A role for K ATP+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla
Reticulospinal sympathoexcitatory neurons of rostral ventrolateral medulla (RVL) are selectively excited by hypoxia to elevate arterial pressure (AP) and cerebral blood flow (rCBF), that are elements of the oxygen-conserving (diving) reflex. We investigated whether K ATP +-channels participate in th...
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| Veröffentlicht in: | Brain research 1999-05, Vol.827 (1), p.210-214 |
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| creator | Golanov, Eugene V Reis, Donald J |
| description | Reticulospinal sympathoexcitatory neurons of rostral ventrolateral medulla (RVL) are selectively excited by hypoxia to elevate arterial pressure (AP) and cerebral blood flow (rCBF), that are elements of the oxygen-conserving (diving) reflex. We investigated whether K
ATP
+-channels participate in this. Tolbutamide and glibenclamide, K
ATP
+-channel blockers, microinjected into RVL in anesthetized rats, dose-dependently and site-specifically elevated AP and rCBF and potentiated responses to hypoxemia. K
ATP
+-channels may mediate hypoxic excitation of oxygen-sensing RVL neurons. |
| doi_str_mv | 10.1016/S0006-8993(99)01256-1 |
| format | Article |
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ATP
+-channels participate in this. Tolbutamide and glibenclamide, K
ATP
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ATP
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ATP
+-channels participate in this. Tolbutamide and glibenclamide, K
ATP
+-channel blockers, microinjected into RVL in anesthetized rats, dose-dependently and site-specifically elevated AP and rCBF and potentiated responses to hypoxemia. K
ATP
+-channels may mediate hypoxic excitation of oxygen-sensing RVL neurons.</description><subject>Arterial pressure</subject><subject>ATP-sensitive potassium channel</subject><subject>Biological and medical sciences</subject><subject>Cerebral blood flow</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypoxia</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Oxygen</subject><subject>Rostral ventrolateral medulla</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNo9kc1qGzEUhUVpoG6aRyjcRRYpYVppNKOxVsGE_JQGUki6FhrpTqwgS0aS3fjJ-nqRndDV5VwOH4dzCPnK6HdGmfjxQCkVzVxKfiblN8raXjTsA5mx-dA2ou3oRzL7b_lEPuf8XCXnks7IvwWk6BGmmOAXLB5_nzdmqUNAn8EFWKF1urjwBGWJgB63VcWQIU5gMOGYtIfRx2hh8vEv6GBBp4LJ1f86Yc6bhDDuYLlbxxdnIBe32vgDZM-IL7snDE3GkF1xW4SAm_TOTzGXPX6LodSMulKrqok23usv5GjSPuPJ-z0mf66vHi9vm7v7m5-Xi7sG2UBLwwYhKG85M1OnR8F5L2VnukFq2Rvd1zcT1mJvteWGt9Z2lJquG-e8H4Xlmh-T0zfuWmej_ZR0MC6rdXIrnXaKDfNhkH21XbzZam-4dZhUNg6DqfUlNEXZ6BSjaj-XOsyl9lsoKdVhLsX4K1hCjcw</recordid><startdate>19990508</startdate><enddate>19990508</enddate><creator>Golanov, Eugene V</creator><creator>Reis, Donald J</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope></search><sort><creationdate>19990508</creationdate><title>A role for K ATP+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla</title><author>Golanov, Eugene V ; Reis, Donald J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e170t-176603231cf4ab6335994c479a95ca51cf16dde5dad3c32dd400c44b835b6d3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Arterial pressure</topic><topic>ATP-sensitive potassium channel</topic><topic>Biological and medical sciences</topic><topic>Cerebral blood flow</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypoxia</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Oxygen</topic><topic>Rostral ventrolateral medulla</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Golanov, Eugene V</creatorcontrib><creatorcontrib>Reis, Donald J</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golanov, Eugene V</au><au>Reis, Donald J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A role for K ATP+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla</atitle><jtitle>Brain research</jtitle><date>1999-05-08</date><risdate>1999</risdate><volume>827</volume><issue>1</issue><spage>210</spage><epage>214</epage><pages>210-214</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Reticulospinal sympathoexcitatory neurons of rostral ventrolateral medulla (RVL) are selectively excited by hypoxia to elevate arterial pressure (AP) and cerebral blood flow (rCBF), that are elements of the oxygen-conserving (diving) reflex. We investigated whether K
ATP
+-channels participate in this. Tolbutamide and glibenclamide, K
ATP
+-channel blockers, microinjected into RVL in anesthetized rats, dose-dependently and site-specifically elevated AP and rCBF and potentiated responses to hypoxemia. K
ATP
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| fulltext | fulltext |
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| ispartof | Brain research, 1999-05, Vol.827 (1), p.210-214 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings |
| subjects | Arterial pressure ATP-sensitive potassium channel Biological and medical sciences Cerebral blood flow Fundamental and applied biological sciences. Psychology Hypoxia Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Oxygen Rostral ventrolateral medulla Vertebrates: nervous system and sense organs |
| title | A role for K ATP+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla |
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