Dual Effects of Anti-inflammatory 2-Arylpropionic Acid Derivatives on a Major Isoform of Human Liver 3α-Hydroxysteroid Dehydrogenase

Nonsteroidal anti-inflammatory drugs have been shown to be potent inhibitors of mammalian 3α-hydroxy-steroid dehydrogenase. Here, we report that the drugs of the 2-arylpropionic acid class act as both activators and inhibitors for a predominant isoform of the human liver enzyme which is involved in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biological & pharmaceutical bulletin 1998/11/15, Vol.21(11), pp.1148-1153
Hauptverfasser:	YAMAMOTO, Tomohiro, MATSUURA, Kazuya, SHINTANI, Shunichi, HARA, Akira, MIYABE, Yoshiyuki, SUGIYAMA, Tadashi, KATAGIRI, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	3α-hydroxysteroid dehydrogenase activation aldo-keto reductase family anti-inflammatory drug Biological and medical sciences Drug toxicity and drugs side effects treatment Medical sciences Pharmacology. Drug treatments stereoselectivity Toxicity: digestive system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!