High Salt Diet Enhances Cardiovascular Responses from the Nucleus Tractus Solitarius and Ventrolateral Medulla of Sprague-Dawley Rats
High salt intake has been shown to augment the sensitivity of rostral ventrolateral medulla (RVLM) sympathoexcitatory neurons. We examined the effects of 4 weeks of high dietary salt (8%) on the sensitivity of nucleus tractus solitarius (NTS) and caudal ventrolateral medulla (CVLM) in controlling RV...
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| Veröffentlicht in: | Clinical and experimental hypertension (1993) 2005, Vol.27 (1), p.33-44 |
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| container_title | Clinical and experimental hypertension (1993) |
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| creator | Isogai, O Tsukamoto, Kazuyoshi Masubuchi, Y Tomioka, S Suzuki, T Kawato, H Yajima, Y Kasamaki, Y Ito, S Kanmatsuse, K |
| description | High salt intake has been shown to augment the sensitivity of rostral ventrolateral medulla (RVLM) sympathoexcitatory neurons. We examined the effects of 4 weeks of high dietary salt (8%) on the sensitivity of nucleus tractus solitarius (NTS) and caudal ventrolateral medulla (CVLM) in controlling RVLM. In chloralose-anesthetized Sprague-Dawley rats, high salt intake did not elevate baseline arterial pressure or heart rate (HR). In high-salt group, NTS, CVLM, and RVLM responses to glutamate were greater. NTS responses to acetylcholine or serotonin, which is independent of baroreflex, also were greater. Phenylephrine or nitroprusside (i.v.) elicited similar changes in arterial pressure and heart rate, the baroreflex sensitivity also was similar in both groups of rats. These results suggest that high salt intake augments the sensitivity of NTS and CVLM sending inhibitory input to RVLM. This presumably may inhibit the RVLM, thereby inhibiting the elevation of arterial pressure. |
| doi_str_mv | 10.1081/CEH-200044252 |
| format | Article |
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We examined the effects of 4 weeks of high dietary salt (8%) on the sensitivity of nucleus tractus solitarius (NTS) and caudal ventrolateral medulla (CVLM) in controlling RVLM. In chloralose-anesthetized Sprague-Dawley rats, high salt intake did not elevate baseline arterial pressure or heart rate (HR). In high-salt group, NTS, CVLM, and RVLM responses to glutamate were greater. NTS responses to acetylcholine or serotonin, which is independent of baroreflex, also were greater. Phenylephrine or nitroprusside (i.v.) elicited similar changes in arterial pressure and heart rate, the baroreflex sensitivity also was similar in both groups of rats. These results suggest that high salt intake augments the sensitivity of NTS and CVLM sending inhibitory input to RVLM. This presumably may inhibit the RVLM, thereby inhibiting the elevation of arterial pressure.</description><identifier>ISSN: 1064-1963</identifier><identifier>EISSN: 1525-6006</identifier><identifier>DOI: 10.1081/CEH-200044252</identifier><identifier>PMID: 15773228</identifier><identifier>CODEN: CEHYER</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Acetylcholine - pharmacology ; Acetylcholine - physiology ; Animals ; Arterial hypertension. Arterial hypotension ; Baroreflex - drug effects ; Baroreflex - physiology ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; CVLM ; Drug Synergism ; Experimental diseases ; Glutamic Acid - pharmacology ; Heart Rate - drug effects ; high salt ; Hypertension - physiopathology ; Male ; Medical sciences ; Medulla Oblongata - drug effects ; Medulla Oblongata - physiology ; Microinjections ; NTS ; Rats ; Rats, Sprague-Dawley ; RVLM ; Serotonin - pharmacology ; Serotonin - physiology ; Sodium Chloride, Dietary - pharmacology ; Solitary Nucleus - drug effects ; Solitary Nucleus - physiology</subject><ispartof>Clinical and experimental hypertension (1993), 2005, Vol.27 (1), p.33-44</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-faa8cf09bfe933e5b4f94d3931195ad29f77d10d4fdb7f50ce79cc358f59c1963</citedby><cites>FETCH-LOGICAL-c449t-faa8cf09bfe933e5b4f94d3931195ad29f77d10d4fdb7f50ce79cc358f59c1963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/CEH-200044252$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/CEH-200044252$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16541161$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15773228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Isogai, O</creatorcontrib><creatorcontrib>Tsukamoto, Kazuyoshi</creatorcontrib><creatorcontrib>Masubuchi, Y</creatorcontrib><creatorcontrib>Tomioka, S</creatorcontrib><creatorcontrib>Suzuki, T</creatorcontrib><creatorcontrib>Kawato, H</creatorcontrib><creatorcontrib>Yajima, Y</creatorcontrib><creatorcontrib>Kasamaki, Y</creatorcontrib><creatorcontrib>Ito, S</creatorcontrib><creatorcontrib>Kanmatsuse, K</creatorcontrib><title>High Salt Diet Enhances Cardiovascular Responses from the Nucleus Tractus Solitarius and Ventrolateral Medulla of Sprague-Dawley Rats</title><title>Clinical and experimental hypertension (1993)</title><addtitle>Clin Exp Hypertens</addtitle><description>High salt intake has been shown to augment the sensitivity of rostral ventrolateral medulla (RVLM) sympathoexcitatory neurons. We examined the effects of 4 weeks of high dietary salt (8%) on the sensitivity of nucleus tractus solitarius (NTS) and caudal ventrolateral medulla (CVLM) in controlling RVLM. In chloralose-anesthetized Sprague-Dawley rats, high salt intake did not elevate baseline arterial pressure or heart rate (HR). In high-salt group, NTS, CVLM, and RVLM responses to glutamate were greater. NTS responses to acetylcholine or serotonin, which is independent of baroreflex, also were greater. Phenylephrine or nitroprusside (i.v.) elicited similar changes in arterial pressure and heart rate, the baroreflex sensitivity also was similar in both groups of rats. These results suggest that high salt intake augments the sensitivity of NTS and CVLM sending inhibitory input to RVLM. This presumably may inhibit the RVLM, thereby inhibiting the elevation of arterial pressure.</description><subject>Acetylcholine - pharmacology</subject><subject>Acetylcholine - physiology</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Baroreflex - drug effects</subject><subject>Baroreflex - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>CVLM</subject><subject>Drug Synergism</subject><subject>Experimental diseases</subject><subject>Glutamic Acid - pharmacology</subject><subject>Heart Rate - drug effects</subject><subject>high salt</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medulla Oblongata - drug effects</subject><subject>Medulla Oblongata - physiology</subject><subject>Microinjections</subject><subject>NTS</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RVLM</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin - physiology</subject><subject>Sodium Chloride, Dietary - pharmacology</subject><subject>Solitary Nucleus - drug effects</subject><subject>Solitary Nucleus - physiology</subject><issn>1064-1963</issn><issn>1525-6006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhiMEoqVw5Ip8obeAndhJfETbhUUqIHUL12jWHjepvPEydqj2AXhvXO1CxaGnGWm-Gf36piheC_5O8E68XyxXZcU5l7JS1ZPiVKhKlQ3nzdPc80aWQjf1SfEixlvOhWxU97w4Eapt66rqTovfq_FmYGvwiV2MmNhyGmAyGNkCyI7hF0QzeyB2hXEXppgHjsKWpQHZ19l4nCO7JjAp13XwYwIacwuTZT9wShQ8JCTw7Ava2XtgwbH1juBmxvIC7jzu2RWk-LJ45sBHfHWsZ8X3j8vrxaq8_Pbp8-LDZWmk1Kl0AJ1xXG8c6rpGtZFOS1vrWgitwFbata0V3EpnN61T3GCrjalV55Q29x7OivPD3R2FnzPG1G_HaDAHmzDMsa-4qttGygyWB9BQiJHQ9Tsat0D7XvD-3nufvff_vGf-zfHwvNmifaCPojPw9ghko-AdZctjfOAaJYVoROa6AzdOLtAW7gJ52yfY-0B_l-rHMrT_rQ6YvzoYIOxvw0xTFvtI-j_zK7Eg</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Isogai, O</creator><creator>Tsukamoto, Kazuyoshi</creator><creator>Masubuchi, Y</creator><creator>Tomioka, S</creator><creator>Suzuki, T</creator><creator>Kawato, H</creator><creator>Yajima, Y</creator><creator>Kasamaki, Y</creator><creator>Ito, S</creator><creator>Kanmatsuse, K</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>2005</creationdate><title>High Salt Diet Enhances Cardiovascular Responses from the Nucleus Tractus Solitarius and Ventrolateral Medulla of Sprague-Dawley Rats</title><author>Isogai, O ; Tsukamoto, Kazuyoshi ; Masubuchi, Y ; Tomioka, S ; Suzuki, T ; Kawato, H ; Yajima, Y ; Kasamaki, Y ; Ito, S ; Kanmatsuse, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-faa8cf09bfe933e5b4f94d3931195ad29f77d10d4fdb7f50ce79cc358f59c1963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Acetylcholine - physiology</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Baroreflex - drug effects</topic><topic>Baroreflex - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>CVLM</topic><topic>Drug Synergism</topic><topic>Experimental diseases</topic><topic>Glutamic Acid - pharmacology</topic><topic>Heart Rate - drug effects</topic><topic>high salt</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medulla Oblongata - drug effects</topic><topic>Medulla Oblongata - physiology</topic><topic>Microinjections</topic><topic>NTS</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RVLM</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin - physiology</topic><topic>Sodium Chloride, Dietary - pharmacology</topic><topic>Solitary Nucleus - drug effects</topic><topic>Solitary Nucleus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Isogai, O</creatorcontrib><creatorcontrib>Tsukamoto, Kazuyoshi</creatorcontrib><creatorcontrib>Masubuchi, Y</creatorcontrib><creatorcontrib>Tomioka, S</creatorcontrib><creatorcontrib>Suzuki, T</creatorcontrib><creatorcontrib>Kawato, H</creatorcontrib><creatorcontrib>Yajima, Y</creatorcontrib><creatorcontrib>Kasamaki, Y</creatorcontrib><creatorcontrib>Ito, S</creatorcontrib><creatorcontrib>Kanmatsuse, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Clinical and experimental hypertension (1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Isogai, O</au><au>Tsukamoto, Kazuyoshi</au><au>Masubuchi, Y</au><au>Tomioka, S</au><au>Suzuki, T</au><au>Kawato, H</au><au>Yajima, Y</au><au>Kasamaki, Y</au><au>Ito, S</au><au>Kanmatsuse, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Salt Diet Enhances Cardiovascular Responses from the Nucleus Tractus Solitarius and Ventrolateral Medulla of Sprague-Dawley Rats</atitle><jtitle>Clinical and experimental hypertension (1993)</jtitle><addtitle>Clin Exp Hypertens</addtitle><date>2005</date><risdate>2005</risdate><volume>27</volume><issue>1</issue><spage>33</spage><epage>44</epage><pages>33-44</pages><issn>1064-1963</issn><eissn>1525-6006</eissn><coden>CEHYER</coden><abstract>High salt intake has been shown to augment the sensitivity of rostral ventrolateral medulla (RVLM) sympathoexcitatory neurons. We examined the effects of 4 weeks of high dietary salt (8%) on the sensitivity of nucleus tractus solitarius (NTS) and caudal ventrolateral medulla (CVLM) in controlling RVLM. In chloralose-anesthetized Sprague-Dawley rats, high salt intake did not elevate baseline arterial pressure or heart rate (HR). In high-salt group, NTS, CVLM, and RVLM responses to glutamate were greater. NTS responses to acetylcholine or serotonin, which is independent of baroreflex, also were greater. Phenylephrine or nitroprusside (i.v.) elicited similar changes in arterial pressure and heart rate, the baroreflex sensitivity also was similar in both groups of rats. These results suggest that high salt intake augments the sensitivity of NTS and CVLM sending inhibitory input to RVLM. This presumably may inhibit the RVLM, thereby inhibiting the elevation of arterial pressure.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>15773228</pmid><doi>10.1081/CEH-200044252</doi><tpages>12</tpages></addata></record> |
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| ispartof | Clinical and experimental hypertension (1993), 2005, Vol.27 (1), p.33-44 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Acetylcholine - pharmacology Acetylcholine - physiology Animals Arterial hypertension. Arterial hypotension Baroreflex - drug effects Baroreflex - physiology Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology CVLM Drug Synergism Experimental diseases Glutamic Acid - pharmacology Heart Rate - drug effects high salt Hypertension - physiopathology Male Medical sciences Medulla Oblongata - drug effects Medulla Oblongata - physiology Microinjections NTS Rats Rats, Sprague-Dawley RVLM Serotonin - pharmacology Serotonin - physiology Sodium Chloride, Dietary - pharmacology Solitary Nucleus - drug effects Solitary Nucleus - physiology |
| title | High Salt Diet Enhances Cardiovascular Responses from the Nucleus Tractus Solitarius and Ventrolateral Medulla of Sprague-Dawley Rats |
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