Protective Effect of Carbopol on Enzymatic Degradation of a Peptide-Like Substrate I: Effect of Various Concentrations and Grades of Carbopol and Other Reaction Variables on Trypsin Activity

The purpose of this study was to determine and compare the effect of various concentrations and grades of Carbopol on trypsin-induced degradation of a prototype substrate, Nα-benzoyl-L-arginine ethyl ester hydrochloride (BAEE). Effect of other reaction variables, such as viscosity and ionic strength...

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Veröffentlicht in:	Pharmaceutical development and technology 2007, Vol.12 (1), p.89-96
Hauptverfasser:	Vaidya, A.P., Wigent, R.J., Moore, J.C., Schwartz, J.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins Animals Arginine - analogs & derivatives Arginine - chemistry Biological and medical sciences Cattle Chemistry, Pharmaceutical Chromatography, High Pressure Liquid enzymatic hydrolysis enzyme inhibition General pharmacology Hydrogen-Ion Concentration Hydrolysis ionic strength mechanism of inhibition Medical sciences Peptides - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyvinyls - chemistry Polyvinyls - pharmacology Trypsin - chemistry Trypsin Inhibitors Viscosity
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