Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity

The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2toxicity in Drosophila is examined through the properties of a mutant strain carrying a cSOD-null mutation, cSODn108. Homozygotes are viable as larvae, whi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-04, Vol.86 (8), p.2761-2765
Hauptverfasser:	Phillips, J.P, Campbell, S.D, Michaud, D, Charbonneau, M, Hilliker, A.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cations, Monovalent Chromosomes CINC COBRE COPPER Copper - toxicity CUIVRE DROSOPHILA DROSOPHILA MELANOGASTER Drosophila melanogaster - drug effects Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophilidae Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Genetic mutation HERBICIDAS HERBICIDE HERBICIDES HIPERSENSIBILIDAD HYPERSENSIBILITE HYPERSENSITIVITY Infertility, Female - genetics Infertility, Male - genetics Insect larvae Larvae Larval development Life Expectancy LONGEVIDAD LONGEVITE LONGEVITY Male Metabolism MUTACION MUTATION OXIDOREDUCTASES OXIDORREDUCTASAS OXYDOREDUCTASE Paraquat - toxicity Reactive oxygen species SUPEROXIDE DISMUTASE Superoxide Dismutase - physiology Superoxides Superoxides - metabolism SUPEROXIDO DISMUTASA SUPEROXYDE DISMUTASE TOXICIDAD TOXICITE TOXICITY ZINC
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