Genetic and Pharmacological Analyses of Syk Function in αIIbβ3 Signaling in Platelets

Agonists induce inside-out αIIbβ3signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling resulting in further platelet stimulation. Because the Syk tyrosine kinase is activated during both phases of integrin signaling, we evaluated its role in α...

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Veröffentlicht in:	Blood 1999-04, Vol.93 (8), p.2645-2652
Hauptverfasser:	Law, Debbie A., Nannizzi-Alaimo, Lisa, Ministri, Kathleen, Hughes, Paul E., Forsyth, Jane, Turner, Martin, Shattil, Sanford J., Ginsberg, Mark H., Tybulewicz, Victor L.J., Phillips, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood coagulation. Blood cells Fundamental and applied biological sciences. Psychology Molecular and cellular biology Platelet
Online-Zugang:	Volltext
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