Discovery of a New Series of Centrally Active Tricyclic Isoxazoles Combining Serotonin (5-HT) Reuptake Inhibition with α2-Adrenoceptor Blocking Activity

The synthesis and pharmacology of a new series of 3-piperazinylmethyl-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles that combine central serotonin (5-HT) reuptake inhibition with α2-adrenoceptor blocking activity is described as potential antidepressants. Four compounds were selected for further e...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-03, Vol.48 (6), p.2054-2071
Hauptverfasser:	Andrés, J. Ignacio, Alcázar, Jesús, Alonso, José M, Alvarez, Rosa M, Bakker, Margot H, Biesmans, Ilse, Cid, José M, De Lucas, Ana I, Fernández, Javier, Font, Luis M, Hens, Koen A, Iturrino, Laura, Lenaerts, Ilse, Martínez, Sonia, Megens, Anton A, Pastor, Joaquín, Vermote, Patrick C. M, Steckler, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology
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