Prevention of impulse noise-induced hearing loss with antioxidants
Conclusion These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury. Objective Reactive oxygen species have been shown to...
Gespeichert in:
| Veröffentlicht in: | Acta oto-laryngologica 2005-03, Vol.125 (3), p.235-243 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 243 |
|---|---|
| container_issue | 3 |
| container_start_page | 235 |
| container_title | Acta oto-laryngologica |
| container_volume | 125 |
| creator | Kopke, Richard Bielefeld, Eric Liu, Jianzhong Zheng, Jiefu Jackson, Ronald Henderson, Donald Coleman, John K. M. |
| description | Conclusion
These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury.
Objective
Reactive oxygen species have been shown to play a significant role in noise-induced hearing loss. In the current study, the protective effects of two antioxidants, acetyl-L-carnitine (ALCAR) and N-L-acetylcysteine (NAC), were investigated in a chinchilla model of hearing loss resulting from impulse noise. It was hypothesized that pre- and post-treatment with these antioxidants would ameliorate the effects of impulse noise compared to saline-treated controls.
Material and methods
Eighteen animals were randomly assigned to 1 of 3 groups and exposed to impulse noise at a level of 155 dB peak SPL for 150 repetitions. ALCAR or NAC were administered twice daily (b.i.d.) for 2 days and 1 h prior to and 1 h following noise exposure, and then b.i.d. for the following 2 days. For the control group, saline was injected at the same time points. Auditory brainstem responses (ABRs) were recorded. Cochlear surface preparations were made to obtain cytocochleograms.
Results
Three weeks after exposure, permanent threshold shifts for the experimental groups were significantly reduced to 10-30 dB less than that for the control group (p |
| doi_str_mv | 10.1080/00016480410023038 |
| format | Article |
| fullrecord | <record><control><sourceid>informahealthcare_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_16610937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1080_00016480410023038</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-81c1c0dc82bc98b6f41b30e9cf68a9a51af174acd0229b23e6ac93721b0de63a3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlZ_gBfZi8fVmWQ33aAXLX5BQQ96XrLZxKbsR0m21v57s7RSROhpCPM8w5uXkHOEK4QMrgEAeZJBggCUAcsOyBB5ijGlKR6SYb-PAyAG5MT7ef8UWXpMBpgKzrmAIbl_c_pLN51tm6g1ka0Xy8rrqGmt17FtyqXSZTTT0tnmM6pa76OV7WaR7I1vW4bpT8mRkUE6284R-Xh8eJ88x9PXp5fJ3TRWCUu6OEOFCkqV0UKJrOAmwYKBFsrwTAqZojQ4TqQqgVJRUKa5VIKNKRZQas4kGxHc3FUu5HDa5Atna-nWOULe95H_6yM4FxtnsSxqXe6MbQEBuNwC0itZGScbZf2O4xwhpAjc7YazjWldLVetq8q8k-uqdb8S25fj5o8eGq26mZJO5_N26ZrQ255f_ABWDI1b</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Prevention of impulse noise-induced hearing loss with antioxidants</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>Kopke, Richard ; Bielefeld, Eric ; Liu, Jianzhong ; Zheng, Jiefu ; Jackson, Ronald ; Henderson, Donald ; Coleman, John K. M.</creator><creatorcontrib>Kopke, Richard ; Bielefeld, Eric ; Liu, Jianzhong ; Zheng, Jiefu ; Jackson, Ronald ; Henderson, Donald ; Coleman, John K. M.</creatorcontrib><description>Conclusion
These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury.
Objective
Reactive oxygen species have been shown to play a significant role in noise-induced hearing loss. In the current study, the protective effects of two antioxidants, acetyl-L-carnitine (ALCAR) and N-L-acetylcysteine (NAC), were investigated in a chinchilla model of hearing loss resulting from impulse noise. It was hypothesized that pre- and post-treatment with these antioxidants would ameliorate the effects of impulse noise compared to saline-treated controls.
Material and methods
Eighteen animals were randomly assigned to 1 of 3 groups and exposed to impulse noise at a level of 155 dB peak SPL for 150 repetitions. ALCAR or NAC were administered twice daily (b.i.d.) for 2 days and 1 h prior to and 1 h following noise exposure, and then b.i.d. for the following 2 days. For the control group, saline was injected at the same time points. Auditory brainstem responses (ABRs) were recorded. Cochlear surface preparations were made to obtain cytocochleograms.
