Simvastatin reduces MMP-3 level in interleukin 1β stimulated human chondrocyte culture

Objectives: Matrix metalloproteinases (MMPs) produced by chondrocytes play a role in the development of cartilage degradation in joint diseases. Moreover, inhibition of MMP secretion by macrophages accumulating in arteriosclerotic plaques would account for the plaque stabilising activity of statins...

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Veröffentlicht in:	Annals of the rheumatic diseases 2004-07, Vol.63 (7), p.867-869
Hauptverfasser:	Lazzerini, P E, Capecchi, P L, Nerucci, F, Fioravanti, A, Chellini, F, Piccini, M, Bisogno, S, Marcolongo, R, Laghi Pasini, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences chondrocytes Diseases of the osteoarticular system matrix metalloproteinase Medical sciences MMP MMP-3 proteoglycan simvastatin
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