Pharmaceutical Applications of Hot-Melt Extrusion: Part II
The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including...
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| Veröffentlicht in: | Drug development and industrial pharmacy 2007-01, Vol.33 (10), p.1043-1057 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Repka, Michael A. Battu, Sunil Kumar Upadhye, Sampada B. Thumma, Sridhar Crowley, Michael M. Zhang, Feng Martin, Charles McGinity, James W. |
| description | The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in hot-melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of hot-melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems. |
| doi_str_mv | 10.1080/03639040701525627 |
| format | Article |
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Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in hot-melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of hot-melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1080/03639040701525627</identifier><identifier>PMID: 17963112</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>bioavailability ; Biological and medical sciences ; Capsules ; Delayed-Action Preparations ; Dosage Forms ; Drug Compounding - instrumentation ; Drug Compounding - methods ; drug delivery systems ; General pharmacology ; hot-melt extrusion ; Humans ; Medical sciences ; melt extruded films ; melt-extruded tablets ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in hot-melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of hot-melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.</description><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Capsules</subject><subject>Delayed-Action Preparations</subject><subject>Dosage Forms</subject><subject>Drug Compounding - instrumentation</subject><subject>Drug Compounding - methods</subject><subject>drug delivery systems</subject><subject>General pharmacology</subject><subject>hot-melt extrusion</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>melt extruded films</subject><subject>melt-extruded tablets</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Quality Control</subject><subject>solid dispersion</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical - instrumentation</subject><subject>Technology, Pharmaceutical - methods</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEURoMoWqsP4EZmo7vR_KepbkTUFiq6cD_cphk6kk5qkkF9e1NaKSJ0lY_kfJebg9AZwVcED_A1ZpJpzLHCRFAhqdpDvZxwKZSk-6i3ei8zII7QcYzvGBOqhThER0RpyQihPTR8nUNYgLFdagy44m65dDmkxrex8HUx8ql8ti4VD18pdDFfD4tXCKkYj0_QQQ0u2tPN2Udvjw9v96Ny8vI0vr-blEZglkrQajClFiAHboUQNbCpVmoATDOpjeWG12zGaq5mHCTXUlgxNZpLq4SUrI8u12OXwX90NqZq0URjnYPW-i5WcsAZF1JnkKxBE3yMwdbVMjQLCN8VwdXKV_XPV-6cb4Z304WdbRsbQRm42AAQs586QGuauOU0pZSzFXe75pq29lnopw9uViX4dj78ltiuPW7-1OcWXJobCLZ6911os98dv_gBjCuV_A</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Repka, Michael A.</creator><creator>Battu, Sunil Kumar</creator><creator>Upadhye, Sampada B.</creator><creator>Thumma, Sridhar</creator><creator>Crowley, Michael M.</creator><creator>Zhang, Feng</creator><creator>Martin, Charles</creator><creator>McGinity, James W.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Pharmaceutical Applications of Hot-Melt Extrusion: Part II</title><author>Repka, Michael A. ; Battu, Sunil Kumar ; Upadhye, Sampada B. ; Thumma, Sridhar ; Crowley, Michael M. ; Zhang, Feng ; Martin, Charles ; McGinity, James W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-a978b2eaaa974e555fa3b9778a39369ce4c4f3d3f47d4a64965e5bc946e75663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Capsules</topic><topic>Delayed-Action Preparations</topic><topic>Dosage Forms</topic><topic>Drug Compounding - instrumentation</topic><topic>Drug Compounding - methods</topic><topic>drug delivery systems</topic><topic>General pharmacology</topic><topic>hot-melt extrusion</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>melt extruded films</topic><topic>melt-extruded tablets</topic><topic>Pharmaceutical technology. 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Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in hot-melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. 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| source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN; EBSCOhost Business Source Complete |
| subjects | bioavailability Biological and medical sciences Capsules Delayed-Action Preparations Dosage Forms Drug Compounding - instrumentation Drug Compounding - methods drug delivery systems General pharmacology hot-melt extrusion Humans Medical sciences melt extruded films melt-extruded tablets Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Quality Control solid dispersion Tablets Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods |
| title | Pharmaceutical Applications of Hot-Melt Extrusion: Part II |
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