In vitro and in vivo characterization of TC-1827, a novel brain α4β2 nicotinic receptor agonist with pro-cognitive activity

Nicotine activates specific receptors that are cation‐permeable ionic channels located in the central and autonomous nervous systems, as well as at the neuromuscular junction. Administration of nicotine to animals and humans has been shown to enhance cognitive processes. However, side effects linked...

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Veröffentlicht in:	Drug development research 2004-05, Vol.62 (1), p.26-40
Hauptverfasser:	Bohme, Georg Andrees, Letchworth, Sharon R., Piot-Grosjean, Odile, Gatto, Gregory J., Obinu, Marie-Carmen, Caldwell, William S., Laville, Michel, Brunel, Pascale, Pellerin, Rachel, Leconte, Jean-Pierre, Genevois-Borella, Arielle, Dubedat, Pierre, Mazadier, Martine, Pradier, Laurent, Bencherif, Merouane, Benavides, Jesus
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine receptors Alzheimer's disease Biological and medical sciences Cholinergic system ion flux learning and memory long-term potentiation Medical sciences Neuropharmacology neurotransmitter release Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments
Online-Zugang:	Volltext
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