Acute Human Self-Poisoning with the N-Phenylpyrazole Insecticide Fipronil-a GABAA-Gated Chloride Channel Blocker

Objective: Fipronil, a broad spectrum N-phenylpyrazole insecticide that inhibits GABAA-gated chloride channels, has been in use since the mid-1990s. A high affinity for insect compared to mammalian GABA receptors results in lower animal toxicity than other insecticides blocking this channel. To date...

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