An objective function for radiation treatment optimization based on local biological measures

The implementation of biological optimization of radiation treatment plans is impeded by both computational and modelling problems. We derive an objective function from basic model assumptions which includes the normal tissue constraints as interior penalty functions. For organs that are composed of...

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Veröffentlicht in:	Physics in medicine & biology 1999-02, Vol.44 (2), p.479-493
Hauptverfasser:	Alber, M, Nüsslin, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Humans Medical sciences Miscellaneous Models, Biological Neoplasms - radiotherapy Poisson Distribution Radiation Dosage Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Scattering, Radiation
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