005$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19340563$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2344839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Griffin, M. T.</creatorcontrib><creatorcontrib>Pento, J. T.</creatorcontrib><creatorcontrib>Magarian, R. A.</creatorcontrib><creatorcontrib>Mousissian, G. K.</creatorcontrib><creatorcontrib>Basmadjian, G. P.</creatorcontrib><title>Biodistribution of A Novel Antiestrogen (Analog II) in the Mouse and Rat</title><title>Endocrine research</title><addtitle>Endocr Res</addtitle><description>The biostribution of a novel antiestrogen Analog II was determined in the mouse and rat. The tritiated product, [3H]-Analog II was prepared by New England Nuclear and was purified by preparative chromatography using silica gel and petroleum ether/methylene chloride (80:20). The fat tissue had the highest uptake due to the hydrophobic nature of Analog II. The second highest uptake was in the mouse uterine tissue which was greater than that observed in the rat. The differences in biodistribution between the mouse and rat may partially explain the differences in biological activity of Analog II previously observed in these two animal species.</description><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Estrogen Antagonists - pharmacology</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Half-Life</subject><subject>Kidney - metabolism</subject><subject>Kinetics</subject><subject>Liver - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Muscles - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tamoxifen - analogs & derivatives</subject><subject>Tamoxifen - chemical synthesis</subject><subject>Tamoxifen - isolation & purification</subject><subject>Tamoxifen - pharmacology</subject><subject>Tissue Distribution</subject><subject>Uterus - metabolism</subject><issn>0743-5800</issn><issn>1532-4206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtrGzEUhUVpcJ3HD8iioE1DupjkaiTNeGg2rsnDkKRQkvWg0dyJFWQplWZa_O8jYyclBAJCWpzvHM69IuSQwQmDCZxCKbicQAXpcA4gP5ExkzzPRA7FZzJe61kC4AvZjfERgCWIj8go50JMeDUmVz-Nb03sg2mG3nhHfUen9Nb_RUunrjeYJP-Ajh5PnbL-gc7n36lxtF8gvfFDRKpcS3-rfp_sdMpGPNi-e-T-4vxudpVd_7qcz6bXmRac9ZmUHEGKtu10wYRu8rKSILQusOwUTFpssGKYFwoKxoqu0WkQ2aCAsmpZuvkeOdrkPgX_Z0j16qWJGq1VDlOfuqxSYpHLBLINqIOPMWBXPwWzVGFVM6jX26vfbS95vm7Dh2aJ7atju66kf9vqKmplu6CcNvF_cMUFyIIn7mzDGdf5sFT_fLBt3auV9eHFxD-q8eONfYHK9gutAtaPfgjpI-IHQzwDOJSZ0w</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Griffin, M. T.</creator><creator>Pento, J. T.</creator><creator>Magarian, R. A.</creator><creator>Mousissian, G. K.</creator><creator>Basmadjian, G. P.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Biodistribution of A Novel Antiestrogen (Analog II) in the Mouse and Rat</title><author>Griffin, M. T. ; Pento, J. T. ; Magarian, R. A. ; Mousissian, G. K. ; Basmadjian, G. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-553e054ddfc614cb279504cc6e7fa08debe91e26a06116fbc2065be4079d14073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Estrogen Antagonists - pharmacology</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>Half-Life</topic><topic>Kidney - metabolism</topic><topic>Kinetics</topic><topic>Liver - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Muscles - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tamoxifen - analogs & derivatives</topic><topic>Tamoxifen - chemical synthesis</topic><topic>Tamoxifen - isolation & purification</topic><topic>Tamoxifen - pharmacology</topic><topic>Tissue Distribution</topic><topic>Uterus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Griffin, M. T.</creatorcontrib><creatorcontrib>Pento, J. T.</creatorcontrib><creatorcontrib>Magarian, R. A.</creatorcontrib><creatorcontrib>Mousissian, G. K.</creatorcontrib><creatorcontrib>Basmadjian, G. 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P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biodistribution of A Novel Antiestrogen (Analog II) in the Mouse and Rat</atitle><jtitle>Endocrine research</jtitle><addtitle>Endocr Res</addtitle><date>1990</date><risdate>1990</risdate><volume>16</volume><issue>2</issue><spage>269</spage><epage>282</epage><pages>269-282</pages><issn>0743-5800</issn><eissn>1532-4206</eissn><coden>ENRSE8</coden><abstract>The biostribution of a novel antiestrogen Analog II was determined in the mouse and rat. The tritiated product, [3H]-Analog II was prepared by New England Nuclear and was purified by preparative chromatography using silica gel and petroleum ether/methylene chloride (80:20). The fat tissue had the highest uptake due to the hydrophobic nature of Analog II. The second highest uptake was in the mouse uterine tissue which was greater than that observed in the rat. The differences in biodistribution between the mouse and rat may partially explain the differences in biological activity of Analog II previously observed in these two animal species.</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>2344839</pmid><doi>10.1080/07435809009033005</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-5800 |
| ispartof | Endocrine research, 1990, Vol.16 (2), p.269-282 |
| issn | 0743-5800 1532-4206 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adipose Tissue - metabolism Animals Biological and medical sciences Brain - metabolism Estrogen Antagonists - pharmacology Female Genital system. Reproduction Half-Life Kidney - metabolism Kinetics Liver - metabolism Medical sciences Mice Muscles - metabolism Pharmacology. Drug treatments Rats Rats, Inbred Strains Tamoxifen - analogs & derivatives Tamoxifen - chemical synthesis Tamoxifen - isolation & purification Tamoxifen - pharmacology Tissue Distribution Uterus - metabolism |
| title | Biodistribution of A Novel Antiestrogen (Analog II) in the Mouse and Rat |
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