Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat
1 Schwartz Center for Metabolism and Nutrition, and Departments of 2 Medicine, 3 Physiology, 4 Nutrition, and 5 Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio Submitted 20 October 2005 ; accepted in final form 16 December 2005 Exercise improves glucose meta...
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| creator | O'Leary, Valerie B Marchetti, Christine M Krishnan, Raj K Stetzer, Bradley P Gonzalez, Frank Kirwan, John P |
| description | 1 Schwartz Center for Metabolism and Nutrition, and Departments of 2 Medicine, 3 Physiology, 4 Nutrition, and 5 Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio
Submitted 20 October 2005
; accepted in final form 16 December 2005
Exercise improves glucose metabolism and delays the onset and/or reverses insulin resistance in the elderly by an unknown mechanism. In the present study, we examined the effects of exercise training on glucose metabolism, abdominal adiposity, and adipocytokines in obese elderly. Sixteen obese men and women (age = 63 ± 1 yr, body mass index = 33.2 ± 1.4 kg/m 2 ) participated in a 12-wk supervised exercise program (5 days/wk, 60 min/day, treadmill/cycle ergometry at 85% of heart rate maximum). Visceral fat (VF), subcutaneous fat, and total abdominal fat were measured by computed tomography. Fat mass and fat-free mass were assessed by hydrostatic weighing. An oral glucose tolerance test was used to determine changes in insulin resistance. Exercise training increased maximal oxygen consumption (21.3 ± 0.8 vs. 24.3 ± 1.0 ml·kg 1 ·min 1 , P < 0.0001), decreased body weight ( P < 0.0001) and fat mass ( P < 0.001), while fat-free mass was not altered ( P > 0.05). VF (176 ± 20 vs. 136 ± 17 cm 2 , P < 0.0001), subcutaneous fat (351 ± 34 vs. 305 ± 28 cm 2 , P < 0.03), and total abdominal fat (525 ± 40 vs. 443 ± 34 cm 2 , P < 0.003) were reduced through training. Circulating leptin was lower ( P < 0.003) after training, but total adiponectin and tumor necrosis factor- remained unchanged. Insulin resistance was reversed by exercise (40.1 ± 7.7 vs. 27.6 ± 5.6 units, P < 0.01) and correlated with changes in VF ( r = 0.66, P < 0.01) and maximal oxygen consumption ( r = 0.48, P < 0.05) but not adipocytokines. VF loss after aerobic exercise training improves glucose metabolism and is associated with the reversal of insulin resistance in older obese men and women.
diabetes; obesity; aging; abdominal adiposity
Address for reprint requests and other correspondence: J. P. Kirwan, Schwartz Center for Metabolism and Nutrition, Case Western Reserve Univ. School of Medicine at MetroHealth Medical Center, Rm. G-733B, Bell Greve Bldg., 2500 MetroHealth Dr., Cleveland, OH 441091998 (e-mail: jpk10{at}case.edu ) |
| doi_str_mv | 10.1152/japplphysiol.01336.2005 |
| format | Article |
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Submitted 20 October 2005
; accepted in final form 16 December 2005
Exercise improves glucose metabolism and delays the onset and/or reverses insulin resistance in the elderly by an unknown mechanism. In the present study, we examined the effects of exercise training on glucose metabolism, abdominal adiposity, and adipocytokines in obese elderly. Sixteen obese men and women (age = 63 ± 1 yr, body mass index = 33.2 ± 1.4 kg/m 2 ) participated in a 12-wk supervised exercise program (5 days/wk, 60 min/day, treadmill/cycle ergometry at 85% of heart rate maximum). Visceral fat (VF), subcutaneous fat, and total abdominal fat were measured by computed tomography. Fat mass and fat-free mass were assessed by hydrostatic weighing. An oral glucose tolerance test was used to determine changes in insulin resistance. Exercise training increased maximal oxygen consumption (21.3 ± 0.8 vs. 24.3 ± 1.0 ml·kg 1 ·min 1 , P < 0.0001), decreased body weight ( P < 0.0001) and fat mass ( P < 0.001), while fat-free mass was not altered ( P > 0.05). VF (176 ± 20 vs. 136 ± 17 cm 2 , P < 0.0001), subcutaneous fat (351 ± 34 vs. 305 ± 28 cm 2 , P < 0.03), and total abdominal fat (525 ± 40 vs. 443 ± 34 cm 2 , P < 0.003) were reduced through training. Circulating leptin was lower ( P < 0.003) after training, but total adiponectin and tumor necrosis factor- remained unchanged. Insulin resistance was reversed by exercise (40.1 ± 7.7 vs. 27.6 ± 5.6 units, P < 0.01) and correlated with changes in VF ( r = 0.66, P < 0.01) and maximal oxygen consumption ( r = 0.48, P < 0.05) but not adipocytokines. VF loss after aerobic exercise training improves glucose metabolism and is associated with the reversal of insulin resistance in older obese men and women.
