Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats
Summary Rats are employed to investigate the role of platelets in thrombus formation under flow conditions in vivo and to evaluate the pre-clinical potential of antiplatelet drugs. While Wistar and Sprague-Dawley (SD) strains are commonly used in thrombosis models, a number of rat strains have been...
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| Veröffentlicht in: | Thrombosis and haemostasis 2007-04, Vol.97 (4), p.665-672 |
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| creator | Sudo, Toshiki Ito, Hideki Hayashi, Hideki Nagamura, Yoshie Toga, Kazuyuki Yamada, Yoshihisa |
| description | Summary
Rats are employed to investigate the role of platelets in thrombus formation under flow conditions
in vivo
and to evaluate the pre-clinical potential of antiplatelet drugs. While Wistar and Sprague-Dawley (SD) strains are commonly used in thrombosis models, a number of rat strains have been established. Each strain possesses genetically unique characteristics such as hypertension, hyperglycemia or hyperlipidemia. The appropriate selection of a strain might have advantages for physiological and pharmacological studies. Comparative investigation of platelet aggregation among laboratory strains of rats is useful for the development of thrombosis models. In the present study, platelet aggregation response in eight laboratory rat strains, ACI, Brown Norway (BN), Donryu, Fischer 344 (F344), LEW, SD, Wistar and WKAH, were compared. Considerable strain differences were observed in ADP-, collagen- and TRAP-induced platelet aggregation. SD and BN are high-platelet-aggregation strains, while F344 and ACI are low-response strains. In the arteriovenous shunt thrombosis model, SD formed larger thrombi than F344 andWistar rats. In the FeCl 3 -induced thrombosis model with the carotid artery, the time to occlusion of SD was significantly shorter than of F344 and ACI rats. F344 and ACI rats had significantly increased bleeding times compared with SD rat. The present study demonstrates that there are considerable strain differences in platelet aggregation among laboratory rats, which reflect thrombus formation. |
| doi_str_mv | 10.1160/TH06-05-0268 |
| format | Article |
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Rats are employed to investigate the role of platelets in thrombus formation under flow conditions
in vivo
and to evaluate the pre-clinical potential of antiplatelet drugs. While Wistar and Sprague-Dawley (SD) strains are commonly used in thrombosis models, a number of rat strains have been established. Each strain possesses genetically unique characteristics such as hypertension, hyperglycemia or hyperlipidemia. The appropriate selection of a strain might have advantages for physiological and pharmacological studies. Comparative investigation of platelet aggregation among laboratory strains of rats is useful for the development of thrombosis models. In the present study, platelet aggregation response in eight laboratory rat strains, ACI, Brown Norway (BN), Donryu, Fischer 344 (F344), LEW, SD, Wistar and WKAH, were compared. Considerable strain differences were observed in ADP-, collagen- and TRAP-induced platelet aggregation. SD and BN are high-platelet-aggregation strains, while F344 and ACI are low-response strains. In the arteriovenous shunt thrombosis model, SD formed larger thrombi than F344 andWistar rats. In the FeCl 3 -induced thrombosis model with the carotid artery, the time to occlusion of SD was significantly shorter than of F344 and ACI rats. F344 and ACI rats had significantly increased bleeding times compared with SD rat. The present study demonstrates that there are considerable strain differences in platelet aggregation among laboratory rats, which reflect thrombus formation.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/TH06-05-0268</identifier><identifier>PMID: 17393031</identifier><identifier>CODEN: THHADQ</identifier><language>eng</language><publisher>Stuttgart: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Adenosine Diphosphate - pharmacology ; Animal Models ; Animals ; Arteriovenous Shunt, Surgical ; Biological and medical sciences ; Bleeding Time ; Blood coagulation. Blood cells ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Chlorides ; Collagen - pharmacology ; Disease Models, Animal ; Drug Evaluation, Preclinical - methods ; Ferric Compounds ; Fibrinolytic Agents - pharmacology ; Fundamental and applied biological sciences. Psychology ; Genetic Variation ; Hematologic and hematopoietic diseases ; Medical sciences ; Molecular and cellular biology ; platelet aggregation ; Platelet Aggregation - genetics ; Platelet Aggregation Inhibitors - pharmacology ; Platelet diseases and coagulopathies ; rat ; Rats - genetics ; Rats, Inbred ACI - genetics ; Rats, Inbred BN - genetics ; Rats, Inbred F344 - genetics ; Rats, Inbred Lew - genetics ; Rats, Sprague-Dawley - genetics ; Rats, Wistar - genetics ; Receptors, Thrombin - metabolism ; Species Specificity ; strain difference ; Thrombosis - blood ; Thrombosis - chemically induced ; Thrombosis - genetics ; thrombus formation</subject><ispartof>Thrombosis and haemostasis, 2007-04, Vol.97 (4), p.665-672</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c643t-4e34cec69a8417e530c25f70e5b344fd0e7ccde4f9331791166de510b783cc553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH06-05-0268.