Drug Release from Ammonio-Methacrylate-Coated Diltiazem Particles: Influence of the Reservoir on Membrane Behavior
Drug-layered sugar spheres 15, 45, and 64% potent were made such that each had the same particle size distribution. The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal releas...
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| Veröffentlicht in: | Pharmaceutical development and technology 2007-01, Vol.12 (5), p.473-479 |
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| container_title | Pharmaceutical development and technology |
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| creator | Heinicke, Grant Schwartz, Joseph B. |
| description | Drug-layered sugar spheres 15, 45, and 64% potent were made such that each had the same particle size distribution. The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal release pattern, where a lag time was followed by relatively rapid drug release. Lag time depended on the applied polymer amount, the media used, and the sugar content, where an increase in sugar content caused greater expansion before drug release. Lag times were related to expansion. Expansion of coated sugar spheres was measured. |
| doi_str_mv | 10.1080/10837450701557089 |
| format | Article |
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The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal release pattern, where a lag time was followed by relatively rapid drug release. Lag time depended on the applied polymer amount, the media used, and the sugar content, where an increase in sugar content caused greater expansion before drug release. Lag times were related to expansion. 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Drug treatments ; polymethacrylate ; Polymethacrylic Acids - chemistry ; Quaternary Ammonium Compounds - chemistry ; Vasodilator Agents - administration & dosage ; Vasodilator Agents - chemistry ; Vasodilator Agents - pharmacokinetics</subject><ispartof>Pharmaceutical development and technology, 2007-01, Vol.12 (5), p.473-479</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-87eda8b701f6d3f6caf364823999da9f876fa256457aa324450d6d42f0155e7a3</citedby><cites>FETCH-LOGICAL-c434t-87eda8b701f6d3f6caf364823999da9f876fa256457aa324450d6d42f0155e7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10837450701557089$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10837450701557089$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,59652,59758,60441,60547,61226,61261,61407,61442</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19237846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17963147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heinicke, Grant</creatorcontrib><creatorcontrib>Schwartz, Joseph B.</creatorcontrib><title>Drug Release from Ammonio-Methacrylate-Coated Diltiazem Particles: Influence of the Reservoir on Membrane Behavior</title><title>Pharmaceutical development and technology</title><addtitle>Pharm Dev Technol</addtitle><description>Drug-layered sugar spheres 15, 45, and 64% potent were made such that each had the same particle size distribution. The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal release pattern, where a lag time was followed by relatively rapid drug release. Lag time depended on the applied polymer amount, the media used, and the sugar content, where an increase in sugar content caused greater expansion before drug release. Lag times were related to expansion. Expansion of coated sugar spheres was measured.</description><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Buffers</subject><subject>Carbohydrates - chemistry</subject><subject>Cellulose - chemistry</subject><subject>Delayed-Action Preparations</subject><subject>Diltiazem - administration & dosage</subject><subject>Diltiazem - chemistry</subject><subject>Diltiazem - pharmacokinetics</subject><subject>drug release</subject><subject>Excipients - chemistry</subject><subject>General pharmacology</subject><subject>Hydrochloric Acid - chemistry</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>osmotic pressure</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>polymethacrylate</subject><subject>Polymethacrylic Acids - chemistry</subject><subject>Quaternary Ammonium Compounds - chemistry</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Vasodilator Agents - chemistry</subject><subject>Vasodilator Agents - pharmacokinetics</subject><issn>1083-7450</issn><issn>1097-9867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhiMEoqXwA7ggX-AWcGLHH8ClbPmo1AqE4BzNOmPWlROXcVK0_Hq82kUVQupl7MPzjuZ9quppw1823PBXZQgtO65503WaG3uvOm641bU1St_f_Y2od8BR9SjnK84bY3n3sDpqtFWikfq4ojNafrCvGBEyMk9pZKfjmKaQ6kucN-BoG2HGepXKHNhZiHOA3ziyL0BzcBHza3Y--bjg5JAlz-YNlnUZ6SYFYmlilziuCSZk73ADNyHR4-qBh5jxyeE9qb5_eP9t9am--PzxfHV6UTsp5FwbjQOYdenm1SC8cuCFkqYV1toBrDdaeWg7JTsNIFpZag5qkK3fyUAN4qR6sd97Tenngnnux5AdxliOSUvulZGyLYYK2OxBRylnQt9fUxiBtn3D-53o_j_RJfPssHxZjzjcJg5mC_D8AEB2EH1R4EK-5WwrtJGqcG_3XJh8ohF-JYpDP8M2JvobEnfd8eaf-AYhzhsHhP1VWmgqgu9o8QdtiatB</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Heinicke, Grant</creator><creator>Schwartz, Joseph B.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Informa Healthcare</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Drug Release from Ammonio-Methacrylate-Coated Diltiazem Particles: Influence of the Reservoir on Membrane Behavior</title><author>Heinicke, Grant ; Schwartz, Joseph B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-87eda8b701f6d3f6caf364823999da9f876fa256457aa324450d6d42f0155e7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Buffers</topic><topic>Carbohydrates - chemistry</topic><topic>Cellulose - chemistry</topic><topic>Delayed-Action Preparations</topic><topic>Diltiazem - administration & dosage</topic><topic>Diltiazem - chemistry</topic><topic>Diltiazem - pharmacokinetics</topic><topic>drug release</topic><topic>Excipients - chemistry</topic><topic>General pharmacology</topic><topic>Hydrochloric Acid - chemistry</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>osmotic pressure</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>polymethacrylate</topic><topic>Polymethacrylic Acids - chemistry</topic><topic>Quaternary Ammonium Compounds - chemistry</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Vasodilator Agents - chemistry</topic><topic>Vasodilator Agents - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heinicke, Grant</creatorcontrib><creatorcontrib>Schwartz, Joseph B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical development and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heinicke, Grant</au><au>Schwartz, Joseph B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug Release from Ammonio-Methacrylate-Coated Diltiazem Particles: Influence of the Reservoir on Membrane Behavior</atitle><jtitle>Pharmaceutical development and technology</jtitle><addtitle>Pharm Dev Technol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>12</volume><issue>5</issue><spage>473</spage><epage>479</epage><pages>473-479</pages><issn>1083-7450</issn><eissn>1097-9867</eissn><abstract>Drug-layered sugar spheres 15, 45, and 64% potent were made such that each had the same particle size distribution. The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal release pattern, where a lag time was followed by relatively rapid drug release. Lag time depended on the applied polymer amount, the media used, and the sugar content, where an increase in sugar content caused greater expansion before drug release. Lag times were related to expansion. Expansion of coated sugar spheres was measured.</abstract><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>17963147</pmid><doi>10.1080/10837450701557089</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-7450 |
| ispartof | Pharmaceutical development and technology, 2007-01, Vol.12 (5), p.473-479 |
| issn | 1083-7450 1097-9867 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_19237846 |
| source | MEDLINE; EBSCOhost Business Source Complete; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Biological and medical sciences Biological Availability Buffers Carbohydrates - chemistry Cellulose - chemistry Delayed-Action Preparations Diltiazem - administration & dosage Diltiazem - chemistry Diltiazem - pharmacokinetics drug release Excipients - chemistry General pharmacology Hydrochloric Acid - chemistry Medical sciences Microscopy, Electron, Scanning osmotic pressure Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments polymethacrylate Polymethacrylic Acids - chemistry Quaternary Ammonium Compounds - chemistry Vasodilator Agents - administration & dosage Vasodilator Agents - chemistry Vasodilator Agents - pharmacokinetics |
| title | Drug Release from Ammonio-Methacrylate-Coated Diltiazem Particles: Influence of the Reservoir on Membrane Behavior |
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