Results
Three weeks after exposure, permanent threshold shifts for the experimental groups were significantly reduced to 10-30 dB less than that for the control group (p<0.01). Less hair cell loss was also observed in the ALCAR and NAC groups than in the control group.</description><identifier>ISSN: 0001-6489</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.1080/00016480410023038</identifier><identifier>PMID: 15966690</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Acetylcarnitine - pharmacology ; Acetylcysteine - pharmacology ; Animals ; Antioxidant ; Antioxidants - pharmacology ; Biological and medical sciences ; Chinchilla ; Disease Models, Animal ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; evoked potential ; Evoked Potentials, Auditory, Brain Stem - drug effects ; Female ; hair cell ; Hair Cells, Auditory - drug effects ; Hair Cells, Auditory - pathology ; Hearing Loss, Noise-Induced - prevention & control ; impulse noise ; Medical sciences ; noise-induced hearing loss ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Recovery of Function - drug effects</subject><ispartof>Acta oto-laryngologica, 2005-03, Vol.125 (3), p.235-243</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-81c1c0dc82bc98b6f41b30e9cf68a9a51af174acd0229b23e6ac93721b0de63a3</citedby><cites>FETCH-LOGICAL-c434t-81c1c0dc82bc98b6f41b30e9cf68a9a51af174acd0229b23e6ac93721b0de63a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00016480410023038$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00016480410023038$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16610937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15966690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kopke, Richard</creatorcontrib><creatorcontrib>Bielefeld, Eric</creatorcontrib><creatorcontrib>Liu, Jianzhong</creatorcontrib><creatorcontrib>Zheng, Jiefu</creatorcontrib><creatorcontrib>Jackson, Ronald</creatorcontrib><creatorcontrib>Henderson, Donald</creatorcontrib><creatorcontrib>Coleman, John K. M.</creatorcontrib><title>Prevention of impulse noise-induced hearing loss with antioxidants</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>Conclusion
These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury.
Objective
Reactive oxygen species have been shown to play a significant role in noise-induced hearing loss. In the current study, the protective effects of two antioxidants, acetyl-L-carnitine (ALCAR) and N-L-acetylcysteine (NAC), were investigated in a chinchilla model of hearing loss resulting from impulse noise. It was hypothesized that pre- and post-treatment with these antioxidants would ameliorate the effects of impulse noise compared to saline-treated controls.
Material and methods
Eighteen animals were randomly assigned to 1 of 3 groups and exposed to impulse noise at a level of 155 dB peak SPL for 150 repetitions. ALCAR or NAC were administered twice daily (b.i.d.) for 2 days and 1 h prior to and 1 h following noise exposure, and then b.i.d. for the following 2 days. For the control group, saline was injected at the same time points. Auditory brainstem responses (ABRs) were recorded. Cochlear surface preparations were made to obtain cytocochleograms.
Results
Three weeks after exposure, permanent threshold shifts for the experimental groups were significantly reduced to 10-30 dB less than that for the control group (p<0.01). Less hair cell loss was also observed in the ALCAR and NAC groups than in the control group.</description><subject>Acetylcarnitine - pharmacology</subject><subject>Acetylcysteine - pharmacology</subject><subject>Animals</subject><subject>Antioxidant</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chinchilla</subject><subject>Disease Models, Animal</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>evoked potential</subject><subject>Evoked Potentials, Auditory, Brain Stem - drug effects</subject><subject>Female</subject><subject>hair cell</subject><subject>Hair Cells, Auditory - drug effects</subject><subject>Hair Cells, Auditory - pathology</subject><subject>Hearing Loss, Noise-Induced - prevention & control</subject><subject>impulse noise</subject><subject>Medical sciences</subject><subject>noise-induced hearing loss</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Recovery of Function - drug effects</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlZ_gBfZi8fVmWQ33aAXLX5BQQ96XrLZxKbsR0m21v57s7RSROhpCPM8w5uXkHOEK4QMrgEAeZJBggCUAcsOyBB5ijGlKR6SYb-PAyAG5MT7ef8UWXpMBpgKzrmAIbl_c_pLN51tm6g1ka0Xy8rrqGmt17FtyqXSZTTT0tnmM6pa76OV7WaR7I1vW4bpT8mRkUE6284R-Xh8eJ88x9PXp5fJ3TRWCUu6OEOFCkqV0UKJrOAmwYKBFsrwTAqZojQ4TqQqgVJRUKa5VIKNKRZQas4kGxHc3FUu5HDa5Atna-nWOULe95H_6yM4FxtnsSxqXe6MbQEBuNwC0itZGScbZf2O4xwhpAjc7YazjWldLVetq8q8k-uqdb8S25fj5o8eGq26mZJO5_N26ZrQ255f_ABWDI1b</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Kopke, Richard</creator><creator>Bielefeld, Eric</creator><creator>Liu, Jianzhong</creator><creator>Zheng, Jiefu</creator><creator>Jackson, Ronald</creator><creator>Henderson, Donald</creator><creator>Coleman, John K. M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20050301</creationdate><title>Prevention of impulse noise-induced hearing loss with antioxidants</title><author>Kopke, Richard ; Bielefeld, Eric ; Liu, Jianzhong ; Zheng, Jiefu ; Jackson, Ronald ; Henderson, Donald ; Coleman, John K. