Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats

Summary Rats are employed to investigate the role of platelets in thrombus formation under flow conditions in vivo and to evaluate the pre-clinical potential of antiplatelet drugs. While Wistar and Sprague-Dawley (SD) strains are commonly used in thrombosis models, a number of rat strains have been...

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Veröffentlicht in:	Thrombosis and haemostasis 2007-04, Vol.97 (4), p.665-672
Hauptverfasser:	Sudo, Toshiki, Ito, Hideki, Hayashi, Hideki, Nagamura, Yoshie, Toga, Kazuyuki, Yamada, Yoshihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Animal Models Animals Arteriovenous Shunt, Surgical Biological and medical sciences Bleeding Time Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Chlorides Collagen - pharmacology Disease Models, Animal Drug Evaluation, Preclinical - methods Ferric Compounds Fibrinolytic Agents - pharmacology Fundamental and applied biological sciences. Psychology Genetic Variation Hematologic and hematopoietic diseases Medical sciences Molecular and cellular biology platelet aggregation Platelet Aggregation - genetics Platelet Aggregation Inhibitors - pharmacology Platelet diseases and coagulopathies rat Rats - genetics Rats, Inbred ACI - genetics Rats, Inbred BN - genetics Rats, Inbred F344 - genetics Rats, Inbred Lew - genetics Rats, Sprague-Dawley - genetics Rats, Wistar - genetics Receptors, Thrombin - metabolism Species Specificity strain difference Thrombosis - blood Thrombosis - chemically induced Thrombosis - genetics thrombus formation
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