Ethanol and its effects on fracture healing and bone mass in male rats
Operatively induced, standardized tibia fractures in 42 10-week-old male rats were fixed with intramedullary nails. 21 of the rats were fed liquid containing 15% ethanol. 5 weeks after inducing the fracture, the rats were killed and the total body bone mineral density (BMD) was analyzed with the DEX...
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| Veröffentlicht in: | Acta orthopaedica 1999, Vol.70 (2), p.212-216 |
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| creator | Nyquist, Fredrik Halvorsen, Vera Madsen, Jan E Nordsletten, Lars Obrant, Karl J |
| description | Operatively induced, standardized tibia fractures in 42 10-week-old male rats were fixed with intramedullary nails. 21 of the rats were fed liquid containing 15% ethanol. 5 weeks after inducing the fracture, the rats were killed and the total body bone mineral density (BMD) was analyzed with the DEXA technique, and the mechanical properties of the fractured and the unfractured tibiae as well as the ipsi- and contralateral femoral shaft and femoral neck were tested. The rats given a liquid containing 15% ethanol were found to have significantly lower total BMD and total calcium than the controls. We also found a significantly lower bending moment and bending stiff ness both in the fractured and unfractured tibiae among rats fed on ethanol. The energy absorption until refracture was less in rats fed on ethanol.
Posttraumatic osteopenia was present, as judged by the mechanical tests of the ipsilateral femoral shaft and the femoral neck in all animals. There was no difference in this respect between the animals fed on ethanol and the controls.
We found that ethanol disturbs bone metabolism which reduces the mechanical properties of the tibiae and femora of rats, but the healing process of an induced tibial shaft fracture was not affected. |
| doi_str_mv | 10.3109/17453679909011265 |
| format | Article |
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Posttraumatic osteopenia was present, as judged by the mechanical tests of the ipsilateral femoral shaft and the femoral neck in all animals. There was no difference in this respect between the animals fed on ethanol and the controls.
We found that ethanol disturbs bone metabolism which reduces the mechanical properties of the tibiae and femora of rats, but the healing process of an induced tibial shaft fracture was not affected.</description><identifier>ISSN: 1745-3674</identifier><identifier>ISSN: 0001-6470</identifier><identifier>EISSN: 1745-3682</identifier><identifier>DOI: 10.3109/17453679909011265</identifier><identifier>PMID: 10366927</identifier><identifier>CODEN: AOSAAK</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Absorptiometry, Photon ; Animals ; Biological and medical sciences ; Biomechanical Phenomena ; Bone Density - drug effects ; Clinical Medicine ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Ethanol - adverse effects ; Fracture Healing - drug effects ; Fundamental and applied biological sciences. Psychology ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Orthopedics ; Ortopedi ; Radionuclide Imaging ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Skeleton and joints ; Tibial Fractures - diagnostic imaging ; Tibial Fractures - metabolism ; Tibial Fractures - pathology ; Tibial Fractures - physiopathology ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Acta orthopaedica, 1999, Vol.70 (2), p.212-216</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-7fd421c4c6421f3bd9291faa780d6c9c23e740abb9f4e893cb2d2e3e835158ee3</citedby><cites>FETCH-LOGICAL-c543t-7fd421c4c6421f3bd9291faa780d6c9c23e740abb9f4e893cb2d2e3e835158ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1776710$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10366927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1114952$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nyquist, Fredrik</creatorcontrib><creatorcontrib>Halvorsen, Vera</creatorcontrib><creatorcontrib>Madsen, Jan E</creatorcontrib><creatorcontrib>Nordsletten, Lars</creatorcontrib><creatorcontrib>Obrant, Karl J</creatorcontrib><title>Ethanol and its effects on fracture healing and bone mass in male rats</title><title>Acta orthopaedica</title><addtitle>Acta Orthop Scand</addtitle><description>Operatively induced, standardized tibia fractures in 42 10-week-old male rats were fixed with intramedullary nails. 21 of the rats were fed liquid containing 15% ethanol. 5 weeks after inducing the fracture, the rats were killed and the total body bone mineral density (BMD) was analyzed with the DEXA technique, and the mechanical properties of the fractured and the unfractured tibiae as well as the ipsi- and contralateral femoral shaft and femoral neck were tested. The rats given a liquid containing 15% ethanol were found to have significantly lower total BMD and total calcium than the controls. We also found a significantly lower bending moment and bending stiff ness both in the fractured and unfractured tibiae among rats fed on ethanol. The energy absorption until refracture was less in rats fed on ethanol.
Posttraumatic osteopenia was present, as judged by the mechanical tests of the ipsilateral femoral shaft and the femoral neck in all animals. There was no difference in this respect between the animals fed on ethanol and the controls.
