Design, Synthesis, and Biological Evaluation of 1,2,3,7-Tetrahydro-6H-purin-6-one and 3,7-Dihydro-1H-purine-2,6-dione Derivatives as Corticotropin-Releasing Factor1 Receptor Antagonists

A growing body of evidence suggests that CRF1 receptor antagonism offers considerable therapeutic potential in the treatment of diseases resulting from elevated levels of CRF, such as anxiety and depression. A series of novel 1,2,3,7-tetrahydro-6H-purin-6-one and 3,7-dihydro-1H-purine-2,6-dione deri...

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Veröffentlicht in:	Journal of medicinal chemistry 2004-09, Vol.47 (19), p.4741-4754
Hauptverfasser:	Hartz, Richard A, Nanda, Kausik K, Ingalls, Charles L, Ahuja, Vijay T, Molski, Thaddeus F, Zhang, Ge, Wong, Harvey, Peng, Yong, Kelley, Michelle, Lodge, Nicholas J, Zaczek, Robert, Gilligan, Paul J, Trainor, George L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments
Online-Zugang:	Volltext
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