Mucosal Immunity to Asymptomatic Entamoeba histolytica and Entamoeba dispar Infection Is Associated with a Peak Intestinal Anti-Lectin Immunoglobulin A Antibody Response
We monitored 93 subjects cured of amebic liver abscess (ALA) and 963 close associate controls in Durban, South Africa, and determined by enzyme-linked immunosorbent assay that the intestinal immunoglobulin A (IgA) antibody response to the Entamoeba histolytica galactose-inhibitable adherence lectin...
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| Veröffentlicht in: | Infection and Immunity 2006-07, Vol.74 (7), p.3897-3903 |
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| creator | Abd-Alla, Mohamed D Jackson, Terry F.G.H Rogers, Tyson Reddy, Selvan Ravdin, Jonathan I |
| description | We monitored 93 subjects cured of amebic liver abscess (ALA) and 963 close associate controls in Durban, South Africa, and determined by enzyme-linked immunosorbent assay that the intestinal immunoglobulin A (IgA) antibody response to the Entamoeba histolytica galactose-inhibitable adherence lectin is most accurately represented by a complex pattern of transitory peaks. One or more intestinal anti-lectin IgA antibody peaks occurred in 85.9% of ALA subjects over 36 months compared to 41.6% of controls (P < 0.0001). ALA subjects exhibited a greater number of anti-lectin IgA antibody peaks (P < 0.0001) than controls. In addition, their peak optical density values were higher (peak numbers 1 to 3, P < 0.003), peaks were of longer duration (for peaks 1 and 2, P |
| doi_str_mv | 10.1128/IAI.02018-05 |
| format | Article |
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One or more intestinal anti-lectin IgA antibody peaks occurred in 85.9% of ALA subjects over 36 months compared to 41.6% of controls (P < 0.0001). ALA subjects exhibited a greater number of anti-lectin IgA antibody peaks (P < 0.0001) than controls. In addition, their peak optical density values were higher (peak numbers 1 to 3, P < 0.003), peaks were of longer duration (for peaks 1 and 2, P <= 0.0054), and there was a shorter time interval between peaks (between 1 and 2 or 2 and 3, P <= 0.0106) than observed for control subjects. A prior E. histolytica infection was associated with the occurrence of an anti-lectin IgA antibody peak (79.1%, P < 0.0001) more so than for Entamoeba dispar infection (57.2%, P < 0.001). The annual number of anti-lectin IgA antibody peaks in ALA subjects was 0.71 per year, compared to just 0.22 in controls (P<0.0001), indicating a higher rate of exposure to the parasite than previously appreciated. Anti-lectin IgA antibody peaks were of higher amplitude following a E. histolytica infection compared to E. dispar (P = 0.01) and, for either, were of greater height in ALA subjects than controls (P < 0.01). ALA subjects demonstrated greater clearance of amebic infection after an anti-lectin IgA antibody peak compared to controls, and only 14.3% remained with a positive culture after the peak, compared to 38.9% in controls (P = 0.035). In summary, this prospective controlled longitudinal study elucidated the dynamic nature of the human intestinal IgA antibody response to E. histolytica and E. dispar infection and revealed that ALA subjects exhibit heightened intestinal anti-lectin IgA antibody peaks that are associated with clearance of E. histolytica and E. dispar infection.]]></description><identifier>ISSN: 0019-9567</identifier><identifier>EISSN: 1098-5522</identifier><identifier>DOI: 10.1128/IAI.02018-05</identifier><identifier>PMID: 16790762</identifier><identifier>CODEN: INFIBR</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adult ; Amibiasis ; Animals ; Antibodies, Protozoan - biosynthesis ; Biological and medical sciences ; Entamoeba dispar ; Entamoeba histolytica ; Entamoeba histolytica - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Fungal and Parasitic Infections ; Human protozoal diseases ; Humans ; Immunity, Mucosal ; Immunoglobulin A - biosynthesis ; Infectious diseases ; Intestinal Mucosa - immunology ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - parasitology ; Lectins - immunology ; Liver Abscess, Amebic - immunology ; Liver Abscess, Amebic - microbiology ; Male ; Medical sciences ; Microbiology ; Parasitic diseases ; Protozoal diseases</subject><ispartof>Infection and Immunity, 2006-07, Vol.74 (7), p.3897-3903</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright © 2006, American Society for Microbiology 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-9d7d40c8e7c06b516fb515d21cf278fc9f84da70a2dc1ab26a7e62c04c06c61e3</citedby><cites>FETCH-LOGICAL-c493t-9d7d40c8e7c06b516fb515d21cf278fc9f84da70a2dc1ab26a7e62c04c06c61e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489685/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489685/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3174,3175,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17899374$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16790762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abd-Alla, Mohamed