Changes in peripheral blood lymphocyte subsets in patients undergoing radiotherapy
Purpose: To investigate the changes in peripheral blood lymphocyte subpopulations in patients undergoing radiotherapy. Materials and methods: In 8 patients undergoing external beam radiotherapy to the pelvis, the different lymphocyte subpopulations were followed during treatment. The lymphocyte popu...
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Veröffentlicht in: | International journal of radiation biology 1999, Vol.75 (6), p.767-771 |
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description | Purpose: To investigate the changes in peripheral blood lymphocyte subpopulations in patients undergoing radiotherapy. Materials and methods: In 8 patients undergoing external beam radiotherapy to the pelvis, the different lymphocyte subpopulations were followed during treatment. The lymphocyte populations were determined using two-colour flow cytometry. The study comprises the T-helper, T-suppressor/cytotoxic cells, the B-lymphocytes and natural killer (NK) cells. Results: The B-cells were characterized by a steep decrease at the beginning of the radiotherapy. They reached their lowest level at an equivalent total body dose of 1.5Gy and remained constant during the rest of the therapy (10% of the initial level). In T-cells (both T-helper and T-suppressor subsets) the steep decrease was less pronounced. T-lymphocytes reached a base level at 2.5Gy equivalent total body dose (20% of the initial level). No significant differences between the T-helper and the T-suppressor/cytotoxic cells were observed. NK cells were characterized by a weak decline during the first weeks of therapy, being less pronounced than in the other populations. Near the end of therapy, the NK cells reached the level of the T-lymphocytes. Conclusion: In vivo, NK cells were the most radioresistant and B-cells the most radiosensitive lymphocytes. No significant differences between T-helper and T-suppressor/cytotoxic cells were observed. These data are in agreement with the differences in apoptosis induction in peripheral blood lymphocyte subpopulations after in vitro gamma-irradiation of whole blood lymphocytes. |
doi_str_mv | 10.1080/095530099140113 |
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VAN EIJKEREN, J. PHILIPPE, H. THIERENS, L. de RIDDER, H.</creator><creatorcontrib>LOUAGIE, M. VAN EIJKEREN, J. PHILIPPE, H. THIERENS, L. de RIDDER, H.</creatorcontrib><description>Purpose: To investigate the changes in peripheral blood lymphocyte subpopulations in patients undergoing radiotherapy. Materials and methods: In 8 patients undergoing external beam radiotherapy to the pelvis, the different lymphocyte subpopulations were followed during treatment. The lymphocyte populations were determined using two-colour flow cytometry. The study comprises the T-helper, T-suppressor/cytotoxic cells, the B-lymphocytes and natural killer (NK) cells. Results: The B-cells were characterized by a steep decrease at the beginning of the radiotherapy. They reached their lowest level at an equivalent total body dose of 1.5Gy and remained constant during the rest of the therapy (10% of the initial level). In T-cells (both T-helper and T-suppressor subsets) the steep decrease was less pronounced. T-lymphocytes reached a base level at 2.5Gy equivalent total body dose (20% of the initial level). No significant differences between the T-helper and the T-suppressor/cytotoxic cells were observed. NK cells were characterized by a weak decline during the first weeks of therapy, being less pronounced than in the other populations. Near the end of therapy, the NK cells reached the level of the T-lymphocytes. Conclusion: In vivo, NK cells were the most radioresistant and B-cells the most radiosensitive lymphocytes. No significant differences between T-helper and T-suppressor/cytotoxic cells were observed. These data are in agreement with the differences in apoptosis induction in peripheral blood lymphocyte subpopulations after in vitro gamma-irradiation of whole blood lymphocytes.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/095530099140113</identifier><identifier>PMID: 10405007</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Adult ; Aged ; Apoptosis - radiation effects ; Biological and medical sciences ; Cell physiology ; Dose-Response Relationship, Radiation ; Effects of physical and chemical agents ; Endometrial Neoplasms - immunology ; Endometrial Neoplasms - radiotherapy ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Killer Cells, Natural - radiation effects ; Lymphocyte Subsets - radiation effects ; Middle Aged ; Molecular and cellular biology ; Radiation Tolerance ; Uterine Cervical Neoplasms - immunology ; Uterine Cervical Neoplasms - radiotherapy</subject><ispartof>International journal of radiation biology, 1999, Vol.75 (6), p.767-771</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-790d61cbc0ecfd1413e81415542ff9172cd68446e12851a3e0d761b5380b3c8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/095530099140113$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/095530099140113$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1854781$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10405007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOUAGIE, M. VAN EIJKEREN, J. PHILIPPE, H. THIERENS, L. de RIDDER, H.