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1160/TH06-05-0268$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18669875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17393031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sudo, Toshiki</creatorcontrib><creatorcontrib>Ito, Hideki</creatorcontrib><creatorcontrib>Hayashi, Hideki</creatorcontrib><creatorcontrib>Nagamura, Yoshie</creatorcontrib><creatorcontrib>Toga, Kazuyuki</creatorcontrib><creatorcontrib>Yamada, Yoshihisa</creatorcontrib><title>Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
Rats are employed to investigate the role of platelets in thrombus formation under flow conditions
in vivo
and to evaluate the pre-clinical potential of antiplatelet drugs. While Wistar and Sprague-Dawley (SD) strains are commonly used in thrombosis models, a number of rat strains have been established. Each strain possesses genetically unique characteristics such as hypertension, hyperglycemia or hyperlipidemia. The appropriate selection of a strain might have advantages for physiological and pharmacological studies. Comparative investigation of platelet aggregation among laboratory strains of rats is useful for the development of thrombosis models. In the present study, platelet aggregation response in eight laboratory rat strains, ACI, Brown Norway (BN), Donryu, Fischer 344 (F344), LEW, SD, Wistar and WKAH, were compared. Considerable strain differences were observed in ADP-, collagen- and TRAP-induced platelet aggregation. SD and BN are high-platelet-aggregation strains, while F344 and ACI are low-response strains. In the arteriovenous shunt thrombosis model, SD formed larger thrombi than F344 andWistar rats. In the FeCl 3 -induced thrombosis model with the carotid artery, the time to occlusion of SD was significantly shorter than of F344 and ACI rats. F344 and ACI rats had significantly increased bleeding times compared with SD rat. The present study demonstrates that there are considerable strain differences in platelet aggregation among laboratory rats, which reflect thrombus formation.</description><subject>Adenosine Diphosphate - pharmacology</subject><subject>Animal Models</subject><subject>Animals</subject><subject>Arteriovenous Shunt, Surgical</subject><subject>Biological and medical sciences</subject><subject>Bleeding Time</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Chlorides</subject><subject>Collagen - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Ferric Compounds</subject><subject>Fibrinolytic Agents - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>platelet aggregation</subject><subject>Platelet Aggregation - genetics</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet diseases and coagulopathies</subject><subject>rat</subject><subject>Rats - genetics</subject><subject>Rats, Inbred ACI - genetics</subject><subject>Rats, Inbred BN - genetics</subject><subject>Rats, Inbred F344 - genetics</subject><subject>Rats, Inbred Lew - genetics</subject><subject>Rats, Sprague-Dawley - genetics</subject><subject>Rats, Wistar - genetics</subject><subject>Receptors, Thrombin - metabolism</subject><subject>Species Specificity</subject><subject>strain difference</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - chemically induced</subject><subject>Thrombosis - genetics</subject><subject>thrombus formation</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNq1kE2L1TAUhoMoznV051qyceVUk-aj7VIGZ0YYcDOCCyGk6clthjYpSarMvzelF2elK10dTvJwHt4XodeUvKdUkg93N0RWRFSklu0TdKiFbCrZdt-eogNhnFSy5uIMvUjpnhAqeSeeozPasI4RRg_o-zV4yM7glKN2Hg_OWojgDSRc1mXSGSbIWB-PEY46u-Cx9gPOYwxzvyZsQ5z352DxpPsQdQ7xAZeRXqJnVk8JXp3mOfp69enu8qa6_XL9-fLjbWUkZ7niwLgBIzvdctqAYMTUwjYERM84twOBxpgBuO0Yo01XUssBBCV90zJjhGDn6GK_a2JIKYJVS3Szjg-KErWVpLaSFBFqK6ngb3Z8WfsZhkf41EoB3p4AnYyebNTeuPTItVJ2bbN53-1cHh3MoO7DGn0J-iftvNPJjDpnvUL8fXKvM6RiKe2qUcMcUtbbboLP4HP5iGZ0P0C5lFZQaQHj9KRm7ddkoluyagmtVRrDTzXmeSo-8_99xeL-oaVh_C-JfgGCZfr2</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Sudo, Toshiki</creator><creator>Ito, Hideki</creator><creator>Hayashi, Hideki</creator><creator>Nagamura, Yoshie</creator><creator>Toga, Kazuyuki</creator><creator>Yamada, Yoshihisa</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer GmbH</general><general>Schattauer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20070401</creationdate><title>Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats</title><author>Sudo, Toshiki ; Ito, Hideki ; Hayashi, Hideki ; Nagamura, Yoshie ; Toga, Kazuyuki ; Yamada, Yoshihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c643t-4e34cec69a8417e530c25f70e5b344fd0e7ccde4f9331791166de510b783cc553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenosine Diphosphate - pharmacology</topic><topic>Animal Models</topic><topic>Animals</topic><topic>Arteriovenous Shunt, Surgical</topic><topic>Biological and medical sciences</topic><topic>Bleeding Time</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Chlorides</topic><topic>Collagen - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Ferric Compounds</topic><topic>Fibrinolytic Agents - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Variation</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>platelet aggregation</topic><topic>Platelet Aggregation - genetics</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Platelet diseases and coagulopathies</topic><topic>rat</topic><topic>Rats - genetics</topic><topic>Rats, Inbred ACI - genetics</topic><topic>Rats, Inbred BN - genetics</topic><topic>Rats, Inbred F344 - genetics</topic><topic>Rats, Inbred Lew - genetics</topic><topic>Rats, Sprague-Dawley - genetics</topic><topic>Rats, Wistar - genetics</topic><topic>Receptors, Thrombin - metabolism</topic><topic>Species Specificity</topic><topic>strain difference</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - chemically induced</topic><topic>Thrombosis - genetics</topic><topic>thrombus formation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sudo, Toshiki</creatorcontrib><creatorcontrib>Ito, Hideki</creatorcontrib><creatorcontrib>Hayashi, Hideki</creatorcontrib><creatorcontrib>Nagamura, Yoshie</creatorcontrib><creatorcontrib>Toga, Kazuyuki</creatorcontrib><creatorcontrib>Yamada, Yoshihisa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sudo, Toshiki</au><au>Ito, Hideki</au><au>Hayashi, Hideki</au><au>Nagamura, Yoshie</au><au>Toga, Kazuyuki</au><au>Yamada, Yoshihisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>97</volume><issue>4</issue><spage>665</spage><epage>672</epage><pages>665-672</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><coden>THHADQ</coden><abstract>Summary
Rats are employed to investigate the role of platelets in thrombus formation under flow conditions
in vivo
and to evaluate the pre-clinical potential of antiplatelet drugs. While Wistar and Sprague-Dawley (SD) strains are commonly used in thrombosis models, a number of rat strains have been established. Each strain possesses genetically unique characteristics such as hypertension, hyperglycemia or hyperlipidemia. The appropriate selection of a strain might have advantages for physiological and pharmacological studies. Comparative investigation of platelet aggregation among laboratory strains of rats is useful for the development of thrombosis models. In the present study, platelet aggregation response in eight laboratory rat strains, ACI, Brown Norway (BN), Donryu, Fischer 344 (F344), LEW, SD, Wistar and WKAH, were compared. Considerable strain differences were observed in ADP-, collagen- and TRAP-induced platelet aggregation. SD and BN are high-platelet-aggregation strains, while F344 and ACI are low-response strains. In the arteriovenous shunt thrombosis model, SD formed larger thrombi than F344 andWistar rats. In the FeCl 3 -induced thrombosis model with the carotid artery, the time to occlusion of SD was significantly shorter than of F344 and ACI rats. F344 and ACI rats had significantly increased bleeding times compared with SD rat. The present study demonstrates that there are considerable strain differences in platelet aggregation among laboratory rats, which reflect thrombus formation.</abstract><cop>Stuttgart</cop><pub>Schattauer Verlag für Medizin und Naturwissenschaften</pub><pmid>17393031</pmid><doi>10.1160/TH06-05-0268</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6245 |
| ispartof | Thrombosis and haemostasis, 2007-04, Vol.97 (4), p.665-672 |
| issn | 0340-6245 2567-689X |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adenosine Diphosphate - pharmacology Animal Models Animals Arteriovenous Shunt, Surgical Biological and medical sciences Bleeding Time Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Chlorides Collagen - pharmacology Disease Models, Animal Drug Evaluation, Preclinical - methods Ferric Compounds Fibrinolytic Agents - pharmacology Fundamental and applied biological sciences. Psychology Genetic Variation Hematologic and hematopoietic diseases Medical sciences Molecular and cellular biology platelet aggregation Platelet Aggregation - genetics Platelet Aggregation Inhibitors - pharmacology Platelet diseases and coagulopathies rat Rats - genetics Rats, Inbred ACI - genetics Rats, Inbred BN - genetics Rats, Inbred F344 - genetics Rats, Inbred Lew - genetics Rats, Sprague-Dawley - genetics Rats, Wistar - genetics Receptors, Thrombin - metabolism Species Specificity strain difference Thrombosis - blood Thrombosis - chemically induced Thrombosis - genetics thrombus formation |
| title | Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats |
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