JASMONATES INDUCE APOPTOSIS AND CELL CYCLE ARREST IN NON-SMALL CELL LUNG CANCER LINES
The jasmonates, cis-jasmone (CJ) and methyl jasmonate (MJ), were investigated for their effects against NSCLC cell lines A549 and H520. CJ or MJ inhibited the proliferation of both cell lines in a dose-dependent manner as well as induced cell cycle arrest in the G2/M phase. Apoptosis was observed fo...
Gespeichert in:
| Veröffentlicht in: | Experimental lung research 2006-11, Vol.32 (10), p.499-516 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 516 |
|---|---|
| container_issue | 10 |
| container_start_page | 499 |
| container_title | Experimental lung research |
| container_volume | 32 |
| creator | Yeruva, Laxmi Pierre, Keon J. Carper, Stephen W. Elegbede, J. Abiodun Toy, Beau J. Wang, Robert C. |
| description | The jasmonates, cis-jasmone (CJ) and methyl jasmonate (MJ), were investigated for their effects against NSCLC cell lines A549 and H520. CJ or MJ inhibited the proliferation of both cell lines in a dose-dependent manner as well as induced cell cycle arrest in the G2/M phase. Apoptosis was observed following treatment with CJ or MJ as indicated by Hoechst staining and confirmed by dual annexin V-fluorescein isothiocyanate (FITC)/prodium iodide (PI) and DAPI (4′,6-diamidine-2′-phenylindole dihydrochloride) staining. p38 and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation was observed with increased expression of bax, p21, and caspase-3 activity. These observations indicate that jasmonates may have a therapeutic value in the treatment of lung cancer. |
| doi_str_mv | 10.1080/01902140601059604 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_18470604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68252426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-2f7246a9cae9e107bb7521a175e295cc60ce80411c2541dbc6b5e399a66637cf3</originalsourceid><addsrcrecordid>eNp9kMFPwjAYxRujEUT_AC9mF71Nv3Ztt0Yvy5iImRthcPC0dKWLmMGwhRj-e0fAGGPi6Tu833t530PoEsMthgDuAAsgmAIHDExwoEeoixnBLlAhjlF3p7stEHTQmbXvAEBYwE9RB_uYi4DxLpo-h_lLloaTOHeGaX8axU44ykaTLB_mTpj2nShOEid6jZJWGI_jfNJiTpqlbv4S7pSdnEzTgROFaRSPnWSYxvk5OqlkbfXF4fbQ9DGeRE9ukg2GUZi4inp07ZLKJ5RLoaQWGoNfln7bXmKfaSKYUhyUDoBirAijeFYqXjLtCSE5556vKq-Hbva5K9N8bLRdF4u5Vbqu5VI3G1vwgDBCCW9BvAeVaaw1uipWZr6QZltgKHZbFn-2bD1Xh_BNudCzH8dhvBa4PgDSKllXRi7V3P5wAfVhH_Sw5-bLqjEL-dmYelas5bZuzLfJ-6_H_S_7m5b1-k1Jo4v3ZmOW7cD_fPEF_nWXiA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68252426</pqid></control><display><type>article</type><title>JASMONATES INDUCE APOPTOSIS AND CELL CYCLE ARREST IN NON-SMALL CELL LUNG CANCER LINES</title><source>MEDLINE</source><source>Taylor & Francis:Master (3349 titles)</source><creator>Yeruva, Laxmi ; Pierre, Keon J. ; Carper, Stephen W. ; Elegbede, J. Abiodun ; Toy, Beau J. ; Wang, Robert C.</creator><creatorcontrib>Yeruva, Laxmi ; Pierre, Keon J. ; Carper, Stephen W. ; Elegbede, J. Abiodun ; Toy, Beau J. ; Wang, Robert C.</creatorcontrib><description>The jasmonates, cis-jasmone (CJ) and methyl jasmonate (MJ), were investigated for their effects against NSCLC cell lines A549 and H520. CJ or MJ inhibited the proliferation of both cell lines in a dose-dependent manner as well as induced cell cycle arrest in the G2/M phase. Apoptosis was observed following treatment with CJ or MJ as indicated by Hoechst staining and confirmed by dual annexin V-fluorescein isothiocyanate (FITC)/prodium iodide (PI) and DAPI (4′,6-diamidine-2′-phenylindole dihydrochloride) staining. p38 and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation was observed with increased expression of bax, p21, and caspase-3 activity. These observations indicate that jasmonates may have a therapeutic value in the treatment of lung cancer.