We found that ethanol disturbs bone metabolism which reduces the mechanical properties of the tibiae and femora of rats, but the healing process of an induced tibial shaft fracture was not affected.</description><subject>Absorptiometry, Photon</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Bone Density - drug effects</subject><subject>Clinical Medicine</subject><subject>Disease Models, Animal</subject><subject>Drug Evaluation, Preclinical</subject><subject>Ethanol - adverse effects</subject><subject>Fracture Healing - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Klinisk medicin</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Orthopedics</subject><subject>Ortopedi</subject><subject>Radionuclide Imaging</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Skeleton and joints</subject><subject>Tibial Fractures - diagnostic imaging</subject><subject>Tibial Fractures - metabolism</subject><subject>Tibial Fractures - pathology</subject><subject>Tibial Fractures - physiopathology</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>1745-3674</issn><issn>0001-6470</issn><issn>1745-3682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV9LHDEUxYMo1W77AfpS5sHXbfNvkgn1RURtYaEv9jncZG66I7PJkswifnuzjtqK4EM4IfzOSXIuIV8Y_SYYNd-Zlq1Q2hhqKGNctQfkZH-2FKrjhy97LY_Jx1JuKRWdNPQDOWZUKGW4PiFXl9MaYhobiH0zTKXBENBXTbEJGfy0y9isEcYh_n1kXIrYbKCUZohVR2wyTOUTOQowFvz8pAvy5-ry5uLncvX7-tfF-WrpWymmpQ695MxLr6oE4XrDDQsAuqO98sZzgVpScM4EiZ0R3vGeo8BOtKztEMWCrObccofbnbPbPGwg39sEgx1327pcXbagdUHooI2yAExYqXtjnaLcgtPKuE4zw2SNY3Ocz6mUjOElkFG7r9i-qbh6vs6eev8G-_8cc6cVOH0CoHgYa4vRD-Ufp7XSFV6QsxkbYkh5A3cpj72d4H5M-dkj3nvGj1f2_YymtYeM9jbtcqxTeOcTD9c-p4Q</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Nyquist, Fredrik</creator><creator>Halvorsen, Vera</creator><creator>Madsen, Jan E</creator><creator>Nordsletten, Lars</creator><creator>Obrant, Karl J</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D95</scope></search><sort><creationdate>1999</creationdate><title>Ethanol and its effects on fracture healing and bone mass in male rats</title><author>Nyquist, Fredrik ; Halvorsen, Vera ; Madsen, Jan E ; Nordsletten, Lars ; Obrant, Karl J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-7fd421c4c6421f3bd9291faa780d6c9c23e740abb9f4e893cb2d2e3e835158ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Absorptiometry, Photon</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Bone Density - drug effects</topic><topic>Clinical Medicine</topic><topic>Disease Models, Animal</topic><topic>Drug Evaluation, Preclinical</topic><topic>Ethanol - adverse effects</topic><topic>Fracture Healing - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Klinisk medicin</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Orthopedics</topic><topic>Ortopedi</topic><topic>Radionuclide Imaging</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Skeleton and joints</topic><topic>Tibial Fractures - diagnostic imaging</topic><topic>Tibial Fractures - metabolism</topic><topic>Tibial Fractures - pathology</topic><topic>Tibial Fractures - physiopathology</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nyquist, Fredrik</creatorcontrib><creatorcontrib>Halvorsen, Vera</creatorcontrib><creatorcontrib>Madsen, Jan E</creatorcontrib><creatorcontrib>Nordsletten, Lars</creatorcontrib><creatorcontrib>Obrant, Karl J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Lunds universitet</collection><jtitle>Acta orthopaedica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nyquist, Fredrik</au><au>Halvorsen, Vera</au><au>Madsen, Jan E</au><au>Nordsletten, Lars</au><au>Obrant, Karl J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanol and its effects on fracture healing and bone mass in male rats</atitle><jtitle>Acta orthopaedica</jtitle><addtitle>Acta Orthop Scand</addtitle><date>1999</date><risdate>1999</risdate><volume>70</volume><issue>2</issue><spage>212</spage><epage>216</epage><pages>212-216</pages><issn>1745-3674</issn><issn>0001-6470</issn><eissn>1745-3682</eissn><coden>AOSAAK</coden><abstract>Operatively induced, standardized tibia fractures in 42 10-week-old male rats were fixed with intramedullary nails. 21 of the rats were fed liquid containing 15% ethanol. 5 weeks after inducing the fracture, the rats were killed and the total body bone mineral density (BMD) was analyzed with the DEXA technique, and the mechanical properties of the fractured and the unfractured tibiae as well as the ipsi- and contralateral femoral shaft and femoral neck were tested. The rats given a liquid containing 15% ethanol were found to have significantly lower total BMD and total calcium than the controls. We also found a significantly lower bending moment and bending stiff ness both in the fractured and unfractured tibiae among rats fed on ethanol. The energy absorption until refracture was less in rats fed on ethanol.
Posttraumatic osteopenia was present, as judged by the mechanical tests of the ipsilateral femoral shaft and the femoral neck in all animals. There was no difference in this respect between the animals fed on ethanol and the controls.
We found that ethanol disturbs bone metabolism which reduces the mechanical properties of the tibiae and femora of rats, but the healing process of an induced tibial shaft fracture was not affected.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>10366927</pmid><doi>10.3109/17453679909011265</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry, Photon Animals Biological and medical sciences Biomechanical Phenomena Bone Density - drug effects Clinical Medicine Disease Models, Animal Drug Evaluation, Preclinical Ethanol - adverse effects Fracture Healing - drug effects Fundamental and applied biological sciences. Psychology Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Orthopedics Ortopedi Radionuclide Imaging Random Allocation Rats Rats, Sprague-Dawley Skeleton and joints Tibial Fractures - diagnostic imaging Tibial Fractures - metabolism Tibial Fractures - pathology Tibial Fractures - physiopathology Vertebrates: osteoarticular system, musculoskeletal system |
| title | Ethanol and its effects on fracture healing and bone mass in male rats |
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