Effect of oral ZnDTPA on late effects of injected plutonium in rat
Purpose: To reduce the long-term toxicity of 239Pu in rats by lifetime drinking of ZnDTPA solution and to investigate possible side-effects of the drug. Materials and methods: Male Sprague-Dawley rats received a single injection of 239Pu citrate, alone or plus oral ZnDTPA. Additional groups were adm...
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Veröffentlicht in: | International journal of radiation biology 1999, Vol.75 (8), p.929-941 |
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description | Purpose: To reduce the long-term toxicity of 239Pu in rats by lifetime drinking of ZnDTPA solution and to investigate possible side-effects of the drug. Materials and methods: Male Sprague-Dawley rats received a single injection of 239Pu citrate, alone or plus oral ZnDTPA. Additional groups were administered only ZnDTPA. Late tissue changes were evaluated by post-mortem examination, X-rays and histologically. Results: The incidence of rat bearing osteosarcoma decreased after treatment to 35% as compared with 53% in untreated controls. The proportional incidence of osteosarcomas was reduced after ZnDTPA by more than the corresponding removal of 239Pu. Unexpectedly in the male rat, mammary tumours, mostly malignant, developed in 20% of rats that received 239Pu as compared with 0.5% in the untreated controls. After a lifetime drinking solely 3x10-3 m ZnDTPA the incidence of diffuse glomerulosclerosis reached 29% as compared with 10% in controls. Conclusions: In rat, protracted oral administration of ZnDTPA reduced the incidence of osteosarcomas after injection of 239Pu, even if treatment started with a delay of 1 month. In the latter case, however, more soft tissue damage was found than after treatment beginning at 4 days post-239Pu. An increased incidence of diffuse glomerulosclerosis was observed as a side effect of oral ZnDTPA only when given continuously, alone and in high amounts. |
doi_str_mv | 10.1080/095530099139692 |
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LUZ, E. SCHAFFER, W. A. MULLER, J. RENCOVA, V.</creator><creatorcontrib>VOLF, A. LUZ, E. SCHAFFER, W. A. MULLER, J. RENCOVA, V.</creatorcontrib><description>Purpose: To reduce the long-term toxicity of 239Pu in rats by lifetime drinking of ZnDTPA solution and to investigate possible side-effects of the drug. Materials and methods: Male Sprague-Dawley rats received a single injection of 239Pu citrate, alone or plus oral ZnDTPA. Additional groups were administered only ZnDTPA. Late tissue changes were evaluated by post-mortem examination, X-rays and histologically. Results: The incidence of rat bearing osteosarcoma decreased after treatment to 35% as compared with 53% in untreated controls. The proportional incidence of osteosarcomas was reduced after ZnDTPA by more than the corresponding removal of 239Pu. Unexpectedly in the male rat, mammary tumours, mostly malignant, developed in 20% of rats that received 239Pu as compared with 0.5% in the untreated controls. After a lifetime drinking solely 3x10-3 m ZnDTPA the incidence of diffuse glomerulosclerosis reached 29% as compared with 10% in controls. Conclusions: In rat, protracted oral administration of ZnDTPA reduced the incidence of osteosarcomas after injection of 239Pu, even if treatment started with a delay of 1 month. In the latter case, however, more soft tissue damage was found than after treatment beginning at 4 days post-239Pu. An increased incidence of diffuse glomerulosclerosis was observed as a side effect of oral ZnDTPA only when given continuously, alone and in high amounts.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/095530099139692</identifier><identifier>PMID: 10465359</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Biological effects of radiation ; Bone and Bones - drug effects ; Bone and Bones - radiation effects ; Bone Neoplasms - prevention & control ; Fundamental and applied biological sciences. Psychology ; Glomerulosclerosis, Focal Segmental - chemically induced ; Male ; Mammary Neoplasms, Experimental - prevention & control ; Miscellaneous ; Osteosarcoma - prevention & control ; Pentetic Acid - pharmacology ; Pentetic Acid - toxicity ; Plutonium - pharmacokinetics ; Plutonium - toxicity ; Radiometry ; Rats ; Rats, Sprague-Dawley ; Survival Rate ; Time Factors ; Tissue Distribution - drug effects ; Tissues, organs and organisms biophysics</subject><ispartof>International journal of radiation biology, 1999, Vol.75 (8), p.929-941</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-379f6aeddfdbf2f7e71df795243d3bed0d9ab900e7583a59014fa0e92e548cbe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/095530099139692$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/095530099139692$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1913719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10465359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VOLF, A. LUZ, E. SCHAFFER, W. A. MULLER, J. RENCOVA, V.</creatorcontrib><title>Effect of oral ZnDTPA on late effects of injected plutonium in rat</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>Purpose: To reduce the long-term toxicity of 239Pu in rats by lifetime drinking of ZnDTPA solution and to investigate possible side-effects of the drug. Materials and methods: Male Sprague-Dawley rats received a single injection of 239Pu citrate, alone or plus oral ZnDTPA. Additional groups were administered only ZnDTPA. Late tissue changes were evaluated by post-mortem examination, X-rays and histologically. Results: The incidence of rat bearing osteosarcoma decreased after treatment to 35% as compared with 53% in untreated controls. The proportional incidence of osteosarcomas was reduced after ZnDTPA by more than the corresponding removal of 239Pu. Unexpectedly in the male rat, mammary tumours, mostly malignant, developed in 20% of rats that received 239Pu as compared with 0.5% in the untreated controls. After a lifetime drinking solely 3x10-3 m ZnDTPA the incidence of diffuse glomerulosclerosis reached 29% as compared with 10% in controls. Conclusions: In rat, protracted oral administration of ZnDTPA reduced the incidence of osteosarcomas after injection of 239Pu, even if treatment started with a delay of 1 month. In the latter case, however, more soft tissue damage was found than after treatment beginning at 4 days post-239Pu. An increased incidence of diffuse glomerulosclerosis was observed as a side effect of oral ZnDTPA only when given continuously, alone and in high amounts.