diabetes; obesity; aging; abdominal adiposity
Address for reprint requests and other correspondence: J. P. Kirwan, Schwartz Center for Metabolism and Nutrition, Case Western Reserve Univ. School of Medicine at MetroHealth Medical Center, Rm. G-733B, Bell Greve Bldg., 2500 MetroHealth Dr., Cleveland, OH 441091998 (e-mail: jpk10{at}case.edu )]]></description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.01336.2005</identifier><identifier>PMID: 16373444</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adiposity - physiology ; Age Factors ; Aging ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetes ; Exercise ; Exercise - physiology ; Exercise Test ; Exercise Therapy ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose Tolerance Test ; Humans ; Insulin ; Insulin Resistance - physiology ; Intra-Abdominal Fat - chemistry ; Leptin - blood ; Male ; Metabolism ; Middle Aged ; Obesity ; Obesity - pathology ; Obesity - physiopathology ; Older people ; Oxygen Consumption - physiology ; Triglycerides - blood ; Weight Loss</subject><ispartof>Journal of applied physiology (1985), 2006-05, Vol.100 (5), p.1584-1589</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright American Physiological Society May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-636c86e140f6f1cdeea17cf3ada08cd30992a3cb3224224037b73e2f259ca35c3</citedby><cites>FETCH-LOGICAL-c583t-636c86e140f6f1cdeea17cf3ada08cd30992a3cb3224224037b73e2f259ca35c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,3026,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17729617$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16373444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Leary, Valerie B</creatorcontrib><creatorcontrib>Marchetti, Christine M</creatorcontrib><creatorcontrib>Krishnan, Raj K</creatorcontrib><creatorcontrib>Stetzer, Bradley P</creatorcontrib><creatorcontrib>Gonzalez, Frank</creatorcontrib><creatorcontrib>Kirwan, John P</creatorcontrib><title>Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description><![CDATA[1 Schwartz Center for Metabolism and Nutrition, and Departments of 2 Medicine, 3 Physiology, 4 Nutrition, and 5 Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio
Submitted 20 October 2005
; accepted in final form 16 December 2005
Exercise improves glucose metabolism and delays the onset and/or reverses insulin resistance in the elderly by an unknown mechanism. In the present study, we examined the effects of exercise training on glucose metabolism, abdominal adiposity, and adipocytokines in obese elderly. Sixteen obese men and women (age = 63 ± 1 yr, body mass index = 33.2 ± 1.4 kg/m 2 ) participated in a 12-wk supervised exercise program (5 days/wk, 60 min/day, treadmill/cycle ergometry at 85% of heart rate maximum). Visceral fat (VF), subcutaneous fat, and total abdominal fat were measured by computed tomography. Fat mass and fat-free mass were assessed by hydrostatic weighing. An oral glucose tolerance test was used to determine changes in insulin resistance. Exercise training increased maximal oxygen consumption (21.3 ± 0.8 vs. 24.3 ± 1.0 ml·kg 1 ·min 1 , P < 0.0001), decreased body weight ( P < 0.0001) and fat mass ( P < 0.001), while fat-free mass was not altered ( P > 0.05). VF (176 ± 20 vs. 136 ± 17 cm 2 , P < 0.0001), subcutaneous fat (351 ± 34 vs. 305 ± 28 cm 2 , P < 0.03), and total abdominal fat (525 ± 40 vs. 443 ± 34 cm 2 , P < 0.003) were reduced through training. Circulating leptin was lower ( P < 0.003) after training, but total adiponectin and tumor necrosis factor- remained unchanged. Insulin resistance was reversed by exercise (40.1 ± 7.7 vs. 27.6 ± 5.6 units, P < 0.01) and correlated with changes in VF ( r = 0.66, P < 0.01) and maximal oxygen consumption ( r = 0.48, P < 0.05) but not adipocytokines. VF loss after aerobic exercise training improves glucose metabolism and is associated with the reversal of insulin resistance in older obese men and women.