D</creatorcontrib><creatorcontrib>Jackson, Terry F.G.H</creatorcontrib><creatorcontrib>Rogers, Tyson</creatorcontrib><creatorcontrib>Reddy, Selvan</creatorcontrib><creatorcontrib>Ravdin, Jonathan I</creatorcontrib><title>Mucosal Immunity to Asymptomatic Entamoeba histolytica and Entamoeba dispar Infection Is Associated with a Peak Intestinal Anti-Lectin Immunoglobulin A Antibody Response</title><title>Infection and Immunity</title><addtitle>Infect Immun</addtitle><description><![CDATA[We monitored 93 subjects cured of amebic liver abscess (ALA) and 963 close associate controls in Durban, South Africa, and determined by enzyme-linked immunosorbent assay that the intestinal immunoglobulin A (IgA) antibody response to the Entamoeba histolytica galactose-inhibitable adherence lectin is most accurately represented by a complex pattern of transitory peaks. One or more intestinal anti-lectin IgA antibody peaks occurred in 85.9% of ALA subjects over 36 months compared to 41.6% of controls (P < 0.0001). ALA subjects exhibited a greater number of anti-lectin IgA antibody peaks (P < 0.0001) than controls. In addition, their peak optical density values were higher (peak numbers 1 to 3, P < 0.003), peaks were of longer duration (for peaks 1 and 2, P <= 0.0054), and there was a shorter time interval between peaks (between 1 and 2 or 2 and 3, P <= 0.0106) than observed for control subjects. A prior E. histolytica infection was associated with the occurrence of an anti-lectin IgA antibody peak (79.1%, P < 0.0001) more so than for Entamoeba dispar infection (57.2%, P < 0.001). The annual number of anti-lectin IgA antibody peaks in ALA subjects was 0.71 per year, compared to just 0.22 in controls (P<0.0001), indicating a higher rate of exposure to the parasite than previously appreciated. Anti-lectin IgA antibody peaks were of higher amplitude following a E. histolytica infection compared to E. dispar (P = 0.01) and, for either, were of greater height in ALA subjects than controls (P < 0.01). ALA subjects demonstrated greater clearance of amebic infection after an anti-lectin IgA antibody peak compared to controls, and only 14.3% remained with a positive culture after the peak, compared to 38.9% in controls (P = 0.035). In summary, this prospective controlled longitudinal study elucidated the dynamic nature of the human intestinal IgA antibody response to E. histolytica and E. dispar infection and revealed that ALA subjects exhibit heightened intestinal anti-lectin IgA antibody peaks that are associated with clearance of E. histolytica and E. dispar infection.]]></description><subject>Adult</subject><subject>Amibiasis</subject><subject>Animals</subject><subject>Antibodies, Protozoan - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Entamoeba dispar</subject><subject>Entamoeba histolytica</subject><subject>Entamoeba histolytica - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal and Parasitic Infections</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunity, Mucosal</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Infectious diseases</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - parasitology</subject><subject>Lectins - immunology</subject><subject>Liver Abscess, Amebic - immunology</subject><subject>Liver Abscess, Amebic - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><issn>0019-9567</issn><issn>1098-5522</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhxhnMgZ5IsZ3EHxekVVVKpEUgoGdr4ji7hsReYocqP4l_ibdZ0XLiYmv8Pn5nxp4se07wOSFUvK3X9TmmmIgcVw-yFcFS5FVF6cNshTGRuawYP8mehPA9hWVZisfZCWFcYs7oKvv9cdI-QI_qYZicjTOKHq3DPOyjHyBajS5dhMGbBtDOhuj7OR0CAtfeU1ob9jCi2nVGR-sdqkMyCV5biKZFNzbuEKDPBn4kJpoQrUsp1y7afHO44Zb0ftv7ZupTuL4VG9_O6IsJe--CeZo96qAP5tlxP82u319-u_iQbz5d1RfrTa5LWcRctrwtsRaGa8yairAuLVVLie4oF52WnShb4Bhoqwk0lAE3jGpcJlwzYorT7N3iu5-awbTauDhCr_ajHWCclQer_lWc3amt_6VIKSQTVTI4OxqM_ueUmlWDDdr0PTjjp6CYILiglP0XJJwyzDFN4JsF1KMPYTTd32oIVochUGkI1O0QKHwo4MX9Du7g468n4PURgKCh70Zw2oY7jgspC14m7tXC7ex2d2NHoyAMyqYX4KXiqhCSJ-blwnTgFWzH5HP9NVVSYIJFQTkv_gBJVNLN</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Abd-Alla, Mohamed D</creator><creator>Jackson, Terry F.G.H</creator><creator>Rogers, Tyson</creator><creator>Reddy, Selvan</creator><creator>Ravdin, Jonathan I</creator><general>American Society for Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060701</creationdate><title>Mucosal Immunity to Asymptomatic Entamoeba histolytica and Entamoeba dispar Infection Is Associated with a Peak Intestinal Anti-Lectin Immunoglobulin A Antibody Response</title><author>Abd-Alla, Mohamed D ; Jackson, Terry F.G.H ; Rogers, Tyson ; Reddy, Selvan ; Ravdin, Jonathan