DESIGN AND CHARACTERIZATION OF SEVELAMER HYDROCHLORIDE: A NOVEL PHOSPHATE-BINDING PHARMACEUTICAL
Sevelamer hydrochloride (polyallylamine crosslinked with epichlorohydrin) is a polymeric hydrogel that has been developed as an oral pharmaceutical to prevent the absorption of dietary phosphate by kidney dialysis patients. It has been found to bind to phosphate in vitro, and to do so more effective...
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| Veröffentlicht in: | Journal of macromolecular science. Part A, Pure and applied chemistry Pure and applied chemistry, 1999-01, Vol.36 (7-8), p.1085-1091 |
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| container_end_page | 1091 |
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| container_issue | 7-8 |
| container_start_page | 1085 |
| container_title | Journal of macromolecular science. Part A, Pure and applied chemistry |
| container_volume | 36 |
| creator | HOLMES-FARLEY, S. RANDY MANDEVILLE, W. HARRY WARD, J. MILLER, K. L. |
| description | Sevelamer hydrochloride (polyallylamine crosslinked with epichlorohydrin) is a polymeric hydrogel that has been developed as an oral pharmaceutical to prevent the absorption of dietary phosphate by kidney dialysis patients. It has been found to bind to phosphate in vitro, and to do so more effectively than a wide range of other cationic polymers. It shows a preference for phosphate over other intestinal anions, such as chloride and bicarbonate. The preference for phosphate is believed to be due to its dianion character, and may also involve hydrogen bonding. The absorption of phosphate in vitro is rapid (less than a minute) relative to the time of passage of such a drug through the small intestine (hours). It has also been found to prevent the absorption of dietary phosphate in vivo and in humans, and is presently awaiting FDA approval. |
| doi_str_mv | 10.1080/10601329908951201 |
| format | Article |
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The absorption of phosphate in vitro is rapid (less than a minute) relative to the time of passage of such a drug through the small intestine (hours). It has also been found to prevent the absorption of dietary phosphate in vivo and in humans, and is presently awaiting FDA approval.</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Exact sciences and technology</subject><subject>Medical sciences</subject><subject>Organic polymers</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Properties and characterization</topic><topic>Solution and gel properties</topic><topic>Urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOLMES-FARLEY, S. RANDY</creatorcontrib><creatorcontrib>MANDEVILLE, W. HARRY</creatorcontrib><creatorcontrib>WARD, J.</creatorcontrib><creatorcontrib>MILLER, K. L.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of macromolecular science. Part A, Pure and applied chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOLMES-FARLEY, S. RANDY</au><au>MANDEVILLE, W. HARRY</au><au>WARD, J.</au><au>MILLER, K. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DESIGN AND CHARACTERIZATION OF SEVELAMER HYDROCHLORIDE: A NOVEL PHOSPHATE-BINDING PHARMACEUTICAL</atitle><jtitle>Journal of macromolecular science. Part A, Pure and applied chemistry</jtitle><date>1999-01-01</date><risdate>1999</risdate><volume>36</volume><issue>7-8</issue><spage>1085</spage><epage>1091</epage><pages>1085-1091</pages><issn>1060-1325</issn><eissn>1520-5738</eissn><coden>JSPCE6</coden><abstract>Sevelamer hydrochloride (polyallylamine crosslinked with epichlorohydrin) is a polymeric hydrogel that has been developed as an oral pharmaceutical to prevent the absorption of dietary phosphate by kidney dialysis patients. It has been found to bind to phosphate in vitro, and to do so more effectively than a wide range of other cationic polymers. It shows a preference for phosphate over other intestinal anions, such as chloride and bicarbonate. 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| identifier | ISSN: 1060-1325 |
| ispartof | Journal of macromolecular science. Part A, Pure and applied chemistry, 1999-01, Vol.36 (7-8), p.1085-1091 |
| issn | 1060-1325 1520-5738 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_1878186 |
| source | Taylor & Francis |
| subjects | Applied sciences Biological and medical sciences Exact sciences and technology Medical sciences Organic polymers Pharmacology. Drug treatments Physicochemistry of polymers Properties and characterization Solution and gel properties Urinary system |
| title | DESIGN AND CHARACTERIZATION OF SEVELAMER HYDROCHLORIDE: A NOVEL PHOSPHATE-BINDING PHARMACEUTICAL |
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