Minimal change in HSV-2 seroreactivity: A cross-sectional Swedish population study
The prevalence of antibodies to herpes simplex virus type 2 (HSV-2) was determined in sera collected from 2 Swedish cross-sectional populations during 1990/91 and 1996/97. A glycoprotein G2 (gG-2) peptide ELISA was used to analyse 2899 sera from adults. We found a prevalence of 13.0% in 18-70-y-olds...
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| Veröffentlicht in: | Scandinavian journal of infectious diseases 2006, Vol.38 (5), p.357-365, Article 357 |
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| creator | Jonsson, Maria K. Levi, Michael Rudén, Ulla Wahren, Britta |
| description | The prevalence of antibodies to herpes simplex virus type 2 (HSV-2) was determined in sera collected from 2 Swedish cross-sectional populations during 1990/91 and 1996/97. A glycoprotein G2 (gG-2) peptide ELISA was used to analyse 2899 sera from adults. We found a prevalence of 13.0% in 18-70-y-olds in 1990/91 and 16.4% in 31-55-y-olds in 1996/97. Seropositivity to HSV-2 was somewhat higher in women than in men; 14.4% compared to 11.6% in 1990/91 and 18.9% compared to 13.6% in 1996/97. Overall there was a significant difference in female prevalence of HSV-2 compared to prevalence in males of the same age groups (p=0.013). Total antibody prevalence to HSV-1 of 88% in HSV-2 negative individuals above 18 y of age was found. HSV-2 positive individuals were found seropositive to HSV-1 in approximately 95% of the cases. 12% were negative for both HSV-1 and HSV-2 antibodies. In addition, there was no serological sign that the reported increase of HSV-1 as an early sexual disease had reduced the frequency of HSV-2 seropositivity in the sexually most active age groups. In conclusion, our investigation has shown no significant increase of HSV-2 seroprevalence in randomly selected Swedish subjects during the defined time period. |
| doi_str_mv | 10.1080/00365540500488865 |
| format | Article |
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A glycoprotein G2 (gG-2) peptide ELISA was used to analyse 2899 sera from adults. We found a prevalence of 13.0% in 18-70-y-olds in 1990/91 and 16.4% in 31-55-y-olds in 1996/97. Seropositivity to HSV-2 was somewhat higher in women than in men; 14.4% compared to 11.6% in 1990/91 and 18.9% compared to 13.6% in 1996/97. Overall there was a significant difference in female prevalence of HSV-2 compared to prevalence in males of the same age groups (p=0.013). Total antibody prevalence to HSV-1 of 88% in HSV-2 negative individuals above 18 y of age was found. HSV-2 positive individuals were found seropositive to HSV-1 in approximately 95% of the cases. 12% were negative for both HSV-1 and HSV-2 antibodies. In addition, there was no serological sign that the reported increase of HSV-1 as an early sexual disease had reduced the frequency of HSV-2 seropositivity in the sexually most active age groups. 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A glycoprotein G2 (gG-2) peptide ELISA was used to analyse 2899 sera from adults. We found a prevalence of 13.0% in 18-70-y-olds in 1990/91 and 16.4% in 31-55-y-olds in 1996/97. Seropositivity to HSV-2 was somewhat higher in women than in men; 14.4% compared to 11.6% in 1990/91 and 18.9% compared to 13.6% in 1996/97. Overall there was a significant difference in female prevalence of HSV-2 compared to prevalence in males of the same age groups (p=0.013). Total antibody prevalence to HSV-1 of 88% in HSV-2 negative individuals above 18 y of age was found. HSV-2 positive individuals were found seropositive to HSV-1 in approximately 95% of the cases. 12% were negative for both HSV-1 and HSV-2 antibodies. In addition, there was no serological sign that the reported increase of HSV-1 as an early sexual disease had reduced the frequency of HSV-2 seropositivity in the sexually most active age groups. In conclusion, our investigation has shown no significant increase of HSV-2 seroprevalence in randomly selected Swedish subjects during the defined time period.