I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-9d7d40c8e7c06b516fb515d21cf278fc9f84da70a2dc1ab26a7e62c04c06c61e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Amibiasis</topic><topic>Animals</topic><topic>Antibodies, Protozoan - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Entamoeba dispar</topic><topic>Entamoeba histolytica</topic><topic>Entamoeba histolytica - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal and Parasitic Infections</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunity, Mucosal</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Infectious diseases</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - parasitology</topic><topic>Lectins - immunology</topic><topic>Liver Abscess, Amebic - immunology</topic><topic>Liver Abscess, Amebic - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abd-Alla, Mohamed D</creatorcontrib><creatorcontrib>Jackson, Terry F.G.H</creatorcontrib><creatorcontrib>Rogers, Tyson</creatorcontrib><creatorcontrib>Reddy, Selvan</creatorcontrib><creatorcontrib>Ravdin, Jonathan I</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Infection and Immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abd-Alla, Mohamed D</au><au>Jackson, Terry F.G.H</au><au>Rogers, Tyson</au><au>Reddy, Selvan</au><au>Ravdin, Jonathan I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucosal Immunity to Asymptomatic Entamoeba histolytica and Entamoeba dispar Infection Is Associated with a Peak Intestinal Anti-Lectin Immunoglobulin A Antibody Response</atitle><jtitle>Infection and Immunity</jtitle><addtitle>Infect Immun</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>74</volume><issue>7</issue><spage>3897</spage><epage>3903</epage><pages>3897-3903</pages><issn>0019-9567</issn><eissn>1098-5522</eissn><coden>INFIBR</coden><abstract><![CDATA[We monitored 93 subjects cured of amebic liver abscess (ALA) and 963 close associate controls in Durban, South Africa, and determined by enzyme-linked immunosorbent assay that the intestinal immunoglobulin A (IgA) antibody response to the Entamoeba histolytica galactose-inhibitable adherence lectin is most accurately represented by a complex pattern of transitory peaks. One or more intestinal anti-lectin IgA antibody peaks occurred in 85.9% of ALA subjects over 36 months compared to 41.6% of controls (P < 0.0001). ALA subjects exhibited a greater number of anti-lectin IgA antibody peaks (P < 0.0001) than controls. In addition, their peak optical density values were higher (peak numbers 1 to 3, P < 0.003), peaks were of longer duration (for peaks 1 and 2, P <= 0.0054), and there was a shorter time interval between peaks (between 1 and 2 or 2 and 3, P <= 0.0106) than observed for control subjects. A prior E. histolytica infection was associated with the occurrence of an anti-lectin IgA antibody peak (79.1%, P < 0.0001) more so than for Entamoeba dispar infection (57.2%, P < 0.001). The annual number of anti-lectin IgA antibody peaks in ALA subjects was 0.71 per year, compared to just 0.22 in controls (P<0.0001), indicating a higher rate of exposure to the parasite than previously appreciated. Anti-lectin IgA antibody peaks were of higher amplitude following a E. histolytica infection compared to E. dispar (P = 0.01) and, for either, were of greater height in ALA subjects than controls (P < 0.01). ALA subjects demonstrated greater clearance of amebic infection after an anti-lectin IgA antibody peak compared to controls, and only 14.3% remained with a positive culture after the peak, compared to 38.9% in controls (P = 0.035). In summary, this prospective controlled longitudinal study elucidated the dynamic nature of the human intestinal IgA antibody response to E. histolytica and E. dispar infection and revealed that ALA subjects exhibit heightened intestinal anti-lectin IgA antibody peaks that are associated with clearance of E. histolytica and E. dispar infection.]]></abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>16790762</pmid><doi>10.1128/IAI.02018-05</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Amibiasis Animals Antibodies, Protozoan - biosynthesis Biological and medical sciences Entamoeba dispar Entamoeba histolytica Entamoeba histolytica - immunology Female Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections Human protozoal diseases Humans Immunity, Mucosal Immunoglobulin A - biosynthesis Infectious diseases Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - parasitology Lectins - immunology Liver Abscess, Amebic - immunology Liver Abscess, Amebic - microbiology Male Medical sciences Microbiology Parasitic diseases Protozoal diseases |
| title | Mucosal Immunity to Asymptomatic Entamoeba histolytica and Entamoeba dispar Infection Is Associated with a Peak Intestinal Anti-Lectin Immunoglobulin A Antibody Response |
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