</description><identifier>ISSN: 0190-2148</identifier><identifier>EISSN: 1521-0499</identifier><identifier>DOI: 10.1080/01902140601059604</identifier><identifier>PMID: 17169856</identifier><identifier>CODEN: EXLRDA</identifier><language>eng</language><publisher>Philadelphia, PA: Informa UK Ltd</publisher><subject>A549 ; Acetates - pharmacology ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; Apoptosis Regulatory Proteins - metabolism ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - pathology ; Cell Cycle - drug effects ; Cell Line, Tumor ; CIS-jasmone ; Cyclopentanes - pharmacology ; H520 ; Humans ; Lung Neoplasms - drug therapy ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Medical sciences ; methyl jasmonate ; Neoplasm Proteins - metabolism ; Oxylipins ; Pneumology</subject><ispartof>Experimental lung research, 2006-11, Vol.32 (10), p.499-516</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-2f7246a9cae9e107bb7521a175e295cc60ce80411c2541dbc6b5e399a66637cf3</citedby><cites>FETCH-LOGICAL-c434t-2f7246a9cae9e107bb7521a175e295cc60ce80411c2541dbc6b5e399a66637cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/01902140601059604$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/01902140601059604$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,59646,60435,61220,61401</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18470604$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17169856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeruva, Laxmi</creatorcontrib><creatorcontrib>Pierre, Keon J.</creatorcontrib><creatorcontrib>Carper, Stephen W.</creatorcontrib><creatorcontrib>Elegbede, J. Abiodun</creatorcontrib><creatorcontrib>Toy, Beau J.</creatorcontrib><creatorcontrib>Wang, Robert C.</creatorcontrib><title>JASMONATES INDUCE APOPTOSIS AND CELL CYCLE ARREST IN NON-SMALL CELL LUNG CANCER LINES</title><title>Experimental lung research</title><addtitle>Exp Lung Res</addtitle><description>The jasmonates, cis-jasmone (CJ) and methyl jasmonate (MJ), were investigated for their effects against NSCLC cell lines A549 and H520. CJ or MJ inhibited the proliferation of both cell lines in a dose-dependent manner as well as induced cell cycle arrest in the G2/M phase. Apoptosis was observed following treatment with CJ or MJ as indicated by Hoechst staining and confirmed by dual annexin V-fluorescein isothiocyanate (FITC)/prodium iodide (PI) and DAPI (4′,6-diamidine-2′-phenylindole dihydrochloride) staining. p38 and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation was observed with increased expression of bax, p21, and caspase-3 activity. These observations indicate that jasmonates may have a therapeutic value in the treatment of lung cancer.</description><subject>A549</subject><subject>Acetates - pharmacology</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis Regulatory Proteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Line, Tumor</subject><subject>CIS-jasmone</subject><subject>Cyclopentanes - pharmacology</subject><subject>H520</subject><subject>Humans</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>methyl jasmonate</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Oxylipins</subject><subject>Pneumology</subject><issn>0190-2148</issn><issn>1521-0499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFPwjAYxRujEUT_AC9mF71Nv3Ztt0Yvy5iImRthcPC0dKWLmMGwhRj-e0fAGGPi6Tu833t530PoEsMthgDuAAsgmAIHDExwoEeoixnBLlAhjlF3p7stEHTQmbXvAEBYwE9RB_uYi4DxLpo-h_lLloaTOHeGaX8axU44ykaTLB_mTpj2nShOEid6jZJWGI_jfNJiTpqlbv4S7pSdnEzTgROFaRSPnWSYxvk5OqlkbfXF4fbQ9DGeRE9ukg2GUZi4inp07ZLKJ5RLoaQWGoNfln7bXmKfaSKYUhyUDoBirAijeFYqXjLtCSE5556vKq-Hbva5K9N8bLRdF4u5Vbqu5VI3G1vwgDBCCW9BvAeVaaw1uipWZr6QZltgKHZbFn-2bD1Xh_BNudCzH8dhvBa4PgDSKllXRi7V3P5wAfVhH_Sw5-bLqjEL-dmYelas5bZuzLfJ-6_H_S_7m5b1-k1Jo4v3ZmOW7cD_fPEF_nWXiA</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Yeruva, Laxmi</creator><creator>Pierre, Keon J.</creator><creator>Carper, Stephen W.</creator><creator>Elegbede, J. Abiodun</creator><creator>Toy, Beau J.</creator><creator>Wang, Robert C.