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-81c1c0dc82bc98b6f41b30e9cf68a9a51af174acd0229b23e6ac93721b0de63a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetylcarnitine - pharmacology</topic><topic>Acetylcysteine - pharmacology</topic><topic>Animals</topic><topic>Antioxidant</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chinchilla</topic><topic>Disease Models, Animal</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>evoked potential</topic><topic>Evoked Potentials, Auditory, Brain Stem - drug effects</topic><topic>Female</topic><topic>hair cell</topic><topic>Hair Cells, Auditory - drug effects</topic><topic>Hair Cells, Auditory - pathology</topic><topic>Hearing Loss, Noise-Induced - prevention & control</topic><topic>impulse noise</topic><topic>Medical sciences</topic><topic>noise-induced hearing loss</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Recovery of Function - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kopke, Richard</creatorcontrib><creatorcontrib>Bielefeld, Eric</creatorcontrib><creatorcontrib>Liu, Jianzhong</creatorcontrib><creatorcontrib>Zheng, Jiefu</creatorcontrib><creatorcontrib>Jackson, Ronald</creatorcontrib><creatorcontrib>Henderson, Donald</creatorcontrib><creatorcontrib>Coleman, John K. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kopke, Richard</au><au>Bielefeld, Eric</au><au>Liu, Jianzhong</au><au>Zheng, Jiefu</au><au>Jackson, Ronald</au><au>Henderson, Donald</au><au>Coleman, John K. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of impulse noise-induced hearing loss with antioxidants</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>125</volume><issue>3</issue><spage>235</spage><epage>243</epage><pages>235-243</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>Conclusion
These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury.
Objective
Reactive oxygen species have been shown to play a significant role in noise-induced hearing loss. In the current study, the protective effects of two antioxidants, acetyl-L-carnitine (ALCAR) and N-L-acetylcysteine (NAC), were investigated in a chinchilla model of hearing loss resulting from impulse noise. It was hypothesized that pre- and post-treatment with these antioxidants would ameliorate the effects of impulse noise compared to saline-treated controls.
Material and methods
Eighteen animals were randomly assigned to 1 of 3 groups and exposed to impulse noise at a level of 155 dB peak SPL for 150 repetitions. ALCAR or NAC were administered twice daily (b.i.d.) for 2 days and 1 h prior to and 1 h following noise exposure, and then b.i.d. for the following 2 days. For the control group, saline was injected at the same time points. Auditory brainstem responses (ABRs) were recorded. Cochlear surface preparations were made to obtain cytocochleograms.
Results
Three weeks after exposure, permanent threshold shifts for the experimental groups were significantly reduced to 10-30 dB less than that for the control group (p<0.01). Less hair cell loss was also observed in the ALCAR and NAC groups than in the control group.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>15966690</pmid><doi>10.1080/00016480410023038</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6489 |
| ispartof | Acta oto-laryngologica, 2005-03, Vol.125 (3), p.235-243 |
| issn | 0001-6489 1651-2251 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_16610937 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Acetylcarnitine - pharmacology Acetylcysteine - pharmacology Animals Antioxidant Antioxidants - pharmacology Biological and medical sciences Chinchilla Disease Models, Animal Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology evoked potential Evoked Potentials, Auditory, Brain Stem - drug effects Female hair cell Hair Cells, Auditory - drug effects Hair Cells, Auditory - pathology Hearing Loss, Noise-Induced - prevention & control impulse noise Medical sciences noise-induced hearing loss Non tumoral diseases Otorhinolaryngology. Stomatology Recovery of Function - drug effects |
| title | Prevention of impulse noise-induced hearing loss with antioxidants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T15%3A26%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-informahealthcare_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevention%20of%20impulse%20noise-induced%20hearing%20loss%20with%20antioxidants&rft.jtitle=Acta%20oto-laryngologica&rft.au=Kopke,%20Richard&rft.date=2005-03-01&rft.volume=125&rft.issue=3&rft.spage=235&rft.epage=243&rft.pages=235-243&rft.issn=0001-6489&rft.eissn=1651-2251&rft.coden=AOLAAJ&rft_id=info:doi/10.1080/00016480410023038&rft_dat=%3Cinformahealthcare_pasca%3E10_1080_00016480410023038%3C/informahealthcare_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/15966690&rfr_iscdi=true |