4,6-Disubstituted 2,2-Dimethylchromans Structurally Related to the KATP Channel Opener Cromakalim: Design, Synthesis, and Effect on Insulin Release and Vascular Tone

Five series (ureas, thioureas, carbamates, sulfonylureas, and amides) of 4,6-disubstituted-2,2-dimethylchromans structurally related to cromakalim were prepared and evaluated, as putative ATP-sensitive potassium channel activators, on rat pancreatic islets and rat aorta rings. The biological data in...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-01, Vol.48 (2), p.614-621
Hauptverfasser:	Sebille, Sophie, de Tullio, Pascal, Becker, Bénédicte, Antoine, Marie-Hélène, Boverie, Stéphane, Pirotte, Bernard, Lebrun, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Medical sciences Miscellaneous Pharmacology. Drug treatments
Online-Zugang:	Volltext
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