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - radiation effects</subject><subject>Bone Neoplasms - prevention & control</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glomerulosclerosis, Focal Segmental - chemically induced</subject><subject>Male</subject><subject>Mammary Neoplasms, Experimental - prevention & control</subject><subject>Miscellaneous</subject><subject>Osteosarcoma - prevention & control</subject><subject>Pentetic Acid - pharmacology</subject><subject>Pentetic Acid - toxicity</subject><subject>Plutonium - pharmacokinetics</subject><subject>Plutonium - toxicity</subject><subject>Radiometry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Tissue Distribution - drug effects</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EoqUwsyEPrKF2nJfZSikPqRIMZWGJnPhaTeXElZ0I9d_jkCIeUicf3fOdK9-D0CUlN5RkZEp4HDNCOKeMJzw8QmPKkjBgfn6Mxr3rNQlH6My5DfGKsOwUjSiJkpjFfIzuFkpB2WKjsLFC4_fmfvU6w6bBWrSA4ct1vV01Gy9B4q3uWtNUXe1H2Ir2HJ0ooR1c7N8JentYrOZPwfLl8Xk-WwZlFLI2YClXiQAplSxUqFJIqVQpj8OISVaAJJKLghMCaZwxEXNCIyUI8BDiKCsLYBM0HfaW1jhnQeVbW9XC7nJK8r6N_F8bPnE1JLZdUYP8xQ_ne-B6DwhXCq2saMrK_XB-UUp77HbAqkYZW4sPY7XMW7HTxn5n2OFP8D_hNQjdrkthId-Yzja-soMHfAIcRIq3</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>VOLF, A. LUZ, E. SCHAFFER, W. A. MULLER, J. RENCOVA, V.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1999</creationdate><title>Effect of oral ZnDTPA on late effects of injected plutonium in rat</title><author>VOLF, A. LUZ, E. SCHAFFER, W. A. MULLER, J. RENCOVA, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-379f6aeddfdbf2f7e71df795243d3bed0d9ab900e7583a59014fa0e92e548cbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - radiation effects</topic><topic>Bone Neoplasms - prevention & control</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glomerulosclerosis, Focal Segmental - chemically induced</topic><topic>Male</topic><topic>Mammary Neoplasms, Experimental - prevention & control</topic><topic>Miscellaneous</topic><topic>Osteosarcoma - prevention & control</topic><topic>Pentetic Acid - pharmacology</topic><topic>Pentetic Acid - toxicity</topic><topic>Plutonium - pharmacokinetics</topic><topic>Plutonium - toxicity</topic><topic>Radiometry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Tissue Distribution - drug effects</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VOLF, A. LUZ, E. SCHAFFER, W. A. MULLER, J. RENCOVA, V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VOLF, A. LUZ, E. SCHAFFER, W. A. MULLER, J. RENCOVA, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of oral ZnDTPA on late effects of injected plutonium in rat</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1999</date><risdate>1999</risdate><volume>75</volume><issue>8</issue><spage>929</spage><epage>941</epage><pages>929-941</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>Purpose: To reduce the long-term toxicity of 239Pu in rats by lifetime drinking of ZnDTPA solution and to investigate possible side-effects of the drug. Materials and methods: Male Sprague-Dawley rats received a single injection of 239Pu citrate, alone or plus oral ZnDTPA. Additional groups were administered only ZnDTPA. Late tissue changes were evaluated by post-mortem examination, X-rays and histologically. Results: The incidence of rat bearing osteosarcoma decreased after treatment to 35% as compared with 53% in untreated controls. The proportional incidence of osteosarcomas was reduced after ZnDTPA by more than the corresponding removal of 239Pu. Unexpectedly in the male rat, mammary tumours, mostly malignant, developed in 20% of rats that received 239Pu as compared with 0.5% in the untreated controls. After a lifetime drinking solely 3x10-3 m ZnDTPA the incidence of diffuse glomerulosclerosis reached 29% as compared with 10% in controls. Conclusions: In rat, protracted oral administration of ZnDTPA reduced the incidence of osteosarcomas after injection of 239Pu, even if treatment started with a delay of 1 month. In the latter case, however, more soft tissue damage was found than after treatment beginning at 4 days post-239Pu. An increased incidence of diffuse glomerulosclerosis was observed as a side effect of oral ZnDTPA only when given continuously, alone and in high amounts.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>10465359</pmid><doi>10.1080/095530099139692</doi><tpages>13</tpages></addata></record> |
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subjects | Administration, Oral Animals Biological and medical sciences Biological effects of radiation Bone and Bones - drug effects Bone and Bones - radiation effects Bone Neoplasms - prevention & control Fundamental and applied biological sciences. Psychology Glomerulosclerosis, Focal Segmental - chemically induced Male Mammary Neoplasms, Experimental - prevention & control Miscellaneous Osteosarcoma - prevention & control Pentetic Acid - pharmacology Pentetic Acid - toxicity Plutonium - pharmacokinetics Plutonium - toxicity Radiometry Rats Rats, Sprague-Dawley Survival Rate Time Factors Tissue Distribution - drug effects Tissues, organs and organisms biophysics |
title | Effect of oral ZnDTPA on late effects of injected plutonium in rat |
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