Three-Dimensional Structures of Influenza Virus Neuraminidase-Antibody Complexes

X-ray diffraction analysis of crystals of a monoclonal Fab fragment NC41 bound to a viral antigen, influenza virus neuraminidase, shows an epitope involving five surface loops of the antigen. In addition it reveals an unusual pairing pattern between the domains of light and heavy chains in the varia...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B, Biological sciences Biological sciences, 1989-06, Vol.323 (1217), p.511-518
Hauptverfasser:	Colman, P. M., Tulip, W. R., Varghese, J. N., Tulloch, P. A., Baker, A. T., Laver, W. G., Air, G. M., Webster, R. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibodies Antigen-Antibody Complex Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation Antigens Biological and medical sciences Crystals Electron density Epitopes Fundamental and applied biological sciences. Psychology Fundamental immunology Immunoglobulin Fab Fragments Immunoglobulins Macromolecular Substances Models, Molecular Molecular immunology Neuraminidase - immunology Orthomyxoviridae Orthomyxoviridae - enzymology Protein Conformation Viral morphology Viruses X-Ray Diffraction
Online-Zugang:	Volltext
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