diabetes; obesity; aging; abdominal adiposity
Address for reprint requests and other correspondence: J. P. Kirwan, Schwartz Center for Metabolism and Nutrition, Case Western Reserve Univ. School of Medicine at MetroHealth Medical Center, Rm. G-733B, Bell Greve Bldg., 2500 MetroHealth Dr., Cleveland, OH 441091998 (e-mail: jpk10{at}case.edu )]]></description><subject>Adiposity - physiology</subject><subject>Age Factors</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance - physiology</subject><subject>Intra-Abdominal Fat - chemistry</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - pathology</subject><subject>Obesity - physiopathology</subject><subject>Older people</subject><subject>Oxygen Consumption - physiology</subject><subject>Triglycerides - blood</subject><subject>Weight Loss</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVGL1DAUhYso7uzqX9AiKPjQMTdpkvZlQZZdFRZ8WZ9DJr2dZsg0NWlnd_69mZ3irIIIgcC93zm5NyfL3gJZAnD6aaOHwQ3dPlrvlgQYE0tKCH-WLVKXFiAIPM8WleSkkLySZ9l5jBtCoCw5vMzOQDDJyrJcZN31AwZjIxa2byaDTR5whyFql_s2t32cnO1TLdo46t5gKuV-hRFzdA0Gt89tzHWM3lg9JvW9HbuEH612NhoMyarV46vsRatdxNfzfZH9uLm-u_pa3H7_8u3q821heMXGQjBhKoFQkla0YBpEDdK0TDeaVKZhpK6pZmbFKC3TIUyuJEPaUl4bzbhhF9nl0XeYVltsDPZjmkANwW512Cuvrfqz09tOrf1OyeQlapYMPswGwf-cMI5qe1jDOd2jn6ISshIc-P9BkMCh5jKB7_4CN34KffoFRSmFqi4BEiSPkAk-xoDt75GBqEPm6mnm6jFzdcg8Kd883fikm0NOwPsZ0NFo14YUpI0nTkpaCzjMyY9cZ9fdvQ2o5tf8eq9uJufu8GE8jAGEKK6AV6UamjbpPv5bl3B14tkvDEHc5Q</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>O'Leary, Valerie B</creator><creator>Marchetti, Christine M</creator><creator>Krishnan, Raj K</creator><creator>Stetzer, Bradley P</creator><creator>Gonzalez, Frank</creator><creator>Kirwan, John P</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060501</creationdate><title>Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat</title><author>O'Leary, Valerie B ; Marchetti, Christine M ; Krishnan, Raj K ; Stetzer, Bradley P ; Gonzalez, Frank ; Kirwan, John P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-636c86e140f6f1cdeea17cf3ada08cd30992a3cb3224224037b73e2f259ca35c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adiposity - physiology</topic><topic>Age Factors</topic><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance - physiology</topic><topic>Intra-Abdominal Fat - chemistry</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - pathology</topic><topic>Obesity - physiopathology</topic><topic>Older people</topic><topic>Oxygen Consumption - physiology</topic><topic>Triglycerides - blood</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Leary, Valerie B</creatorcontrib><creatorcontrib>Marchetti, Christine M</creatorcontrib><creatorcontrib>Krishnan, Raj K</creatorcontrib><creatorcontrib>Stetzer, Bradley P</creatorcontrib><creatorcontrib>Gonzalez, Frank</creatorcontrib><creatorcontrib>Kirwan, John P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Leary, Valerie B</au><au>Marchetti, Christine M</au><au>Krishnan, Raj K</au><au>Stetzer, Bradley P</au><au>Gonzalez, Frank</au><au>Kirwan, John P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>100</volume><issue>5</issue><spage>1584</spage><epage>1589</epage><pages>1584-1589</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract><![CDATA[1 Schwartz Center for Metabolism and Nutrition, and Departments of 2 Medicine, 3 Physiology, 4 Nutrition, and 5 Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio