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Female</subject><subject>Herpes Genitalis - epidemiology</subject><subject>Herpes Genitalis - transmission</subject><subject>Herpes Simplex - epidemiology</subject><subject>Herpes Simplex - transmission</subject><subject>Herpes simplex virus 1</subject><subject>Herpes simplex virus 2</subject><subject>Herpesvirus 1, Human - immunology</subject><subject>Herpesvirus 2, Human - immunology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Seroepidemiologic Studies</subject><subject>Sex Factors</subject><subject>Sweden - epidemiology</subject><issn>0036-5548</issn><issn>1651-1980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxS0EotvCB-CCcoFbYOzEcQJcqqp_kIqQKHC1Jo7Dunjj1Ha62m9fbzdQAdJysvX8e57xPBPygsIbCjW8BSgqzkvgAGVd1xV_RBa04jSnTQ2PyWJ7niegPiCHIVxDwqoCnpIDWgloeFEvyJdPZjArtJla4vBDZ2bILq6-5ywL2juvUUVza-LmXXacKe9CyINOkhuS42qtOxOW2ejGyeJWzEKcus0z8qRHG_TzeT0i385Ov55c5Jefzz-eHF_mikMR8wqwQdqXjHWIwJlSOimU8bIHEJo2oqVcIRY9bzrasJ7RMuFdW9JWcdUWRyTf3RvWepxaOfr0EL-RDo2cpZ9ppyUXnNeQ-Nc7fvTuZtIhypUJSluLg3ZTkJVoGsop_y9IBWNlmmAC6Q68H43X_e8eKMhtQvKfhJLn5Xz51K509-CYI0nAqxnAoND2HgdlwgMnRAGCi8SJv4orE-9jiB6N3dvCh53TDL3zK1w7bzsZcWOd_1Wu2Gd__4d9qdHGpUKv5bWbfPoaYU_xO0NszrA</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Jonsson, Maria K.</creator><creator>Levi, Michael</creator><creator>Rudén, Ulla</creator><creator>Wahren, Britta</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>2006</creationdate><title>Minimal change in HSV-2 seroreactivity: A cross-sectional Swedish population study</title><author>Jonsson, Maria K. ; Levi, Michael ; Rudén, Ulla ; Wahren, Britta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-60a9a1f422daa052cce0a91254f007e197b15caa3f59d192f2141f4db41bc5cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Female</topic><topic>Herpes Genitalis - epidemiology</topic><topic>Herpes Genitalis - transmission</topic><topic>Herpes Simplex - epidemiology</topic><topic>Herpes Simplex - transmission</topic><topic>Herpes simplex virus 1</topic><topic>Herpes simplex virus 2</topic><topic>Herpesvirus 1, Human - immunology</topic><topic>Herpesvirus 2, Human - immunology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Seroepidemiologic Studies</topic><topic>Sex Factors</topic><topic>Sweden - epidemiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Jonsson, Maria K.</creatorcontrib><creatorcontrib>Levi, Michael</creatorcontrib><creatorcontrib>Rudén, Ulla</creatorcontrib><creatorcontrib>Wahren, Britta</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Scandinavian journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jonsson, Maria K.</au><au>Levi, Michael</au><au>Rudén, Ulla</au><au>Wahren, Britta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minimal change in HSV-2 seroreactivity: A cross-sectional Swedish population study</atitle><jtitle>Scandinavian journal of infectious diseases</jtitle><addtitle>Scand J Infect Dis</addtitle><date>2006</date><risdate>2006</risdate><volume>38</volume><issue>5</issue><spage>357</spage><epage>365</epage><pages>357-365</pages><artnum>357</artnum><issn>0036-5548</issn><eissn>1651-1980</eissn><coden>SJIDB7</coden><abstract>The prevalence of antibodies to herpes simplex virus type 2 (HSV-2) was determined in sera collected from 2 Swedish cross-sectional populations during 1990/91 and 1996/97. A glycoprotein G2 (gG-2) peptide ELISA was used to analyse 2899 sera from adults. We found a prevalence of 13.0% in 18-70-y-olds in 1990/91 and 16.4% in 31-55-y-olds in 1996/97. Seropositivity to HSV-2 was somewhat higher in women than in men; 14.4% compared to 11.6% in 1990/91 and 18.9% compared to 13.6% in 1996/97. Overall there was a significant difference in female prevalence of HSV-2 compared to prevalence in males of the same age groups (p=0.013). Total antibody prevalence to HSV-1 of 88% in HSV-2 negative individuals above 18 y of age was found. HSV-2 positive individuals were found seropositive to HSV-1 in approximately 95% of the cases. 12% were negative for both HSV-1 and HSV-2 antibodies. In addition, there was no serological sign that the reported increase of HSV-1 as an early sexual disease had reduced the frequency of HSV-2 seropositivity in the sexually most active age groups. 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| ispartof | Scandinavian journal of infectious diseases, 2006, Vol.38 (5), p.357-365, Article 357 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adolescent Adult Aged Antibodies, Viral - blood Biological and medical sciences Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay - methods Female Herpes Genitalis - epidemiology Herpes Genitalis - transmission Herpes Simplex - epidemiology Herpes Simplex - transmission Herpes simplex virus 1 Herpes simplex virus 2 Herpesvirus 1, Human - immunology Herpesvirus 2, Human - immunology Humans Infectious diseases Male Medical sciences Middle Aged Seroepidemiologic Studies Sex Factors Sweden - epidemiology |
| title | Minimal change in HSV-2 seroreactivity: A cross-sectional Swedish population study |
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