Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia
Division of Pulmonary and Critical Care Medicine, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040 We sought to determine whether chronic exposure to intermittent hypoxia (CIH) increases sympathetic responsiveness to sub...
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| Veröffentlicht in: | Journal of applied physiology (1985) 1999-01, Vol.86 (1), p.298-305 |
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| creator | Greenberg, Harly E Sica, Anthony Batson, Deirdre Scharf, Steven M |
| description | Division of Pulmonary and Critical Care Medicine, Long Island Jewish
Medical Center, Long Island Campus for the Albert Einstein College of
Medicine, New Hyde Park, New York 11040
We sought to determine whether chronic exposure to
intermittent hypoxia (CIH) increases sympathetic responsiveness to
subsequent chemoreflex stimulation. Sprague-Dawley rats were exposed to
30 days of CIH: exposure chamber
%O 2 [fractional
concentration of chamber O 2
(Fc O 2 )]
nadir 6.5-7% with return to 21% each minute for 8 h/day during
the diurnal sleep period (Exp group). Sham controls (SC group) were
similarly handled but kept at 21%
Fc O 2 and
compared with unhandled controls (UC group). Rats were then anesthetized with urethan, and preganglionic cervical sympathetic activity (CSA), diaphragm electromyogram, arterial pressure, and electrocardiogram were recorded while the rats were spontaneously breathing 100% O 2 , room air, 10%
O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 . CSA and heart rate were also
recorded during phenylephrine infusion to assess baroreceptor function.
Mean arterial pressure was significantly greater in Exp than in SC and
UC rats during all conditions ( P |
| doi_str_mv | 10.1152/jappl.1999.86.1.298 |
| format | Article |
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Medical Center, Long Island Campus for the Albert Einstein College of
Medicine, New Hyde Park, New York 11040
We sought to determine whether chronic exposure to
intermittent hypoxia (CIH) increases sympathetic responsiveness to
subsequent chemoreflex stimulation. Sprague-Dawley rats were exposed to
30 days of CIH: exposure chamber
%O 2 [fractional
concentration of chamber O 2
(Fc O 2 )]
nadir 6.5-7% with return to 21% each minute for 8 h/day during
the diurnal sleep period (Exp group). Sham controls (SC group) were
similarly handled but kept at 21%
Fc O 2 and
compared with unhandled controls (UC group). Rats were then anesthetized with urethan, and preganglionic cervical sympathetic activity (CSA), diaphragm electromyogram, arterial pressure, and electrocardiogram were recorded while the rats were spontaneously breathing 100% O 2 , room air, 10%
O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 . CSA and heart rate were also
recorded during phenylephrine infusion to assess baroreceptor function.
Mean arterial pressure was significantly greater in Exp than in SC and
UC rats during all conditions ( P < 0.05). A vasopressor response to 10%
O 2 -12%
CO 2 was observed only in Exp rats.
CSA was greater in Exp than in SC and UC rats during 10%
O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 but not during room-air exposure. A significant increase in CSA compared with room air was
noted during 10% O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 in Exp but not in SC or UC
rats. No differences in baroreceptor function were observed among
groups. We conclude that CIH leads to increased sympathetic
responsiveness to chemoreflex stimulation.
sympathetic nervous system; intermittent hypoxia; chemoreflex; sleep apnea</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1999.86.1.298</identifier><identifier>PMID: 9887143</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Anatomy & physiology ; Animals ; Biological and medical sciences ; Blood Gas Analysis ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Electromyography ; Fundamental and applied biological sciences. Psychology ; Heart Rate - physiology ; Hypercapnia - physiopathology ; Hypoxia - physiopathology ; Male ; Nervous system ; Oxygen ; Pressoreceptors - physiology ; Rats ; Rats, Sprague-Dawley ; Reflex - physiology ; Sleep Apnea Syndromes - physiopathology ; Sleep disorders ; Space life sciences ; Sympathetic Nervous System - physiology ; Vertebrates: respiratory system</subject><ispartof>Journal of applied physiology (1985), 1999-01, Vol.86 (1), p.298-305</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Physiological Society Jan 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-b83e6de8b9aeb3df854b4d951536058e4b9b405bd41d75e8a69e64a1193809443</citedby><cites>FETCH-LOGICAL-c498t-b83e6de8b9aeb3df854b4d951536058e4b9b405bd41d75e8a69e64a1193809443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1688365$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9887143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greenberg, Harly E</creatorcontrib><creatorcontrib>Sica, Anthony</creatorcontrib><creatorcontrib>Batson, Deirdre</creatorcontrib><creatorcontrib>Scharf, Steven M</creatorcontrib><title>Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Division of Pulmonary and Critical Care Medicine, Long Island Jewish
Medical Center, Long Island Campus for the Albert Einstein College of
Medicine, New Hyde Park, New York 11040
We sought to determine whether chronic exposure to
intermittent hypoxia (CIH) increases sympathetic responsiveness to
subsequent chemoreflex stimulation. Sprague-Dawley rats were exposed to
30 days of CIH: exposure chamber
%O 2 [fractional
concentration of chamber O 2
(Fc O 2 )]
nadir 6.5-7% with return to 21% each minute for 8 h/day during
the diurnal sleep period (Exp group). Sham controls (SC group) were
similarly handled but kept at 21%
Fc O 2 and
compared with unhandled controls (UC group). Rats were then anesthetized with urethan, and preganglionic cervical sympathetic activity (CSA), diaphragm electromyogram, arterial pressure, and electrocardiogram were recorded while the rats were spontaneously breathing 100% O 2 , room air, 10%
O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 . CSA and heart rate were also
recorded during phenylephrine infusion to assess baroreceptor function.