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>JASMONATES INDUCE APOPTOSIS AND CELL CYCLE ARREST IN NON-SMALL CELL LUNG CANCER LINES</title><author>Yeruva, Laxmi ; Pierre, Keon J. ; Carper, Stephen W. ; Elegbede, J. Abiodun ; Toy, Beau J. ; Wang, Robert C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-2f7246a9cae9e107bb7521a175e295cc60ce80411c2541dbc6b5e399a66637cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>A549</topic><topic>Acetates - pharmacology</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis Regulatory Proteins - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Line, Tumor</topic><topic>CIS-jasmone</topic><topic>Cyclopentanes - pharmacology</topic><topic>H520</topic><topic>Humans</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>methyl jasmonate</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Oxylipins</topic><topic>Pneumology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeruva, Laxmi</creatorcontrib><creatorcontrib>Pierre, Keon J.</creatorcontrib><creatorcontrib>Carper, Stephen W.</creatorcontrib><creatorcontrib>Elegbede, J. Abiodun</creatorcontrib><creatorcontrib>Toy, Beau J.</creatorcontrib><creatorcontrib>Wang, Robert C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental lung research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeruva, Laxmi</au><au>Pierre, Keon J.</au><au>Carper, Stephen W.</au><au>Elegbede, J. Abiodun</au><au>Toy, Beau J.</au><au>Wang, Robert C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>JASMONATES INDUCE APOPTOSIS AND CELL CYCLE ARREST IN NON-SMALL CELL LUNG CANCER LINES</atitle><jtitle>Experimental lung research</jtitle><addtitle>Exp Lung Res</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>32</volume><issue>10</issue><spage>499</spage><epage>516</epage><pages>499-516</pages><issn>0190-2148</issn><eissn>1521-0499</eissn><coden>EXLRDA</coden><abstract>The jasmonates, cis-jasmone (CJ) and methyl jasmonate (MJ), were investigated for their effects against NSCLC cell lines A549 and H520. CJ or MJ inhibited the proliferation of both cell lines in a dose-dependent manner as well as induced cell cycle arrest in the G2/M phase. Apoptosis was observed following treatment with CJ or MJ as indicated by Hoechst staining and confirmed by dual annexin V-fluorescein isothiocyanate (FITC)/prodium iodide (PI) and DAPI (4′,6-diamidine-2′-phenylindole dihydrochloride) staining. p38 and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation was observed with increased expression of bax, p21, and caspase-3 activity. These observations indicate that jasmonates may have a therapeutic value in the treatment of lung cancer.</abstract><cop>Philadelphia, PA</cop><pub>Informa UK Ltd</pub><pmid>17169856</pmid><doi>10.1080/01902140601059604</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0190-2148 |
| ispartof | Experimental lung research, 2006-11, Vol.32 (10), p.499-516 |
| issn | 0190-2148 1521-0499 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_18470604 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | A549 Acetates - pharmacology Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Cycle - drug effects Cell Line, Tumor CIS-jasmone Cyclopentanes - pharmacology H520 Humans Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical sciences methyl jasmonate Neoplasm Proteins - metabolism Oxylipins Pneumology |
| title | JASMONATES INDUCE APOPTOSIS AND CELL CYCLE ARREST IN NON-SMALL CELL LUNG CANCER LINES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T10%3A51%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=JASMONATES%20INDUCE%20APOPTOSIS%20AND%20CELL%20CYCLE%20ARREST%20IN%20NON-SMALL%20CELL%20LUNG%20CANCER%20LINES&rft.jtitle=Experimental%20lung%20research&rft.au=Yeruva,%20Laxmi&rft.date=2006-11-01&rft.volume=32&rft.issue=10&rft.spage=499&rft.epage=516&rft.pages=499-516&rft.issn=0190-2148&rft.eissn=1521-0499&rft.coden=EXLRDA&rft_id=info:doi/10.1080/01902140601059604&rft_dat=%3Cproquest_pasca%3E68252426%3C/proquest_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68252426&rft_id=info:pmid/17169856&rfr_iscdi=true |