</creatorcontrib><title>Changes in peripheral blood lymphocyte subsets in patients undergoing radiotherapy</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>Purpose: To investigate the changes in peripheral blood lymphocyte subpopulations in patients undergoing radiotherapy. Materials and methods: In 8 patients undergoing external beam radiotherapy to the pelvis, the different lymphocyte subpopulations were followed during treatment. The lymphocyte populations were determined using two-colour flow cytometry. The study comprises the T-helper, T-suppressor/cytotoxic cells, the B-lymphocytes and natural killer (NK) cells. Results: The B-cells were characterized by a steep decrease at the beginning of the radiotherapy. They reached their lowest level at an equivalent total body dose of 1.5Gy and remained constant during the rest of the therapy (10% of the initial level). In T-cells (both T-helper and T-suppressor subsets) the steep decrease was less pronounced. T-lymphocytes reached a base level at 2.5Gy equivalent total body dose (20% of the initial level). No significant differences between the T-helper and the T-suppressor/cytotoxic cells were observed. NK cells were characterized by a weak decline during the first weeks of therapy, being less pronounced than in the other populations. Near the end of therapy, the NK cells reached the level of the T-lymphocytes. Conclusion: In vivo, NK cells were the most radioresistant and B-cells the most radiosensitive lymphocytes. No significant differences between T-helper and T-suppressor/cytotoxic cells were observed. These data are in agreement with the differences in apoptosis induction in peripheral blood lymphocyte subpopulations after in vitro gamma-irradiation of whole blood lymphocytes.</description><subject>Adult</subject><subject>Aged</subject><subject>Apoptosis - radiation effects</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Effects of physical and chemical agents</subject><subject>Endometrial Neoplasms - immunology</subject><subject>Endometrial Neoplasms - radiotherapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Killer Cells, Natural - radiation effects</subject><subject>Lymphocyte Subsets - radiation effects</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Radiation Tolerance</subject><subject>Uterine Cervical Neoplasms - immunology</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAURoMozji6didduK3eNH2k7mTwBQOC6Lqkye00Q9uUpIP035uhIz5gNslHcs4l-Qi5pHBDgcMt5EnCAPKcxkApOyJzytIoZP78mMx3tz5DNCNnzm3AJ2D8lMwoxJAAZHPytqxFt0YX6C7o0eq-RiuaoGyMUUEztn1t5Dhg4Lalw2HCxKCx83nbKbRro7t1YIXSZti5_XhOTirROLzY7wvy8fjwvnwOV69PL8v7VSjjiA1hloNKqSwloKwUjSlD7tckiaOqymkWSZXyOE6RRjyhgiGoLKVlwjiUTHJkC3I7zZXWOGexKnqrW2HHgkKxa6f41443riaj35Ytql_8VIcHrveAcFI0lRWd1O6H40mcceqxuwnTXWVsKz6NbVQxiLEx9tthhx-R_5FrFM1QS2Gx2Jit7XxlBz_wBehYkNY</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>LOUAGIE, M. VAN EIJKEREN, J. PHILIPPE, H. THIERENS, L. de RIDDER, H.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1999</creationdate><title>Changes in peripheral blood lymphocyte subsets in patients undergoing radiotherapy</title><author>LOUAGIE, M. VAN EIJKEREN, J. PHILIPPE, H. THIERENS, L. de RIDDER, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-790d61cbc0ecfd1413e81415542ff9172cd68446e12851a3e0d761b5380b3c8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apoptosis - radiation effects</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Effects of physical and chemical agents</topic><topic>Endometrial Neoplasms - immunology</topic><topic>Endometrial Neoplasms - radiotherapy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Killer Cells, Natural - radiation effects</topic><topic>Lymphocyte Subsets - radiation effects</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>Radiation Tolerance</topic><topic>Uterine Cervical Neoplasms - immunology</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOUAGIE, M. VAN EIJKEREN, J. PHILIPPE, H. THIERENS, L. de RIDDER, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LOUAGIE, M. VAN EIJKEREN, J. PHILIPPE, H. THIERENS, L. de RIDDER, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in peripheral blood lymphocyte subsets in patients undergoing radiotherapy</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1999</date><risdate>1999</risdate><volume>75</volume><issue>6</issue><spage>767</spage><epage>771</epage><pages>767-771</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>Purpose: To investigate the changes in peripheral blood lymphocyte subpopulations in patients undergoing radiotherapy. Materials and methods: In 8 patients undergoing external beam radiotherapy to the pelvis, the different lymphocyte subpopulations were followed during treatment. The lymphocyte populations were determined using two-colour flow cytometry. The study comprises the T-helper, T-suppressor/cytotoxic cells, the B-lymphocytes and natural killer (NK) cells. Results: The B-cells were characterized by a steep decrease at the beginning of the radiotherapy. They reached their lowest level at an equivalent total body dose of 1.5Gy and remained constant during the rest of the therapy (10% of the initial level). In T-cells (both T-helper and T-suppressor subsets) the steep decrease was less pronounced. T-lymphocytes reached a base level at 2.5Gy equivalent total body dose (20% of the initial level). No significant differences between the T-helper and the T-suppressor/cytotoxic cells were observed. NK cells were characterized by a weak decline during the first weeks of therapy, being less pronounced than in the other populations. Near the end of therapy, the NK cells reached the level of the T-lymphocytes. Conclusion: In vivo, NK cells were the most radioresistant and B-cells the most radiosensitive lymphocytes. No significant differences between T-helper and T-suppressor/cytotoxic cells were observed. These data are in agreement with the differences in apoptosis induction in peripheral blood lymphocyte subpopulations after in vitro gamma-irradiation of whole blood lymphocytes.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>10405007</pmid><doi>10.1080/095530099140113</doi><tpages>5</tpages></addata></record> |
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subjects | Adult Aged Apoptosis - radiation effects Biological and medical sciences Cell physiology Dose-Response Relationship, Radiation Effects of physical and chemical agents Endometrial Neoplasms - immunology Endometrial Neoplasms - radiotherapy Female Fundamental and applied biological sciences. Psychology Humans Killer Cells, Natural - radiation effects Lymphocyte Subsets - radiation effects Middle Aged Molecular and cellular biology Radiation Tolerance Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - radiotherapy |
title | Changes in peripheral blood lymphocyte subsets in patients undergoing radiotherapy |
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