Submitted 20 October 2005
; accepted in final form 16 December 2005
Exercise improves glucose metabolism and delays the onset and/or reverses insulin resistance in the elderly by an unknown mechanism. In the present study, we examined the effects of exercise training on glucose metabolism, abdominal adiposity, and adipocytokines in obese elderly. Sixteen obese men and women (age = 63 ± 1 yr, body mass index = 33.2 ± 1.4 kg/m 2 ) participated in a 12-wk supervised exercise program (5 days/wk, 60 min/day, treadmill/cycle ergometry at 85% of heart rate maximum). Visceral fat (VF), subcutaneous fat, and total abdominal fat were measured by computed tomography. Fat mass and fat-free mass were assessed by hydrostatic weighing. An oral glucose tolerance test was used to determine changes in insulin resistance. Exercise training increased maximal oxygen consumption (21.3 ± 0.8 vs. 24.3 ± 1.0 ml·kg 1 ·min 1 , P < 0.0001), decreased body weight ( P < 0.0001) and fat mass ( P < 0.001), while fat-free mass was not altered ( P > 0.05). VF (176 ± 20 vs. 136 ± 17 cm 2 , P < 0.0001), subcutaneous fat (351 ± 34 vs. 305 ± 28 cm 2 , P < 0.03), and total abdominal fat (525 ± 40 vs. 443 ± 34 cm 2 , P < 0.003) were reduced through training. Circulating leptin was lower ( P < 0.003) after training, but total adiponectin and tumor necrosis factor- remained unchanged. Insulin resistance was reversed by exercise (40.1 ± 7.7 vs. 27.6 ± 5.6 units, P < 0.01) and correlated with changes in VF ( r = 0.66, P < 0.01) and maximal oxygen consumption ( r = 0.48, P < 0.05) but not adipocytokines. VF loss after aerobic exercise training improves glucose metabolism and is associated with the reversal of insulin resistance in older obese men and women.
diabetes; obesity; aging; abdominal adiposity
Address for reprint requests and other correspondence: J. P. Kirwan, Schwartz Center for Metabolism and Nutrition, Case Western Reserve Univ. School of Medicine at MetroHealth Medical Center, Rm. G-733B, Bell Greve Bldg., 2500 MetroHealth Dr., Cleveland, OH 441091998 (e-mail: jpk10{at}case.edu )]]></abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>16373444</pmid><doi>10.1152/japplphysiol.01336.2005</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adiposity - physiology Age Factors Aging Biological and medical sciences Blood Glucose - metabolism Diabetes Exercise Exercise - physiology Exercise Test Exercise Therapy Female Fundamental and applied biological sciences. Psychology Glucose Tolerance Test Humans Insulin Insulin Resistance - physiology Intra-Abdominal Fat - chemistry Leptin - blood Male Metabolism Middle Aged Obesity Obesity - pathology Obesity - physiopathology Older people Oxygen Consumption - physiology Triglycerides - blood Weight Loss |
| title | Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat |
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