Mean arterial pressure was significantly greater in Exp than in SC and
UC rats during all conditions ( P < 0.05). A vasopressor response to 10%
O 2 -12%
CO 2 was observed only in Exp rats.
CSA was greater in Exp than in SC and UC rats during 10%
O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 but not during room-air exposure. A significant increase in CSA compared with room air was
noted during 10% O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 in Exp but not in SC or UC
rats. No differences in baroreceptor function were observed among
groups. We conclude that CIH leads to increased sympathetic
responsiveness to chemoreflex stimulation.
sympathetic nervous system; intermittent hypoxia; chemoreflex; sleep apnea</description><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Gas Analysis</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Electromyography</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - physiology</subject><subject>Hypercapnia - physiopathology</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Nervous system</subject><subject>Oxygen</subject><subject>Pressoreceptors - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reflex - physiology</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><subject>Sleep disorders</subject><subject>Space life sciences</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vertebrates: respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kFGL1DAQx4N4nOvpJxBhEdGn1qRN0uRRFk-FA1_ONyGk7fSapU1ikur125u9W2_h4J4yZH7_meGH0BuCS0JY9WmvvZ9KIqUsBS9JWUnxDG1ypyoIx-Q52oiG4aJhonmBXsa4x5hQysg5OpdCNITWG_RrNwZnTbc1NkGYTUpg03Zcvbs1On92AXSEuI3r7HUaIWU0QPTORvMHLMS4Te6B17Y_1BA67a3Rr9DZoKcIr4_vBfp5-eV69624-vH1--7zVdFRKVLRihp4D6KVGtq6HwSjLe0lI6zmmAmgrWwpZm1PSd8wEJpL4FQTImuBJaX1BfpwP9cH93uBmNRsYgfTpC24JSouGWsayjP47hG4d0uw-TZVVVU2l11lqL6HuuBiDDAoH8ysw6oIVgfx6k68OohXgiuisvicenscvbQz9A-Zo-ncf3_s69jpaQjadiaeRnMhas5Oy0dzM_41AZQf12jc5G5WdblM0zXcpsMB_xcr3w859fHpVIZPZ_4DRwivQA</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Greenberg, Harly E</creator><creator>Sica, Anthony</creator><creator>Batson, Deirdre</creator><creator>Scharf, Steven M</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia</title><author>Greenberg, Harly E ; Sica, Anthony ; Batson, Deirdre ; Scharf, Steven M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-b83e6de8b9aeb3df854b4d951536058e4b9b405bd41d75e8a69e64a1193809443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Gas Analysis</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Electromyography</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - physiology</topic><topic>Hypercapnia - physiopathology</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Nervous system</topic><topic>Oxygen</topic><topic>Pressoreceptors - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reflex - physiology</topic><topic>Sleep Apnea Syndromes - physiopathology</topic><topic>Sleep disorders</topic><topic>Space life sciences</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenberg, Harly E</creatorcontrib><creatorcontrib>Sica, Anthony</creatorcontrib><creatorcontrib>Batson, Deirdre</creatorcontrib><creatorcontrib>Scharf, Steven M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenberg, Harly E</au><au>Sica, Anthony</au><au>Batson, Deirdre</au><au>Scharf, Steven M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>86</volume><issue>1</issue><spage>298</spage><epage>305</epage><pages>298-305</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Division of Pulmonary and Critical Care Medicine, Long Island Jewish
Medical Center, Long Island Campus for the Albert Einstein College of
Medicine, New Hyde Park, New York 11040
We sought to determine whether chronic exposure to
intermittent hypoxia (CIH) increases sympathetic responsiveness to
subsequent chemoreflex stimulation. Sprague-Dawley rats were exposed to
30 days of CIH: exposure chamber
%O 2 [fractional
concentration of chamber O 2
(Fc O 2 )]
nadir 6.5-7% with return to 21% each minute for 8 h/day during
the diurnal sleep period (Exp group). Sham controls (SC group) were
similarly handled but kept at 21%
Fc O 2 and
compared with unhandled controls (UC group). Rats were then anesthetized with urethan, and preganglionic cervical sympathetic activity (CSA), diaphragm electromyogram, arterial pressure, and electrocardiogram were recorded while the rats were spontaneously breathing 100% O 2 , room air, 10%
O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 . CSA and heart rate were also
recorded during phenylephrine infusion to assess baroreceptor function.
Mean arterial pressure was significantly greater in Exp than in SC and
UC rats during all conditions ( P < 0.05). A vasopressor response to 10%
O 2 -12%
CO 2 was observed only in Exp rats.
CSA was greater in Exp than in SC and UC rats during 10%
O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 but not during room-air exposure. A significant increase in CSA compared with room air was
noted during 10% O 2 , 12%
CO 2 , and 10%
O 2 -12%
CO 2 in Exp but not in SC or UC
rats. No differences in baroreceptor function were observed among
groups. We conclude that CIH leads to increased sympathetic
responsiveness to chemoreflex stimulation.
sympathetic nervous system; intermittent hypoxia; chemoreflex; sleep apnea</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9887143</pmid><doi>10.1152/jappl.1999.86.1.298</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1999-01, Vol.86 (1), p.298-305 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_1688365 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anatomy & physiology Animals Biological and medical sciences Blood Gas Analysis Cardiorespiratory control. Arterial mecano- and chemoreceptor Electromyography Fundamental and applied biological sciences. Psychology Heart Rate - physiology Hypercapnia - physiopathology Hypoxia - physiopathology Male Nervous system Oxygen Pressoreceptors - physiology Rats Rats, Sprague-Dawley Reflex - physiology Sleep Apnea Syndromes - physiopathology Sleep disorders Space life sciences Sympathetic Nervous System - physiology Vertebrates: respiratory system |
| title | Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia |
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